Circulating endothelial cells as biomarkers for angiogenesis in tumor progression

Frontiers in Bioscience - Scholar

Volumn 1 S, Issue 1, 2009, Pages 304-318

  Martin Padura, Ines ^a   Bertolini, Francesco ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

Angiogenesis; Anti angiogenic therapy; Cancer; Circulating endothelial progenitors; Endothelial cells; Review; Tumor

Indexed keywords

TUMOR MARKER;

BONE MARROW CELL; CYTOLOGY; GENOMIC INSTABILITY; HUMAN; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); REVIEW; VASCULAR ENDOTHELIUM;

BONE MARROW CELLS; ENDOTHELIUM, VASCULAR; GENOMIC INSTABILITY; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; TUMOR MARKERS, BIOLOGICAL;

EID: 71249150957     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/e28     Document Type: Article

References (98)

1. Peter Carmeliet: Angiogenesis in life, disease and medicine. Nature 438, 932-936 (2005) (Pubitemid 43093958)
2. Judah Folkman: Angiogenesis an organizing principle for drug discovery? Nat Rev Drug Discov 6, 273-285 (2007)
3. Josef Hladovec, Pavel Rossamn: Circulating endothelial cells isolated together with platelets and the experimental modification of their counts in rats. Thromb Res 3, 665-674 (1973)
4. Francesco Bertolini, Yuval Shaked, Patrizia Mancuso, Robert S. Kerbel: The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat Rev Cancer 6, 835-845 (2006) (Pubitemid 44629895)
5. Patrick K Y Goon, Christopher J Boos, Gregory Y H Lip: Circulating endothelial cells markers for vascular dysfunction. Clin Lab 51, 531-538 (2005) (Pubitemid 41644193)
6. Denis A. Smirnov, Bradley W. Foulk, Gerald V. Doyle, Mark C. Connelly, Leon W. M. M. Terstappen, S. Mark O'Hara: Global gene expression profiling of circulating endothelial cells in patients with metastatic carcinomas. Cancer Res 66, 2918-2922 (2006)
7. Ziad Mallat, Hakim Benamer, Bénédicte Hugel, Joëlle Benessiano, P. Gabriel Steg, Jean-Marie Freyssinet, Alain Tedgui: Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 101, 841-843 (2000) (Pubitemid 30117876)
8. Qun Shi, Shahin Rafii, Moses Hong-De Wu, Errol S. Wijelath, Cong Yu, Atsushi Ishida, Yuji Fujita, Sudesh Kothari, Robert Mohle, Lester R. Sauvage, Malcom A. S. Moore, Rainer F. Storb, and William P. Hammond: Evidence for circulating bone marrow-derived endothelial cells. Blood 92, 362-367 (1998) (Pubitemid 28323695)
9. Andrew D. Blann, Alexander Woywodt, Francesco Bertolini, Todd M. Bull, Jill P. Buyon, Robert M. Clancy, Marion Haubitz, Robert P. Hebbel, Gregory Y. H. Lip, Patrizia Mancuso, Jose Sampol, Anna Solovey (6), Francoise Dignat: Circulating endothelial cells. Biomarker of vascular disease. Thromb. Haemost. 93, 228-235 (2005) (Pubitemid 40253726)
10. Alexis S. Bailey, Shuguang Jiang, Michael Afentoulis, Christina I. Baumann, David A. Schroeder, Susan B. Olson, Melissa H. Wong, William H. Fleming: Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells. Blood 103, 13-19 (2004) (Pubitemid 38029913)
11. Yi Lin, Daniel J. Weisdorf, Anna Solovey, Robert P. Hebbel: Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 105, 71-77 (2000) (Pubitemid 30036389)
12. Daniel N Prater, Jamie Case, David A Ingram, Mervir C Yoder: Working hypothesis to redefine endothelial progenitor cells. Leukemia 21, 1141-1149 (2007) (Pubitemid 46831802)
13. Françoise Dignat-George, José Sampol: Circulating endothelial cells in vascular disorders: new insights into an old concept. Eur J Haematol 65, 215-220 (2000)
