α 1A/B-Knockout mice explain the native α 1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other α 1-subtypes

British Journal of Pharmacology

Volumn 158, Issue 7, 2009, Pages 1663-1675

  Methven, L ^a   Simpson, P C ^b,c   McGrath, J C ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1A B adrenoceptor knockout; Adrenoceptor; Confocal microscopy; Fluorescent ligand binding; Vascular smooth muscle; Wire myography

Indexed keywords

8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; PRAZOSIN; RAUWOLSCINE; ADRENERGIC RECEPTOR ALPHA(1A); ADRENERGIC RECEPTOR ALPHA(1B); ADRENERGIC RECEPTOR ALPHA(1D); ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; LIGAND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CAROTID ARTERY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLUORESCENCE; KNOCKOUT MOUSE; MALE; MESENTERIC ARTERY; MOUSE; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASOCONSTRICTION; WILD TYPE; ANIMAL; DRUG EFFECT; GENETICS; METABOLISM; METHODOLOGY; MOUSE MUTANT; PROTEIN BINDING;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CAROTID ARTERIES; FLUORESCENCE; LIGANDS; MALE; MESENTERIC ARTERIES; MICE; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE; MYOGRAPHY; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 71249157375     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00462.x     Document Type: Article

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