Synthetic and mechanistic studies of (2R,3S)-3-vinylmalic acid as a mechanism-based inhibitor of 3-isopropylmalate dehydrogenase

Journal of Organic Chemistry

Volumn 64, Issue 17, 1999, Pages 6159-6165

  Chiba, Akira ^a   Aoyama, Tetsuya ^a   Suzuki, Rieko ^a   Eguchi, Tadashi ^a   Oshima, Tairo ^b   Kakinuma, Katsumi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLMALATE DEHYDROGENASE; 3 VINYLMALIC ACID; ENZYME INHIBITOR; LEUCINE; MALIC ACID; PENTANE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARTICLE; COVALENT BOND; ENZYME INHIBITION; ENZYME MECHANISM; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SYNTHESIS;

EID: 0033588346     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo982206c     Document Type: Article

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