Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6181-6184

  Hu, Jiaxin ^a   Dodd, David W ^b   Hudson, Robert H E ^b   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Antisense; Huntingtin; Peptide nucleic acid; PNA

Indexed keywords

[BIS O (AMINOETHOXY)PHENYL]PYRROLOCYTOSINE; GUANINE; HUNTINGTIN; NUCLEIC ACID BASE; OLIGOMER; PEPTIDE NUCLEIC ACID; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROGEN BOND; INTRACELLULAR SPACE; MELTING POINT; PROTEIN EXPRESSION; TEMPERATURE;

ALLELES; CELL LINE; CYTOSINE; FLUORESCENT DYES; HUMANS; HYDROGEN BONDING; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDE NUCLEIC ACIDS; PYRROLES; RNA, MESSENGER; TRANSITION TEMPERATURE;

EID: 71749087536     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.004     Document Type: Article

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