Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 683, Issue 1-2, 2010, Pages 29-34

  Suzuki, Keiji ^a   Kodama, Seiji ^c   Watanabe, Masami ^b  

^a NAGASAKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Osaka Prefecture University   (Japan)

Author keywords

CHO; Chromosome aberration; DNA repair; Genomic instability; Ionizing radiation; Non homologous end joining

Indexed keywords

DOUBLE STRANDED DNA; GENE PRODUCT; KU80 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DAUGHTER CELL; DICENTRIC CHROMOSOME; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE INDUCTION; GENOMIC INSTABILITY; IONIZING RADIATION; MAMMAL CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ANIMALS; ANTIGENS, NUCLEAR; CELL CYCLE PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CHO CELLS; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CRICETINAE; CRICETULUS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; FIBROBLASTS; GENOMIC INSTABILITY; HUMANS; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; MICE, SCID; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; TUMOR SUPPRESSOR PROTEINS;

CRICETULUS GRISEUS; MAMMALIA;

EID: 71549154987     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.10.003     Document Type: Article

References (51)

1. Friedberg E.C. DNA damage and repair. Nature 421 (2003) 436-440
2. Weinstock D.M., Richardson C.A., Elliott B., and Jasin M. Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. DNA Repair 5 (2006) 1065-1074
3. Wynman C., and Kannar R. DNA double strand break repair: all's well that ends well. Annu. Rev. Genet. 40 (2006) 363-383
4. Jeggo P.A., and Lobrich M. DNA double-strand breaks: their cellular and clinical impact?. Oncogene 26 (2007) 7717-7719
5. Mahaney B.L., Meek K., and Lees-Miller S.P. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem. J. 417 (2009) 639-650
6. Pastink A., Eeken J.C., and Lohman P.H. Genomic integrity and the repair of double-strand breaks. Mutat. Res. 480/481 (2001) 37-50
7. van Gent D.C., Hoeijmakers J.H., and Kannar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2 (2001) 196-206
8. Burma S., Chen B.P., and Chen D.J. Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair 5 (2006) 1042-1048
9. Sonoda E., Hochegger H., Saberi A., Taniguchi Y., and Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair 5 (2006) 1021-2129
10. Leonhardt E.A., Trinh M., Chu K., and Dewey W.C. Evidence that most radiation-induced HPRT mutants are generated directly by the initial radiation exposure. Mutat. Res. 426 (1999) 23-30
11. Morgan W.F., Day J.P., Kaplan M.I., McGhee E.M., and Limoli C.L. Genomic instability induced by ionizing radiation. Radiat. Res. 146 (1996) 247-258
12. Little J.B. Genomic instability and bystander effects: a historical perspective. Oncogene 22 (2003) 6978-6987
13. Lorimore S.A., Coates P.J., and Wright E.G. Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation. Oncogene 22 (2003) 7058-7069
14. Suzuki K., Ojima M., Kodama S., and Watanabe M. Radiation-induced DNA damage and delayed induced genomic instability. Oncogene 22 (2003) 6988-6993
15. Kadhim M.A., MacDonald D.A., Goodhead D.T., Lorimore S.A., Marsden S.J., and Wright E.G. Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature 355 (1992) 738-740
16. Suzuki K. Multistep nature of X-ray-induced neoplastic transformation in mammalian cells: genetic alteration and instability. J. Radiat. Res. 38 (1997) 55-63
17. Huang L., Snyder A.R., and Morgan W.F. Radiation-induced genomic instability and its implications for radiation carcinogenesis. Oncogene 22 (2003) 5848-5854
18. Niwa O. Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies. Oncogene 22 (2003) 7078-7086
19. Azzam E.I., de Toledo S.M., and Little J.B. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 22 (2003) 7050-7057
20. Limoli C.L., Giedzinski E., Morgan W.F., Swarts S.G., Jones G.D., and Hyun W. Persistent oxidative stress in chromosomally unstable clones. Cancer Res. 63 (2003) 3107-3111
21. Kim G.J., Fiskum G.M., and Morgan W.F. A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability. Cancer Res. 66 (2006) 10377-10383
22. Wright E.G. Microenvironment and genetic factors in haemopoietic radiation responses. Int. J. Radiat. Biol. 83 (2007) 813-818
23. Coates P.J., Rundle J.K., Lorimore S.A., and Wright E.G. Indirect macrophage responses to ionizing radiation: implications for genotype-dependent bystander signaling. Cancer Res. 68 (2008) 450-456
24. Miller J.H., Jin S., Morgan W.F., Yang A., Wan Y., Aypar U., Peters J.S., and Springer D.L. Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometry. Radiat. Res. 169 (2008) 700-706