14. Woywodt A, Blann AD, Kirsch T, Erdbruegger U, Banzet N, Haubitz M, Dignat-George F.: Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J. Thromb. Haemost. 4, 671-677 (2006)
15. A. Widemann, Florence Sabatier, Lyonel Arnaud, Laurent Bonello, Ghassan Al-Massarani, Frank Paganelli, P. Poncelet, Françoise Dignat-George: CD146-based immunomagnetic enrichment followed by multiparameter flow cytometry: a new approach to counting circulating endothelial cells. Journal of Thrombosis and Haemostasis 6, 869-876 (2008) (Pubitemid 351524550)
16. Donald Wlodkowic, Joanna Skommer, Jukka Pelkonen: Towards an understanding of apoptosis detection by SYTO dyes. Cytometry 71, 61-72 (2007) (Pubitemid 46238934)
17. Mario Peichev, Afzal J. Naiyer, Daniel Pereira, Zhenping Zhu, William J. Lane, Mathew Williams, Mehmet C. Oz, Daniel J. Hicklin, Larry Witte, Malcolm A. S. Moore, Shahin Rafii: Expression of VEGFR-2 and AC133 by circulating human CD34 (+) cells identifies a population of functional endothelial precursors. Blood 95, 952-958 (2000) (Pubitemid 30062717)
18. Yuval Shaked, Francesco Bertolini, Shan Man, Michael S. Rogers, Dave Cervi, Thomas Foutz, Kimberley Rawn, Daniel Voskas, Daniel J. Dumont, Yaacov Ben-David1, Jack Lawler, Jack Henkin, Jim Huber, Daniel J. Hicklin, Robert J. D'Amato Robert S. Kerbel: Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell 7, 101-111 (2005) (Pubitemid 40126386)
19. Manuela Capillo, Patrizia Mancuso, Alberto Gobbi, Silvia Monestiroli, Giancarlo Pruneri, Chiara Dell'Agnola, Giovanni Martinelli, Leonard Shultz, Francesco Bertolini: Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors. Clin Cancer Res 9, 377-382 (2003) (Pubitemid 36109755)
20. Paul Beaudry, Yasuhiro Hidaa, Taturo Udagawaa, Ian P. Alwayna, Arin K. Greenea, Danielle Arsenaulta, Judah Folkmana, John V. Heymacha, Sandra Ryeoma, Mark Puder: Endothelial progenitor cells contribute to accelerated liver regeneration. Journal of Pediatric Surgery 42, 1190-1198 (2007) (Pubitemid 47017289)
21. Daniel J Nolan, Alessia Ciarrochi, Albert S Mellik, Jaspreet S Jaggi, Kathryn Bambino, Sunita Gupta, Emily Heikamp, Michael R McDewitt, David A Sheinberg, Robert Benezra, Vivek Mittal: Bone marrow-derived endothelial progenitor cells are a major determinant of nascent neovascularization. Genes Dev 21, 1546-1558 (2007) (Pubitemid 46955726)
22. Chad May, Jacqueline F. Doody, Rashed Abdullah, Paul Balderes, Xiaohong Xu, Chien Peter Chen, Zhenping Zhu, Lawrence Shapiro, Paul Kussie, Daniel J. Hicklin, Fang Liao, Peter Bohlen: Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood 105, 4337-4344 (2005) (Pubitemid 40723657)
23. Mervin C. Yoder, Laura E. Mead, Daniel Prater, Theresa R. Krier, Karim N. Mroueh, Fang Li, Rachel Krasich, Constance J. Temm, Josef T. Prchal, David A. Ingram: Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109, 1801-1809 (2007) (Pubitemid 46348173)
24. Kewal Asosingh, Hendrik De Raeve, Eline Menu, Ivan Van Riet, Eric Van Marck, Benjamin Van Camp, and Karin Vanderkerken: Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity. Blood, 103:3131-3137 (2004) (Pubitemid 38451691)
25. Lynn Hlatky, Philip Hahnfeldt, Judah Folkman: Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J. Natl Cancer Inst 94, 883-893 (2002) (Pubitemid 34778087)
