The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: Case-control studies and an updated meta-analysis

Schizophrenia Research

Volumn 116, Issue 1, 2010, Pages 61-67

  Nunokawa, Ayako ^a   Watanabe, Yuichiro ^a,b   Kaneko, Naoshi ^a   Sugai, Takuro ^a   Yazaki, Saori ^c   Arinami, Tadao ^c   Ujike, Hiroshi ^d   Inada, Toshiya ^e   Iwata, Nakao ^f   Kunugi, Hiroshi ^g   Sasaki, Tsukasa ^h   Itokawa, Masanari ⁱ   Ozaki, Norio ^j   Hashimoto, Ryota ^k   Someya, Toshiyuki ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e SEIWA HOSPITAL   (Japan)

^f FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^h UNIVERSITY OF TOKYO   (Japan)

ⁱ TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^j NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^k OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

DRD3; Resequencing; Schizophrenia; Tagging SNP

Indexed keywords

DOPAMINE 3 RECEPTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SAMPLE SIZE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPLOTYPES; HUMANS; JAPAN; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D3; SCHIZOPHRENIA;

EID: 71549168918     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2009.10.016     Document Type: Article

References (37)

1. Allen N.C., Bagade S., McQueen M.B., Ioannidis J.P.A., Kavvoura F.K., Khoury M.J., Tanzi R.E., and Bertram L. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat. Genet. 40 7 (2008) 827-834
2. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 2 (2005) 263-265
3. Bombin I., Arango C., Mayoral M., Castro-Fornieles J., Gonzalez-Pinto A., Gonzalez-Gomez C., Moreno D., Parellada M., Baeza I., Graell M., Otero S., Saiz P.A., and Patiño-Garcia A. DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B 6 (2008) 873-879
4. Brzustowicz L.M., Hodgkinson K.A., Chow E.W.C., Honer W.G., and Bassett A.S. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288 5466 (2000) 678-682
5. Costas J., Carrera N., Domínguez E., Vilella E., Martorell L., Valero J., Gutiérrez-Zotes A., Labad A., and Carracedo A. A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia. Hum. Genet. 124 6 (2009) 607-613
6. Crocq M.A., Mant R., Asherson P., Williams J., Hode Y., Mayerova A., Collier D., Lannfelt L., Sokoloff P., Schwartz J.C., Gill M., Macher J.P., McGuffin P., and Owen M.J. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J. Med. Genet. 29 12 (1992) 858-860
7. de Bakker P.I., Yelensky R., Pe'er I., Gabriel S.B., Daly M.J., and Altshuler D. Efficiency and power in genetic association studies. Nat. Genet. 37 11 (2005) 1217-1223
8. Domínguez E., Loza M.I., Padín F., Gesteira A., Paz E., Páramo M., Brenlla J., Pumar E., Iglesias F., Cibeira A., Castro M., Caruncho H., Carracedo A., and Costas J. Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population. Schizophr. Res. 90 1-3 (2007) 123-129
9. Egger M., Smith D.G., Schneider M., and Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 315 7109 (1997) 629-634
10. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., Higgins J., DeFelice M., Lochner A., Faggart M., Liu-Cordero S.N., Rotimi C., Adeyemo A., Cooper R., Ward R., Lander E.S., Daly M.J., and Altshuler D. The structure of haplotype blocks in the human genome. Science 296 5576 (2002) 2225-2229
11. 3 receptors and use of antipsychotics in patients with schizophrenia. A postmortem study. Arch. Gen. Psychiatry 54 3 (1997) 225-232
12. 3 dopamine receptor mRNA in blood lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 98 2 (2001) 625-628
13. Ishiguro H., Okuyama Y., Toru M., and Arinami T. Mutation and association analysis of the 5′ region of the dopamine D3 receptor gene in schizophrenia patients: identification of the Ala38Thr polymorphism and suggested association between DRD3 haplotypes and schizophrenia. Mol. Psychiatry 5 4 (2000) 433-438
14. Kaneko N., Muratake T., Kuwabara H., Kurosaki T., Takei M., Ohtsuki T., Arinami T., Tsuji S., and Someya T. Autosomal linkage analysis of a Japanese single multiplex schizophrenia pedigree reveals two candidate loci on chromosomes 4q and 3q. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B 6 (2007) 735-742
