Autoradiographic comparison of muscarinic M1 and M2 binding sites in the CNS of spontaneously hypertensive and normotensive rats

Brain Research

Volumn 771, Issue 2, 1997, Pages 173-183

  Gattu, Mahanandeeshwar ^a   Pauly, James R ^a   Urbanawiz, Shanna ^a   Buccafusco, Jerry J ^a,b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Autoradiography; Blood pressure; Hypothalamus; M1 muscarinic receptor; M2 muscarinic receptor; Medulla; Spontaneously hypertensive rat

Indexed keywords

MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BLOOD PRESSURE REGULATION; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HYPOTHALAMUS; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; AUTORADIOGRAPHY; BLOOD PRESSURE; BRAIN; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM; HYPERTENSION; MALE; MUSCARINIC ANTAGONISTS; PARASYMPATHOLYTICS; PIRENZEPINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, MUSCARINIC;

EID: 0030728371     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00691-4     Document Type: Article

References (47)

1. Arneric S.P., Giuliano R., Ernsberger P., Underwood M.D., Reis D.J. Synthesis, release and receptor binding of acetylcholine in the C1 area of the rostral ventrolateral medulla: contributions in regulating arterial pressure. Brain Res. 511:1990;98-112.
2. 1 noradrenergic cells. Brain Res. 253:1982;161-171.
3. Brezenoff H.E., Giuliano R. Cardiovascular control by cholinergic mechanisms in the central nervous system. Annu. Rev. Pharmacol. Toxicol. 22:1982;341-381.
4. Buccafusco J.J. Neuropharmacologic and behavioral actions of clonidine: interactions with central neurotransmitters. Int. Rev. Neurobiol. 33:1992;55-107.
5. Buccafusco J.J. The role of central cholinergic neurons in the regulation of blood pressure and in experimental hypertension. Pharmacol. Rev. 48:1996;179-211.
6. Buccafusco J.J., Brezenoff H.E. The hypertensive response to injection of physostigmine into the hypothalamus of the unanesthetized rat. Clin. Exp. Hypertens. 1:1978;219-227.
7. Buccafusco J.J., Brezenoff H.E. Pharmacological study of a cholinergic mechanism within the rat posterior hypothalamic nucleus which mediated a hypertensive response. Brain Res. 165:1979;295-310.
8. Buccafusco J.J., Brezenoff H.E. Brain neurotransmitters and the development and maintenance of hypertension. Prog. Drug Res. 30:1986;127-150.
9. Buccafusco J.J., Spector S. Role of central cholinergic neurons in experimental hypertension. J. Cardiovascular Pharmacol. 2:1980;347-355.
10. Buccafusco J.J., Makari N.F., Hays A.C. Pharmacological analysis of the enhanced pressor response to central cholinergic stimulation in spontaneously hypertensive rats. Jpn. J. Pharmacol. 54:1990;105-112.
11. Cantor E.H., Abraham S., Spector S. Central neurotransmitter receptors in hypertensive rats. Life Sci. 28:1981;519-526.
12. Caufield M.P. Muscarinic receptors-characterization, coupling and function. Pharmacol. Ther. 58:1993;319-379.
13. Chozick B.S. The behavioral effects of lesions of the amygdala: a review. Int. J. Neurosci. 29:1986;205-221.
14. Dampney R.A.L. Functional organization of central pathways regulating the cardiovascular system. Pharmacol. Rev. 74:1994;323-364.
15. Gattu M., Wei J., Pauly J.R., Urbanawiz S.E., Buccafusco J.J. Increased expression of M2 muscarinic receptor mRNA and binding sites in the rostral ventrolateral medulla of spontaneously hypertensive rats. Brain Res. 756:1997;125-132.
16. Giuliano R., Brezenoff H.E. Increased central cholinergic activity in rat models of hypertension. J. Cardiovasc. Pharmacol. 10:1987;113-122.
17. Giuliano R., Ruggiero D.A., Morrison S., Ernsberger P., Reis D.J. Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla. J. Neurosci. 9:1989;923-942.
18. Gotoh M., Smythe G.A. Effects of intracerebroventricularly administered neostigmine on sympathetic neural activities of peripheral tissue in rats. Brain Res. 548:1991;32-328.
19. Helke C.J., Muth E.A., Jacobowitz D.M. Changes in central cholinergic neurons in the spontaneously hypertensive rat. Brain Res. 188:1980;425-436.
20. Hershkowitz M., Eliash S., Cohen S. The muscarinic cholinergic receptors in the posterior hypothalamus of hypertensive and normotensive rats. Eur. J. Pharmacol. 86:1983;229-236.
