The role of G-proteins in the dimerisation of human somatostatin receptor types 2 and 5

Regulatory Peptides

Volumn 159, Issue 1-3, 2010, Pages 3-8

  Grant, Michael ^a   Kumar, Ujendra ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Dimerisation; Dissociation; Fluorescence resonance energy transfer; G protein coupled receptors; Heterodimerisation; Pertussis toxin; Somatostatin; Somatostatin receptors

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 5;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; PERTUSSIS TOXIN; PROTEIN MULTIMERIZATION; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN;

EID: 71349085133     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2009.08.011     Document Type: Article

References (37)

1. Moller L.N., Stidsen C.E., Hartmann B., and Holst J.J. Somatostatin receptors. Biochim Biophys Acta 1616 (2003) 1-84
2. Weckbecker G., Lewis I., Albert R., Schmid H.A., Hoyer D., and Bruns C. Opportunities in somatostatin research: biological, chemical and therapeutic aspects. Nat Rev Drug Discov 2 (2003) 999-1017
3. Grant M., Alturaihi H., Jaquet P., Collier B., and Kumar U. Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. Mol Endocrinol 22 (2008) 2278-2292
4. Baragli A., Alturaihi H., Watt H.L., Abdallah A., and Kumar U. Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 co-immunoprecipitation and fluorescence resonance energy transfer analysis. Cell Signal 19 (2007) 2304-2316
5. Duran-Prado M., Bucharles C., Gonzalez B.J., Vazquez-Martinez R., Martinez-Fuentes A.J., Garcia-Navarro S., Rhodes S.J., Vaudry H., Malagon M.M., and Castano J.P. Porcine somatostatin receptor 2 displays typical pharmacological sst2 features but unique dynamics of homodimerization and internalization. Endocrinology 148 (2007) 411-421
6. Grant M., Collier B., and Kumar U. Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking. J Biol Chem 279 (2004) 36179-36183
7. Grant M., Patel R.C., and Kumar U. The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors. J Biol Chem 279 (2004) 38636-38643
8. Patel R.C., Kumar U., Lamb D.C., Eid J.S., Rocheville M., Grant M., Rani A., Hazlett T., Patel S.C., Gratton E., and Patel Y.C. Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells. Proc Natl Acad Sci U S A 99 (2002) 3294-3299
9. Rocheville M., Lange D.C., Kumar U., Patel S.C., Patel R.C., and Patel Y.C. Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288 (2000) 154-157
10. Rocheville M., Lange D.C., Kumar U., Sasi R., Patel R.C., and Patel Y.C. Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J Biol Chem 275 (2000) 7862-7869
11. Pfeiffer M., Koch T., Schroder H., Klutzny M., Kirscht S., Kreienkamp H.J., Hollt V., and Schulz S. Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A). J Biol Chem 276 (2001) 14027-14036
12. Pfeiffer M., Koch T., Schroder H., Laugsch M., Hollt V., and Schulz S. Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization. J Biol Chem 277 (2002) 19762-19772
13. Sharif N., Gendron L., Wowchuk J., Sarret P., Mazella J., Beaudet A., and Stroh T. Coexpression of somatostatin receptor subtype 5 affects internalization and trafficking of somatostatin receptor subtype 2. Endocrinology 148 (2007) 2095-2105
14. Ben-Shlomo A., Wawrowsky K.A., Proekt I., Wolkenfeld N.M., Ren S.G., Taylor J., Culler M.D., and Melmed S. Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. J Biol Chem 280 (2005) 24011-24021
15. Parker S.L., Parker M.S., Sah R., Balasubramaniam A., and Sallee F.R. Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells. Eur J Pharmacol 579 (2008) 13-25
16. Parker S.L., Parker M.S., Sallee F.R., and Balasubramaniam A. Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis toxin-sensitive G-proteins. Regul Pept 144 (2007) 72-81