26. Lysa M Coussens, Zena Werb: Inflammation and Cancer. Nature 420, 860-867 (2002) (Pubitemid 36019639)
27. Jeffrey W Pollard: Tumour-educated macrophages promote tumor progression and metastasis. Nat Rev Cancer 4, 71-79 (2004)
28. Hans-Georg Kopp, Carlos A Ramos, Shanin Rafii: Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol 13, 175-181 (2006)
29. Jose R. Conejo-Garcia, Ronald J. Buckanovich, Fabian Venecia, Maria C. Courreges, Stephen C. Rubin, Richard G. Carroll, George Coukos: Vascular leukocytes contribute to tumor vascularization. Blood 105, 679-681 (2005) (Pubitemid 40070752)
30. Michele De Palma, Mary Anna Venneri, Rossella Galli, Lucia Sergi, Letterio S. Politi, Maurilio Sampaolesi, Luigi Naldini: Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8, 211-226 (2005) (Pubitemid 41317592)
31. Mary Anna Venneri, Michele De Palma, Maurilio Ponzoni, Ferdinando Pucci, Cristina Scilezo, Erika Zonari, Roberta Mazzieri, Claudio Doglioni, Luigi Naldini: Identification of proangiogenic TIE-2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 109, 5276-5285 (2007) (Pubitemid 46890548)
32. Michele De Palma, Mary Anna Venneri, Carlo Roca, Luigi Naldini: Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopietic stem cells. Nat Med 9, 789-795 (2003) (Pubitemid 36749231)
33. Myriam Grunewald, Inbal Avraham, Yuval Dor, Esther Bachar-Lustig, Ahuva Itin, Steffen Yung, Stephano Chimenti, Limor Landsman, Rinat Abramovitch, Eli Kesh: VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124, 175-189 (2006) (Pubitemid 43069318)
34. Taturo Udagawa, Mark Puder, Mark Wood, Brian C. Schaefer, Robert J. D'Amato: Analysis of tumor-associated stromal cells using SCID GFP transgenic mice: contribution of local and bone marrow-derived host cells. FASEB J 20, 95-102 (2006) (Pubitemid 43100480)
35. Dontscho Kerjaschki, Nicole Huttary, Ingrid Raab, Heinz Regele, Katalin Bojarski-Nagy, Gregor Bartel, Stefan M Krober, Hidegard Greinix, Agathe Rosenmaier, Franz Karlhofer, Nikolaus Wick, Peter R Mazal: Lymphatic endothelial progenitor cells contribute to de novo lymphoangiogenesis in human renal transplants. Nat Med 12, 230-234 (2006) (Pubitemid 43214751)
36. Patricia M Fernandez, Frederick R Rikles: Tissue factor and angiogenesis in cancer Curr Opin Hematol 9:401-406 (2002) (Pubitemid 34864611)
37. Joel W. Slaton, Paul Perrotte, Keiji Inoue, Colin P. N. Dinney, Isaiah J. Fidler: Interferon-alpha-mediated downregulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res 5, 2726-2734 (1999) (Pubitemid 29493945)
38. Ilhan Celik, Oguzkan Sürücü, Carsten Dietz, John V. Heymach, Jeremy Force, Iris Höschele, Christian M. Becker, Judah Folkman, Oliver Kisker: Therapeutic efficacy of endostatin exhibits a biphasic dose-response curve. Cancer Res 65, 11044-11050 (2005) (Pubitemid 41713375)
39. Michael I. Dorrell, Edith Aguilar, Lea Scheppke, Faith H. Barnett, Martin Friedlander: Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis, Proc. Natl Acad Sci USA 104, 967-72 (2007) (Pubitemid 46154720)
40. Robet S Kerbel: Antiangiogenic therapy: A universal chemosensitization strategy for cancer? Science 312, 1171-1175 (2006) (Pubitemid 43801134)
41. Rakesh K. Jain: Molecular regulation of vessel maturation. Nat Med 9, 685-693 (2003) (Pubitemid 36749217)
