Efficient site-specific radiolabeling of a modified C2A domain of synaptotagmin I with [99mTc(CO)3]+: A new radiopharmaceutical for imaging cell death

Bioconjugate Chemistry

Volumn 20, Issue 11, 2009, Pages 2071-2081

  Tavaré, Richard ^a   De Rosales, Rafael Torres Martin ^a   Blower, Philip J ^a   Mullen, Gregory E D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CALCIUM; CELL DEATH; IMAGE PROCESSING; MASS SPECTROMETRY; PROTEINS; RHENIUM COMPOUNDS; SIZE EXCLUSION CHROMATOGRAPHY;

C-TERMINAL SEQUENCES; HIS-TAG; LABELINGS; LYSINE RESIDUES; PHOSPHATIDYLSERINE; RADIOCHEMICAL YIELD; RADIOLABELLING; RED BLOOD CELL; SITE-SPECIFIC; SYNAPTOTAGMINS;

AMINO ACIDS;

5 MALEIMIDOFLUORESCEIN; CALCIUM; CYSTEINE; FLUORESCEIN; HEXAHISTIDINE; IODOACETAMIDE; LYSINE; MALEIMIDE; N (BENZYLOXYCARBONYLOXY)SUCCINIMIDE; PEPTIDE; PHOSPHATIDYLSERINE; POLYHISTIDINE TAG; RADIOPHARMACEUTICAL AGENT; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN C2AC; RECOMBINANT PROTEIN C2AC IODOACETAMIDE CONJUGATE; RECOMBINANT PROTEIN C2AC N (BENZYLOXYCARBONYLOXY)SUCCINIMIDE CONJUGATE; RECOMBINANT PROTEIN C2ACH; RECOMBINANT PROTEIN C2ACH IODOACETAMIDE CONJUGATE; RECOMBINANT PROTEIN C2ACH N (BENZYLOXYCARBONYLOXY)SUCCINIMIDE CONJUGATE; RHENIUM; RHENIUM TRICARBONYL; SYNAPTOTAGMIN I; TECHNETIUM 99M; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CONJUGATE; CONTROLLED STUDY; DRUG BINDING; DRUG STABILITY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ERYTHROCYTE; FLOW CYTOMETRY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; IMAGING; IMMUNOFLUORESCENCE; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RADIOCHEMISTRY; RAT; SERUM; SYNTHESIS;

RATTUS;

EID: 71249104704     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc900160j     Document Type: Article

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