15. Kennedy J.L., Billett E.A., Macciardi F.M., Verga M., Parsons T.J., Meltzer H.Y., Lieberman J., and Buchanan J.A. Association study of dopamine D3 receptor gene and schizophrenia. Am. J. Med. Genet. 60 6 (1995) 558-562
16. Li Y., and Abecasis G.R. Mach 1.0: rapid haplotype reconstruction and missing genotype inference. Am. J. Hum. Genet. S79 (2006) 2290
17. 3 receptor with the Semliki Forest virus system. Biochem. Biophys. Res. Commun. 225 3 (1996) 1068-1072
18. Ma G., He Z., Fang W., Tang W., Huang K., Li Z., He G., Xu Y., Feng G., Zheng T., Zhou J., He L., and Shi Y. The Ser9Gly polymorphism of the dopamine D3 receptor gene and risk of schizophrenia: an association study and a large meta-analysis. Schizophr. Res. 101 1-3 (2008) 26-35
19. Meador-Woodruff J.H., Haroutunian V., Powchik P., Davidson M., Davis K.L., and Watson S.J. Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia. Arch. Gen. Psychiatry 54 12 (1997) 1089-1095
20. Mulert C., Juckel G., Giegling I., Pogarell O., Leicht G., Karch S., Mavrogiorgou P., Möller H.J., Hegerl U., and Rujescu D. A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials. Neuropsychopharmacology 31 6 (2006) 1335-1344
21. Nunokawa A., Watanabe Y., Muratake T., Kaneko N., Koizumi M., and Someya T. No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population. Neurosci. Res. 58 3 (2007) 291-296
22. Purcell S., Cherny S.S., and Sham P.C. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19 1 (2003) 149-150
23. 3 receptor Ser9Gly polymorphism modulates prepulse inhibition of the acoustic startle reflex. Biol. Psychiatry 64 3 (2008) 235-240
24. Rybakowski J.K., Borkowska A., Czerski P.M., and Hauser J. Dopamine D3 receptor (DRD3) gene polymorphism is associated with the intensity of eye movement disturbances in schizophrenic patients and healthy subjects. Mol. Psychiatry 6 6 (2001) 718-724
25. Rybakowski J.K., Borkowska A., Czerski P.M., Kapelski P., Dmitrzak-Weglarz M., and Hauser J. An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia. J. Neural Transm. 112 11 (2005) 1575-1582
26. 3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia. Proc. Natl. Acad. Sci .U. S. A. 90 19 (1993) 8942-8946
27. 3 receptor in schizophrenia and in antipsychotic drug actions. Brain Res. Brain Res. Rev. 31 2-3 (2000) 277-287
28. Shaikh S., Collier D.A., Sham P.C., Ball D., Aitchison K., Vallada H., Smith I., Gill M., and Kerwin R.W. Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia. Hum. Genet. 97 6 (1996) 714-719
29. 3) as a target for neuroleptics. Nature 347 6289 (1990) 146-151
30. Szekeres G., Kéri S., Juhász A., Rimanóczy Á., Szendi I., Czimmer C., and Janka Z. Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 124B 1 (2004) 1-5
31. Talkowski M.E., Mansour H., Chowdari K.V., Wood J., Butler A., Varma P.G., Prasad S., Semwal P., Bhatia T., Deshpande S., Devlin B., Thelma B.K., and Nimgaonkar V.L. Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples. Biol. Psychiatry 60 6 (2006) 570-577
32. Tanaka T., Igarashi S., Onodera O., Tanaka H., Takahashi M., Maeda M., Kameda K., Tsuji S., and Ihda S. Association study between schizophrenia and dopamine D3 receptor gene polymorphism. Am. J. Med. Genet. 67 4 (1996) 366-368
33. Tsai S.J., Yu Y.W., Chen T.J., Chen M.C., and Hong C.J. Association analysis for dopamine D3 receptor, dopamine D4 receptor and dopamine transporter genetic polymorphisms and P300 event-related potentials for normal young females. Psychiatr. Genet. 13 1 (2003) 51-53
34. Utsunomiya K., Shinkai T., De Luca V., Hwang R., Sakata S., Fukunaka Y., Chen H.I., Ohmori O., and Nakamura J. Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: evidence from a case-control study and meta-analysis. Neurosci. Lett. 444 2 (2008) 161-165
35. 3 receptor mRNA in schizophrenic and bipolar patients. Neuropsychobiology 50 4 (2004) 305-310
36. Watanabe Y., Muratake T., Kaneko N., Nunokawa A., and Someya T. No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population. Schizophr. Res. 84 1 (2006) 29-35
37. Watanabe Y., Nunokawa A., Kaneko N., and Someya T. Meta-analysis of case-control association studies between the C270T polymorphism of the brain-derived neurotrophic factor gene and schizophrenia. Schizophr. Res. 95 1-3 (2007) 250-252