Automation of the SomaLogic Proteomics Assay: A Platform for Biomarker Discovery

Journal of Laboratory Automation

Volumn 14, Issue 6, 2009, Pages 360-366

  Keeney, Tracy R ^a   Bock, Christopher ^a   Gold, Larry ^a,b   Kraemer, Stephan ^a   Lollo, Bridget ^a   Nikrad, Malti ^a   Stanton, Martin ^a   Stewart, Alex ^a   Vaught, Jonathan D ^a   Walker, Jeffrey J ^a  

^a SomaLogic Inc   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

aptamer; automation; in vitro diagnostics; proetomics

Indexed keywords

APTAMER; APTAMERS; AUTOMATED METHODS; AUTOMATION SYSTEMS; BIO-MARKER DISCOVERY; CLINICAL STUDY; HUMAN DISEASE; IN-VITRO DIAGNOSTIC; MANUAL METHODS; NEW TOOLS; PROTEOMICS; PROTEOMICS TECHNOLOGY;

BIOMARKERS; MOLECULAR BIOLOGY; PROTEINS; SPECIFICATIONS;

AUTOMATION;

BIOLOGICAL MARKER;

ARTICLE; AUTOANALYSIS; BIOASSAY; CLINICAL EFFECTIVENESS; COMBINATORIAL CHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HYBRIDIZATION; LABORATORY AUTOMATION; PROCESS TECHNOLOGY; PROTEIN DETERMINATION; PROTEOMIC ASSAY; PROTEOMICS; VALIDATION PROCESS;

EID: 71649093729     PISSN: 22110682     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2009.05.003     Document Type: Article

References (13)

1. Brody E. N. Willis M. C. Smith J. D. Jayasena S. Zichi D. Gold L. The use of aptamers in large arrays for molecular diagnostics. Mol. Diagn. 1999, 4, 381–388.
2. Gold L. Oligonucleotides as research, diagnostic, and therapeutic agents. J. Biol. Chem. 1995, 270, 13581–13584.
3. Hartwell L. Mankoff D. Paulovich A. Ramsey S. Swisher E. Cancer biomarkers: A systems approach. Nat. Biotechnol. 2006, 24(8), 905–908.
4. Zichi D. Eaton B. Singer B. Gold L. Proteomics and diagnostics: Let's get specific, again. Curr. Opin. Chem. Biol. 2008, 12, 78–85.
5. Zichi D. Method for generating aptamers with improved off-rates, US2009/0004667, Jan 1, 2009.
6. Schneider D. J. Multiplexed analyses of test samples, US2009/0042206, Feb 12, 2009.
7. Tuerk C. Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990, 249, 505–510.
8. Ellington A. D. Szostak J. W. In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346, 818–822.
9. Service R. F. Proteomics ponders prime time. Science 2008, 321, 1758–1761.
10. Omenn G. S. Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 2005, 5, 3226–3245.
11. Lin H. Lee E. Hestir K. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 2008, 320, 807–811.
12. Wu G. Doberstein S. K. HTS technologies in biopharmaceutical discovery. Drug Discov. Today 2006, 11, 718–724.
13. Muthusamy B. Plasma proteome database as a resource for proteomics research. Proteomics 2005, 5, 3531–3536.