Synthesis of cyclopropane substrate analog for 3-isopropylmalate dehydrogenase and its mechanism-based inhibition

Tetrahedron

Volumn 55, Issue 10, 1999, Pages 2927-2936

  Chiba, Akira ^a   Eguchi, Tadashi ^a   Oshima, Tairo ^b   Kakinuma, Katsumi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Cyclopropanes; Enzyme inhibitors; Enzymes and enzyme reactions; Hydroxy acids and derivatives

Indexed keywords

3 ISOPROPYLMALATE DEHYDROGENASE; CYCLOPROPANE DERIVATIVE; ENZYME INHIBITOR; ESSENTIAL AMINO ACID; LEUCINE; MALIC ACID DERIVATIVE;

ARTICLE; COMPETITIVE INHIBITION; DECARBOXYLATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; OXIDATION; PRIORITY JOURNAL; SYNTHESIS;

EID: 0033525453     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(99)00074-5     Document Type: Article

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