Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD+ and a designed inhibitor

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7789-7794

  Nango, Eriko ^a   Yamamoto, Takashi ^a   Kumasaka, Takashi ^b   Eguchi, Tadashi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

Author keywords

Hydroxy acid oxidative decarboxylases; Crystal structure; Inhibitor; Isopropylmalate dehydrogenase; Leucine biosynthesis

Indexed keywords

3 ISOPROPYLMALATE DEHYDROGENASE; 3 ISOPROPYLMALATE DEHYDROGENASE INHIBITOR; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; NONHUMAN; THERMUS THERMOPHILUS;

3-ISOPROPYLMALATE DEHYDROGENASE; AMINO ACID SEQUENCE; BINDING SITES; CARBOXY-LYASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; LEUCINE; MOLECULAR SEQUENCE DATA; NAD; PROTEIN CONFORMATION; THERMUS THERMOPHILUS;

THERMUS THERMOPHILUS; THIA;

EID: 71749105508     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.025     Document Type: Article

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