25. Suzuki K., Yokoyama S., Waseda S., Kodama S., and Watanabe M. Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation. Cancer Res. 63 (2003) 936-941
26. Toyokuni H., Maruo A., Suzuki K., and Watanabe M. The contribution of radiation-induced large deletion of the genome to chromosomal instability. Radiat. Res. 171 (2009) 198-203
27. Chang W.P., and Little J.B. Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells. Radiat. Res. 131 (1992) 53-59
28. Urushibara A., Kodama S., Suzuki K., Desa M.B.Md., Suzuki F., Tsutsui T., and Watanabe M. Involvement of telomere dysfunction in the induction of genomic instability by radiation in scid mouse cells. Biochem. Biophys. Res. Commun. 313 (2004) 1037-1043
29. Undarmaa B., Kodama S., Suzuki K., Niwa O., and Watanabe M. X-ray-induced telomeric instability in Atm-deficient mouse cells. Biochem. Biophys. Res. Commun. 315 (2004) 51-58
30. Barber R.C., Hickenbotham P., Hatch T., Kelly D., Topchiy N., Almeida G.M., Jones G.D., Johnson G.E., Parry J.M., Rothkamm K., and Dubrova Y.E. Radiation-induced transgenerational alterations in genome stability and DNA damage. Oncogene 25 (2006) 7336-7342
31. Huang L., Kim P.M., Nickoloff J.A., and Morgan W.F. Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells. Cancer Res. 67 (2007) 1099-1104
32. Rouse J., and Jackson S.P. Interfaces between the detection, signaling, and repair of DNA damage. Science 297 (2002) 547-551
33. Kastan M.B., and Bartek J. Cell-cycle checkpoints and cancer. Nature 432 (2004) 316-323
34. Lukas J., Lukas C., and Bartek J. Mammalian cell cycle checkpoint-signalling pathways and their organization in space and time. DNA Repair 3 (2004) 997-1007
35. Downs J.A., Nussenzweig M.C., and Nussenzweig A. Chromatin dynamics and the preservation of genetic information. Nature 447 (2007) 951-958
36. Harper J.W., and Elledge S.J. The DNA damage response: ten years after. Mol. Cell 28 (2007) 739-745
37. Lavin M.F., and Kozlov S. ATM activation and DNA damage response. Cell Cycle 6 (2007) 931-942
38. Nakashima M., Suzuki K., Meirmanov S., Naruke Y., Matsuu-Matsuyama M., Shichijo K., Saenko V., Kondo H., Hayashi T., Ito M., Yamashita S., and Sekine I. Foci formation of p53-binding protein 1 in thyroid tumors: activation of genomic instability during thyroid carcinogenesis. Int. J. Cancer 122 (2008) 1082-1088
39. Singleton B.K., Priestley A., Steingrimsdottir H., Gell D., Blunt T., Jackson S.P., Lehmann A.R., and Jeggo P.A. Molecular and biochemical characterization of xrs mutants defective in Ku80. Mol. Cell. Biol. 17 (1997) 1264-1273
40. Kemp L.M., and Jeggo P.A. Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line. Mutat. Res. 166 (1986) 255-263
41. Darroudi F., and Natarajan A.T. Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6. I. Induction of chromosomal aberrations by X-irradiation and its modulation with 3-aminobenzamide and caffein. Mutat. Res. 177 (1987) 133-148
42. Iliakis G., Wang H., Perrault A.R., Boecker W., Rosidi B., Windhofer F., Wu W., Guan J., Terzoudi G., and Pantelias G. Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet. Genome Res. 104 (2004) 14-20
43. Liang F., Romanienko P.J., Weaver D.T., Jeggo P.A., and Jasin M. Chromosomal double-strand break repair in ku80-deficient cells. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 8929-8933
44. Natarajan A.T., and Palitti F. DNA repair and chromosomal alterations. Mutat. Res. 657 (2008) 3-7
45. Gao Y., Chaudhuri J., Zhu C., Davidson L., Weaver D.T., and Alt F.W. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9 (1998) 367-376
46. Hu T., Miller C.M., Ridder G.M., and Aardema M.J. Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications foe genotoxicity testing. Mutat. Res. 426 (1999) 51-62
47. Tzang B.S., Lai Y.C., Hsu M., Chang H.W., Chang C.C., Huang P.C., and Liu Y.C. Function and sequence analysis of tumor suppressor gene p53 of CHO.K1 cells. DNA Cell Biol. 18 (1999) 315-321
48. Hande M.P., Lansdorp P.M., and Natarajan A.T. Induction of telomerase activity by in vivo X-irradiation of mouse splenocytes and its possible role in chromosome healing. Mutat. Res. 404 (1998) 205-214
49. Slijepcevic P., and Bryant P.E. Chromosome healing, telomere capture, and mechanisms of radiation-induced chromosome breakage. Int. J. Radiat. Biol. 73 (1998) 1-13
50. Chang W.P., and Little J.B. Persistent elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotypes. Mutat. Res. 270 (1992) 191-199
51. Lim D.S., Vogel H., Willefrod D.M., Sands A.T., Platt K.A., and Hasty P. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol. Cell. Biol. 20 (2000) 3772-3780