42. Tracy T. Batchelor, Gregory Sorensen, Emmanuelle di Tomaso, Wei-Ting Zhang, Dan G. Duda, Kenneth S. Cohen, Kevin R. Kozak, Daniel P. Cahill, Poe-Jou Chen, Mingwang Zhu, Marek Ancukiewicz, Maciej M. Mrugala, Scott Plotkin, Jan Drappatz, David N. Louis, Percy Ivy, David T. Scadden, Thomas Benner, Jay S. Loeffler, Patrick Y. Wen, Rakesh K. Jain: AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11, 83-95 (2007) (Pubitemid 46075199)
43. Christopher Calabrese, Helen Poppleton, Mehmet Kocak, Twala L. Hogg, Christine Fuller, Blair Hamner, Eun Young Oh, M. Waleed Gaber, David Finklestein, Meredith Allen, Adrian Frank, Ildar T. Bayazitov, Stanislav S. Zakharenko, Amar Gajjar, Andrew Davidoff Richard J. Gilbertson: A perivascular niche for brain tumor stem cells. Cancer Cell 11:69-82 (2007) (Pubitemid 46054518)
44. Chris Folkins, Shan Man, Ping Xu, Yuval Shaked, Daniel J. Hicklin, Robert S. Kerbel: Therapies combining a targeted antiangiogenic drug and cytotoxic or metronomic chemotherapy reduce the tumor-stem like fraction in glioma xenograft tumors. Cancer Res 11, 69-82 (2007)
45. John J Kim, Ian F Tannok: Repopulation of cancer cells during therapy: an important cause of treatment failure. Nat Rev Cancer 5, 516-525 (2005) (Pubitemid 40942828)
46. Yuval Shaked, Alessia Ciarrocchi, Marcela Franco, Christina R. Lee, Shan Man, Alison M. Cheung, Daniel J. Hicklin, David Chaplin, F. Stuart Foster, Robert Benezra, Robert S. Kerbel: Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313, 1785-1787 (2006) (Pubitemid 44454154)
47. Robert S Kerbel, Barton A Kamen: The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 4, 423-436 (2004) (Pubitemid 38745528)
48. Yuval Shaked, Robet S. Kerbel: Antiangiogenic strategies on defence: On the possibility of bloking rebounds by the tumor vasculature after chemotherapy. Cancer Res 67, 7055-7058 (2007) (Pubitemid 47206528)
49. Napoleone Ferrara, Robert S Kerbel: Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005) (Pubitemid 43093963)
50. Rakesh K Jain: Tumor angiogenesis and accessibility: role of vascular endothelial growth factor. Semin Oncol 29(Suppl 16), 3-9 (2002)
51. Jade Homsi, Adil I. Daud: Spectrum of Activity and Mechanism of Action of VEGF/PDGF Inhibitors. Cancer Control 14, 285-294 (2007) (Pubitemid 47057799)
52. Andreas E Roussidis, AD Theocharis, GN Tzanakakis, Nikos K Karamanos: The importance of c-Kit and PDGF receptors as potential targets for molecular therapy in breast cancer. Curr Med Chem. 14:735-743 (2007) (Pubitemid 46477708)
53. Roy M. Bremnes, Carlos Camps, Rafael Sirera: Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 51, 143-158 (2006) (Pubitemid 43144358)
54. Robert J. Motzer, M. Dror Michaelson, Bruce G. Redman, Gary R. Hudes, George Wilding, Robert A. Figlin, Michelle S. Ginsberg, Sindy T. Kim, Charles M. Baum, Samuel E. De Primo, Jim Z. Li, Carlo L. Bello, Charles P. Theuer, Daniel J. George, Brian I. Rini: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 24, 16-24 (2006) (Pubitemid 46630489)
55. Anat Norden-Zfoni, Jayesh Desai, Judith Manola, Paul Beaudry, Jeremy Force, Robert Maki, Judah Folkman, Carlo Bello, Charles Baum, Sam E. De Primo, David R. Shalinsky, Goerge D. Demetri, John V. Heymach: Bloodbased biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor. Clin Cancer Res 13, 2643-2650 (2007) (Pubitemid 46788031)
56. Darren R. Feldman, Andrew J. Martorella, Richard J. Robbins, Robert J. Motzer: Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst. 99, 974-975 (2007) (Pubitemid 47073505)
