Structure-activity analysis of the growth hormone secretagogue GHRP-6 by α- And β-Amino γ-lactam positional scanning

Chemical Biology and Drug Design

Volumn 75, Issue 1, 2010, Pages 40-50

  Boutard, Nicolas ^a   Jamieson, Andrew G ^a,b   Ong, Huy ^a   Lubell, William D ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CD36; Conformational constraint; Cyclic sulfamidate; Freidinger Veber lactam; GHRP 6; GHS R1a; Lactam; Lactam scanning; Peptide; Peptidomimetic; Solid phase synthesis

Indexed keywords

ALANINE; CD36 ANTIGEN; DEXTRO PHENYLALANINE; GAMMA LACTAM DERIVATIVE; GHRELIN RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE;

ALKYLATION; ANNULATION REACTION; ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG SELECTIVITY; IC 50; MICROWAVE RADIATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTIGENS, CD36; BETA-LACTAMS; GROWTH HORMONE; HUMAN GROWTH HORMONE; LACTAMS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN FOLDING; RECEPTORS, GHRELIN;

EID: 71449093017     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00913.x     Document Type: Article

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