21. Hoffman W.E., Schmid P.G., Phillips M.I. Central cholinergic and noradrenergic stimulation in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 206:1978;644-651.
22. Kubo T., Tatsumi M. Increased pressor response to physostigmine in spontaneously hypertensive rats. Naunyn Schmiedebergs Arch. Pharmacol. 306:1979;81-83.
23. Magri V., Buccafusco J.J. Hypertension following intrathecal injection of cholinergic agonists in conscious rats: Role of endogenous acetylcholine. J. Auton. Nerv. Syst. 25:1988;69-77.
24. 2 muscarine receptors in the rat brain. Neuroscience. 19:1986;551-564.
25. McCaughran J.A. Jr., Murphy D., Schecter N., Friedmen R. Participation of the central cholinergic system in blood pressure regulation in the Dahl rat model of essential hypertension. J. Cardiovasc. Pharmacol. 5:1983;1005-1009.
26. Murugaian J., Sundaram K., Sapru H. Cholinergic mechanisms in the ventrolateral depressor area. Brain Res. 501:1989;355-363.
27. Pauly J.R., Stitzel J.A., Marks M.J., Collins A.C. An autoradiographic analysis of cholinergic receptors in mouse brain. Brain. Res. Bull. 22:1989;453-459.
28. Pauly J.R., Marks M.J., Gross S.D., Collins A.C. An autoradiographic analysis of nicotinic cholinergic receptors in mouse brain following chronic nicotine infusion. J. Pharmacol. Exp. Ther. 258:1991;1127-1136.
29. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1986.
30. Pazo J.H., Medina J.H. Cholinergic mechanisms within the caudate nucleus mediate changes in blood pressure. Neuropharmacology. 22:1983;717-720.
31. 2 receptor subtype. Eur. J. Pharmacol. 125:1986;63-70.
32. Philippu A. Involvement of cholinergic systems of the brain in the central regulation of cardiovascular functions. J. Auton. Pharmacol. 1:1981;321-330.
33. 2-like receptor sub-type. Neuroscience. 29:1989;271-289.
34. Ruggiero D.A., Giuliano R., Anwar M., Stornetta R., Reis D.J. Anatomical substrates of cholinergic-autonomic regulation in the rat. J. Comp. Neurol. 292:1990;1-53.
35. 2 muscarinic acetylcholine receptor distribution in the rat brain: relation to cholinergic nuclei and projections. Brain Res. 380:1986;59-68.
36. 2 muscarinic receptors mediate pressor responses to cholinergic agonists in the ventrolateral medullary pressor area. Brain Res. 449:1988;141-149.
37. Sundaram K., Sapru H. Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacological evidence. J. Auton. Nerv. Syst. 22:1988;221-228.
38. R.C. Switzer, J. De Olmos, L. Heimer, Olfactory system, in: G. Paxinos (Ed.), The Rat Nervous System, Academic Press, New York, 1985, pp. 1-36.
39. Trimarchi G.R., Buccafusco J.J. Changes in regional brain synaptosomal high affinity choline uptake during the development of hypertension in spontaneously hypertensive rats. Neurochem. Res. 12:1987;247-254.
40. Varagić V.M., Prostran M.S., Stepanovic S., Savic J., Vujnov S. Transmitter interactions in the central cholinergic control of blood pressure regulation. Drug Metab. Drug Interact. 9:1991;49-76.
41. Wei J., Milici A., Buccafusco J.J. Alterations in the expression of the genes encoding specific muscarinic receptor subtypes in the hypothalamus of spontaneously hypertensive rats. Circ. Res. 76:1995;142-146.
42. Willette R.N., Barcas P.P., Krieger A.J., Sapru H.N. Vasopressor and depressor areas in the rat medulla: identification by microinjection of L-glutamate. Neuropharmacology. 22:1983;1071-1079.
43. Willette R.N., Krieger A.J., Barcas P.P., Sapru H.N. Medullary GABA receptors and the regulation of blood pressure in the rat. J. Pharmacol. Exp. Ther. 226:1983;893-899.
44. Willette R.N., Punnen S., Krieger A.J., Sapru H.N. Cardiovascular control by cholinergic mechanisms in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 231:1984;457-463.
45. Wolf N.J. Cholinergic systems in mammalian brain and spinal cord. Prog. Neurobiol. 37:1991;475-524.
46. Yamada S., Kagawa Y., Ushijima H., Takayanagi N., Tomita T., Hayashi E. Brain nicotinic cholinoceptor binding in spontaneous hypertension. Brain Res. 410:1987;212-218.
47. Y. Yamori, Neurogenic mechanisms of spontaneous hypertension, in: G. Onesti, M. Fernandes, K.E. Kim (Eds.), Regulation of Blood Pressure by the Central Nervous System, Grune and Stratton, New York, 1976, pp. 65-76.