57. Judy R. van Beijnum, Ruud P. Dings, Edith van der Linden, Bernadette M. M. Zwaans, Frans C. S. Ramaekers, Kevin H. Mayo, Arjan W. Griffioen: Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature. Blood 108, 2339-2348 (2006) (Pubitemid 44497518)
58. Steven Seaman, Janine Stevens, Mi Young Yang, Daniel Logsdon, Cari Graff-Cherry, Brad St. Croix: Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 11, 539-554 (2007) (Pubitemid 46856908)
59. Cristina Rabascio, Elisabetta Muratori, Patrizia Mancuso, Angelica Calleri, Valentina Raia, Thomas Foutz, Saverio Cinieri, Giulia Veronesi, Giancarlo Pruneri, Pietro Lampertico, Massimo Iavarone, Giovanni Martinelli, Aron Goldhirsch, Francesco Bertolini: Assessing tumor angiogenesis: increased circulating VE-cadherin RNA in patients with cancer indicates viability of circulating endothelial cells. Cancer Res 64, 4373-4377 (2004) (Pubitemid 38802446)
60. Edward H. Lin, Manal Hassan, Yanan Li, Hua Zhao, Ajay Nooka, Elizabeth Sorenson, Keping Xie, Richard Champlin, Xifeng Wu, Donghui Li: Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence. Cancer 110, 534-542 (2007) (Pubitemid 47106141)
61. Niven Mehra, Maarten Penning, Jolanda Maas, Laurens V. Beerepoot, Nancy van Daal, Carla H. van Gils, Rachel H. Giles, Emile E. Voest: Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases. Clin Cancer Res 12, 4859-4866 (2006) (Pubitemid 44338571)
62. Daniel Freund, Nicola Bauer, Sabine Boxberger, Silvia Feldmann, Uwe Streller, Gerhard Ehninger, Carsten Werner, Martin Bornhauser, Joachim Oswald, Denis CorbeilPolarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells: effects on proliferation and clonogenicity. Stem Cells Dev 15, 815-829 (2006) (Pubitemid 46147854)
63. Bart Rountree, Lora Barsky, Shundi Ge, Judy Zhu, Shantha Senadheera, Gay M. Crooks: A CD133-Expressing Murine Liver Oval Cell Population with Bilineage Potential. Stem Cells 25, 2419-2429 (2007) (Pubitemid 47582734)
64. Patrizia Mancuso, Alessandra Burlini, Gianfranco Pruneti, Aron Goldhirsch, Giovanni Martinelli, Francesco Bertolini: Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood 97, 3658-3661 (2001)
65. Hong Zhang, Varsha Vakil, Marc Braunstein, Eric L. P. Smith, Justin Maroney, Laurie Chen, Kezhi Dai, James R. Berenson, M. Mahmood Hussain, Uwe Klueppelberg, Allen J. Norin, Hasan O. Akman, Tayfun Özçelik, Olcay A. Batuman: Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood 105, 3286-3294 (2005)
66. Gerhard Fürstenberger, R von Moos, R Lucas, B Thürlimann, H-J Sen, J Hamacher, E-M Boneberg: Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer. Br J Cancer 94, 524-531 (2006) (Pubitemid 43289756)
67. Silvia Monestiroli, Patrizia Mancuso, Alessandra Burlini, Giancarlo Pruneri, Chiara Dell'Agnola, Alberto Gobbi, Giovanni Martinelli and Francesco Bertolini: Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma. Cancer Res 61, 4341-4344 (2001) (Pubitemid 32685756)
68. Patrizia Mancuso, Marco Colleoni, Angelica Calleri, Laura Orlando, Patrick Maisonneuve, Giancarlo Pruneri, Alice Agliano, Aron Goldhirsch, Yuval Shaked, Robert S. Kerbel, Francesco Bertolini: Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy. Blood 108, 452-459 (2006) (Pubitemid 44061341)
69. Francesco Bertolini, Saki Paul, Patrizia Mancuso, Silvia Monestiroli, Alberto Gobbi, Yuval Shaked, Robert S. Kerbel: Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 63, 4342-4346 (2003) (Pubitemid 36951001)