17. Law P.Y., Erickson-Herbrandson L.J., Zha Q.Q., Solberg J., Chu J., Sarre A., and Loh H.H. Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. J Biol Chem 280 (2005) 11152-11164
18. Fan T., Varghese G., Nguyen T., Tse R., O'Dowd B.F., and George S.R. A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers. J Biol Chem 280 (2005) 38478-38488
19. Dupre D.J., Robitaille M., Rebois R.V., and Hebert T.E. The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annu Rev Pharmacol Toxicol 49 (2009) 31-56
20. Jaquet P., Saveanu A., Gunz G., Fina F., Zamora A.J., Grino M., Culler M.D., Moreau J.P., Enjalbert A., and Ouafik L.H. Human somatostatin receptor subtypes in acromegaly: distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes. J Clin Endocrinol Metab 85 (2000) 781-792
21. Park C., Yang I., Woo J., Kim S., Kim J., Kim Y., Sohn S., Kim E., Lee M., Park H., Jung J., and Park S. Somatostatin (SRIF) receptor subtype 2 and 5 gene expression in growth hormone-secreting pituitary adenomas: the relationship with endogenous srif activity and response to octreotide. Endocr J 51 (2004) 227-236
22. Rohrer S.P., Birzin E.T., Mosley R.T., Berk S.C., Hutchins S.M., Shen D.M., Xiong Y., Hayes E.C., Parmar R.M., Foor F., Mitra S.W., Degrado S.J., Shu M., Klopp J.M., Cai S.J., Blake A., Chan W.W., Pasternak A., Yang L., Patchett A.A., et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 (1998) 737-740
23. Kaslow H.R., Lim L.K., Moss J., and Lesikar D.D. Structure-activity analysis of the activation of pertussis toxin. Biochemistry 26 (1987) 123-127
24. Gurevich V.V., and Gurevich E.V. How and why do GPCRs dimerize?. Trends Pharmacol Sci 29 (2008) 234-240
25. Milligan G. A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization. Br J Pharmacol 153 Suppl 1 (2008) S216-S229
26. Dalrymple M.B., Pfleger K.D., and Eidne K.A. G protein-coupled receptor dimers: functional consequences, disease states and drug targets. Pharmacol Ther 118 (2008) 359-371
27. Hebert T.E., Moffett S., Morello J.P., Loisel T.P., Bichet D.G., Barret C., and Bouvier M. A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J Biol Chem 271 (1996) 16384-16392
28. Lemmon M.A., Treutlein H.R., Adams P.D., Brunger A.T., and Engelman D.M. A dimerization motif for transmembrane alpha-helices. Nat Struct Biol 1 (1994) 157-163
29. Overton M.C., Chinault S.L., and Blumer K.J. Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor. J Biol Chem 278 (2003) 49369-49377
30. Brauner-Osborne H., Wellendorph P., and Jensen A.A. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr Drug Targets 8 (2007) 169-184
31. Cvejic S., and Devi L.A. Dimerization of the delta opioid receptor: implication for a role in receptor internalization. J Biol Chem 272 (1997) 26959-26964
32. Dupre D.J., Robitaille M., Ethier N., Villeneuve L.R., Mamarbachi A.M., and Hebert T.E. Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking. J Biol Chem 281 (2006) 34561-34573
33. Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 308 (2005) 512-517
34. Tulipano G., Stumm R., Pfeiffer M., Kreienkamp H.J., Hollt V., and Schulz S. Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes. J Biol Chem 279 (2004) 21374-21382
35. Gripentrog J.M., Kantele K.P., Jesaitis A.J., and Miettinen H.M. Experimental evidence for lack of homodimerization of the G protein-coupled human N-formyl peptide receptor. J Immunol 171 (2003) 3187-3193
36. Meyer B.H., Segura J.M., Martinez K.L., Hovius R., George N., Johnsson K., and Vogel H. FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. Proc Natl Acad Sci U S A 103 (2006) 2138-2143
37. Decaillot F.M., Rozenfeld R., Gupta A., and Devi L.A. Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci U S A 105 (2008) 16045-16050