Extension arm facilitated pegylation of αα-hemoglobin with modifications targeted exclusively to amino groups: Functional and structural advantages of free cys-93(β) in the PEG-Hb adduct

Bioconjugate Chemistry

Volumn 20, Issue 11, 2009, Pages 2062-2070

  Li, Dongxia ^a   Hu, Tao ^a   Manjula, Belur N ^a   Acharya, Seetharama A ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN; PORPHYRINS; SULFUR COMPOUNDS;

AMINO GROUP; CROSS LINKING; FUNCTIONAL PROPERTIES; HAEMOGLOBINS; HEME POCKETS; HEMOGLOBIN ADDUCTS; OXY-HEMOGLOBIN; OXYGEN AFFINITY; PEGYLATION; STRUCTURAL ADVANTAGE;

HEMOGLOBIN;

4 THIOPYRIDINE; ALPHAALPHA FUMARYL CROSS LINKED HEMOGLOBIN; AMINO ACID; CYSTEINE; DEOXYHEMOGLOBIN; DISULFIDE; FUNCTIONAL GROUP; HEME; HEMOGLOBIN; LYSINE; MACROGOL; MALEIMIDE; OXYGEN; OXYHEMOGLOBIN; PEGHEMOGLOBIN; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; AUTOOXIDATION; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONJUGATION; CONTROLLED STUDY; CROSS LINKING; DRUG DESIGN; DRUG STRUCTURE; EXTENSION ARM FACILITATED PEGYLATION; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; OXYGEN AFFINITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; TECHNIQUE;

EID: 71249139373     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc900170e     Document Type: Article

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