70. David Lyden, Koichi Hattori, Sergio Dias, Carla Costa, Pamela Blaikie, Linda Butros, Amy Chadburn, Beate Heissig, Willy Marks, Larry Witte, Yan Wu, Daniel Hicklin, Zhenping Zhu, Neil R. Hackett, Ronald G. Crystal, Malcolm A. S. Moore, Katherine A. Hajjar, Katia Manova, Robert Benezra, Shahin Rafii: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7, 1194-1201 (2001) (Pubitemid 33063774)
71. Takayuki Asahara, Toyoaki Murohara, Alison Sullivan, Marcy Silver, Rien van der Zee, Tong Li, Bernhard Witzenbichler, Gina Schatteman, Jeffrey M. Isner: Isolation of putative progenitor endothelial cells for angiogenesis. Science 275, 964-966 (1997)
72. Monica Garcia-Barros, Francois Paris, Carlos Cordon-Cardo, David Lyden, Shahin Rafii, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick: Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis. Science 300, 1155-1159 (2003) (Pubitemid 36583102)
73. Marcia Regina Machein, Renninger S, de Lima-Hahn E, Plate KH: Minor contribution of bone marrow-derived endothelial progenitors to the vascularization of murine gliomas. Brain Pathol 13, 582-597 (2003) (Pubitemid 37420701)
74. Iiro Rajantie, Maritta Ilmonen, Agne Alminaite, Ugur Ozerdem, Kari Alitalo, Petri Salven: Adult bone marrowderived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood 104, 2084-2086 (2004) (Pubitemid 39297861)
75. Brock A Peters, Luis A Diaz Jr, Kornelia Polyak, Leslie Meszler, Kathy Romans, Eva C Guinan, Joseph H Antin, David Myerson, Stanley R Hamilton, Bert Vogelstein, Kenneth W Kinzler, Christoph Lengauer: Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 11, 261-262 (2005) (Pubitemid 40460552)
76. Robert Voswinckel, Tibor Ziegelhoeffer, Matthias Heil, Sawa Kostin, Georg Breier, Tanja Mehling, Rainer Haberberger, Matthias Clauss, Andreas Gaumann, Wolfgang Schaper, Werner Seeger Circulating vascular progenitor cells do not contribute to compensatory lung growth. Circ Res 93, 372-379 (2003) (Pubitemid 37048250)
77. Joachim R. Göthert, Sonja E. Gustin, J. Anke M. van Eekelen, Uli Schmidt, Mark A. Hall, Stephen M. Jane, Anthony R. Green, Berthold Göttgens, David J. Izon, C. Glenn Begley: Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood, 104, 1769-1777 (2004) (Pubitemid 39202286)
78. Yulong He, Iiro Rajantie, Maritta Ilmonen, Taija Makinen, Marika J. Karkkainen, Paula Haiko, Petri Salven, Kari Alitalo: Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Res 64, 3737-3740 (2004) (Pubitemid 38697279)
79. Bruno Larrivée, Kyle Niessen, Ingrid Pollet, Stéphane Y. Corbel, Michael Long, Fabio M. Rossi, Peggy L. Olive, Aly Karsan: Minimal contribution of marrow-derived endothelial precursors to tumor vasculature. J Immunol 175, 2890-2899 (2005) (Pubitemid 41170506)
80. Marianna B. Ruzinova, Rebecca A. Schoer, William Gerald, James E. Egan, Pier Paolo Pandolfi, Shahin Rafii, Katia Manova, Vivek Mittal, Robert Benezra: Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer Cell 4:277-289 (2003) (Pubitemid 37329792)
81. Haiqing Li, William L. Gerald, Robert Benezra: Utilization of bone marrow-derived endothelial cell precursors in spontaneous prostate tumors varies with tumor grade. Cancer Res 64:6137-6431 (2004)
82. Dan G. Duda, Kenneth S. Cohen, Sergey V. Kozin, Jean Y. Perentes, Dai Fukumura, David T. Scadden, Rakesh K. Jain: Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood 107:2774-2776 (2006)
83. Dingcheng Gao, Daniel J Nolan, Albert S Mellick, Kathryn Bambino, Kevin McDonnell, Vivek Mittal: Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis. Science 319, 195-198 (2008)
84. Brock A Peters, Luis A Diaz Jr, Kornelia Polyak, Leslie Meszler, Kathy Romans, Eva C Guinan, Joseph H Antin, David Myerson, Stanley R Hamilton, Bert Vogelstein, Kenneth W Kinzler, Christoph Lengauer Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nature Medicine 11, 261-262 (2005) (Pubitemid 40460552)
85. Yuval Shaked, Urban Emmenegger, Shan Man, Dave Cervi, Francesco Bertolini, Yaacov Ben-David, and Robert S. Kerbel Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity. Blood 106, 3058-3061 (2005) (Pubitemid 41565900)
86. Nicoletta Ferrari, J. Glod, J. Lee, D. Kobiler, H. A. Fine: Bone marrow-derived, endothelial progenitor-like cells as angiogenesis-selective gene-targeting vectors. Gene Ther. 10, 647-656 (2003) (Pubitemid 36553610)
87. Jiwu Wei, Sabine Blum, Marcus Unger, Gergely Jarmy, Mathias Lamparter, Alber Geishauser, Giogios A. Vlastos, Gordon Chan, Klaus-Dieter Fisher, Dirk Rattat, Klaus-Michael Debatin, Antinis K Hartzopuolos, Christian Beltinger: Embryonic endothelial progenitors cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell 5, 477-490 (2004)
88. Robert S. Kerbel: Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 13, 31-36 (1991) (Pubitemid 21892580)
89. Dean W. Felsher, J. Michael Bishop: Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc. Natl. Acad. Sci. USA 96, 3940-3944 (1999) (Pubitemid 29169015)
90. Kyoko Hida, Yasuhiro Hida, Dhara N. Amin, Alan F. Flint, Dipak Panigrahy, Cynthia C. Morton, Michael Klagsbrun: Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 64, 8249-8255 (2004) (Pubitemid 39491762)
91. Berthold Streubel, Andreas Chott, Daniela Huber, Markus Exner, Ulrich Jäger Oswald Wagner, Ilse Schwarzinger: Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. N Engl J Med. 351, 250-259 (2004) (Pubitemid 38916042)
92. Gian Matteo Rigolin, Chiara Fraulini, Maria Ciccone, Endri Mauro, Anna Maria Bugli, Cristiano De Angeli, Massimo Negrini, Antonio Cuneo, Gianluigi Castoldi: Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion. Blood 107, 2531-25351 (2006)
93. Gian Matteo Rigolin, Endri Mauro, Maria Ciccone, Chiara Fraulini, Olga Sofritti, Gianluigi Castoldi, Antonio Cuneo: Neoplastic circulating endothelial-like cells in patients with acute myeloid leukaemia. Eur J Haematol. 78, 365-373 (2007) (Pubitemid 46558201)
94. Anna Bergsmedh, Anna Szelesdagger, Marie Henrikssondagger, Anders Bratt, Judah Folkman, Anna-Lena Spetz, Lars Holmgren: Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc. Natl Acad. Sci. USA 98, 6407-6411 (2001) (Pubitemid 32488250)
95. K Mortensen, J Lichtenberg, PD Thomsen, LI Larsson: Spontaneous fusion between cancer cells and endothelial cells. Cell. Mol. Life Sci. 61, 2125-2131 (2004) (Pubitemid 39149901)
96. Britta Weigelt, Johannes L. Peterse, Laura J. van't Veer: Breast cancer metastasis: Markers and models. Nat Rev Cancer, 5, 591-602 (2005) (Pubitemid 41081385)
97. Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii, David Lyden: VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature, 438, 820-827 (2005) (Pubitemid 41753060)
98. Richard J Glibertson, Jeremy N. Rich: Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 7, 733-736 (2007) (Pubitemid 47463683)