Detection of apoptosis using the C2A domain of synaptotagmin I

Bioconjugate Chemistry

Volumn 15, Issue 5, 2004, Pages 983-987

  Jung, Hyo Il ^a,b   Kettunen, Mikko I ^a   Davletov, Bazbek ^a,c   Brindle, Kevin M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Yonsei University   (South Korea)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; IRON OXIDES; MAGNETIC RESONANCE IMAGING; METAL NANOPARTICLES; NANOMAGNETICS; PROTEINS;

ANNEXINS; APOPTOTIC CELLS; FUSION PROTEINS; OPTICAL IMAGING TECHNIQUE; PERFORMANCE; PHOSPHATIDYLSERINE; PROBE MOLECULES; STREPTAVIDIN; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; SYNAPTOTAGMINS;

CELL DEATH;

AVIDIN; FLUORESCEIN; GADOLINIUM; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IRON OXIDE; LIPOCORTIN 5; NANOPARTICLE; PHOSPHATIDYLSERINE; RADIOISOTOPE; STREPTAVIDIN; SYNAPTOTAGMIN; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOTINYLATION; FLOW CYTOMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OPTICS; PROTEIN BINDING; PROTEIN DOMAIN;

EID: 4644246936     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc049899q     Document Type: Article

References (25)

1. Heemels, M.-T. (2000) Apoptosis. Nature 407, 769.
2. Meyn, R. E., Stephens, L. C., Ang, K. K., Hunter, N. R., Brock, W. A., Milas, L., and Peters, L. J. (1993) Heterogeneity in apoptosis development in irradiated murine tumours of different histologies. Int. J. Radiat. Biol. 64, 583-591.
3. Meyn, R. E., Stephens, L. C., Hunter, N. R., and Milas, L. (1995) Apoptosis in murine tumours treated with chemotherapy agents. Anti-Cancer Drugs 6, 443-450.
4. Chang, J., Ormerod, M., Powles, T. J., Allred, D. C., Ashley, S. E., and Dowsett, M. (2000) Apoptosis and proliferation as predictors of chemotherapy response in patients with breast carcinoma. Cancer 2145-2152.
5. Dubray, B., Breton, C., Delic, J., Klijanienko, J., Maciorowski, Z., Vielh, P., Forquet, A., Dumont, J., Magdelenat, H., and Cosset, J. M. (1998) In vitro radiation-induced apoptosis and early response to low-dose radiotherapy in non-Hodgkin's lymphomas. Radiother. Oncol. 46, 185-191.
6. Hakumäki, J. M., and Brindle, K. M. (2003) Visualising apoptosis by nuclear magnetic resonance. Trends Pharmacol. Sci. 24, 146-149.
7. Brindle, K. M. (2002) Detection of apoptosis using magnetic resonance imaging and spectroscopy. Adv. Enzyme Regul. 42, 101-112.
8. Saraste, A., and Pulkki, K. (2000) Morphologic and biochemical hallmarks of apoptosis. Cardiovasc. Res. 45, 528-537.
9. Martin, S. J., Reutelingsperger, C. P. M., McGahon, A. J., Rader, J. A., Vanschie, R. C. A. A., LaFace, D. M., and Green, D. R. (1995) Early redistribution of plasma-membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus-Inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182, 1545-1556.
10. Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsperger, C. (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184, 39-51.
11. Blankenberg, F. G., Katsikis, P. D., Tait, J. F., Davis, R. E., Naumovski, L., Ohtsuki, K., Kopiwoda, S., Abrams, M. J., Darkes, M., Robbins, R. C., Maecker, H. T., and Strauss, H. W. (1998) In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 95, 6349-6354.
12. Petrovsky, A., Schellenberger, E., Josephson, L., Weissleder, R., and Bogdanov, A. (2003) Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 63, 1936-1942.
13. Zhao, M., Beauregard, D. A., Loizou, L., Davletov, B., and Brindle, K. M. (2001) Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat. Med. 7, 1241-1244.
14. 2+/phospholipid binding. J. Biol. Chem. 268, 26 386-26 390.
15. Artemov, D., Mori, N., Ravi, R., and Bhujwalla, Z. (2003) Magnetic resonance molecular imaging of the HER-2/neu receptor1. Cancer Res 63, 2723-2727.
16. Saenko, E., Sarafanov, A., Ananyeva, N., Behre, E., Shima, M., Schwinn, H., and Josic, D. (2001) Comparison of the properties of phospholipid surfaces formed on HPA and L1 biosensor chips for the binding of the coagulation factor VIII. J. Chromatogr. 921, 49-56.
17. 2+-dependent membrane binding of C2AB domain of synaptotagmin. FEBS Lett. 527, 22-26.
18. 2+ and assembly with the core SNARE complex onto membranes. Neuron 24, 363-376.
19. Tait, J., Gibson, D., and Fujikawa, K. (1989) Phospholipid binding properties of human placental anticoagulant Protein-I, a member of the lipocortin family. J. Biol. Chem. 264, 7944-7949.
20. Zhang, X., Rizo, J., and Sudhof, T. (1998) Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry 37, 12395-12403.
21. Davletov, B., Perisic, O., and Williams, R. L. (1998) Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically. J. Biol. Chem. 273, 19093-19096.
22. Schellenberger, E., Bogdanov, A., Hogemann, D., Tait, J., Weissleder, R., and Josephson, L. (2002) Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol. Imaging 1, 102-107.
23. Artemov, D., Mori, N., Okollie, B., and Bhujwalla, Z. M. (2003) MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles. Magn. Reson. Med. 49, 403-408.
24. Wiener, E. C., Brechbiel, M. W., Brothers, H., Magin, R. L., Gansow, O. A., Tomalia, D. A., and Lauterbur, P. C. (1994) Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents. Magn. Reson. Med. 31, 1-8.
25. Paganelli, G., Bartolomei, M., Ferrari, M., Cremonesi, M., Broggi, G., Maira, G., Sturiale, C., Grana, C., Frisco, G., Gatti, M., Caliceti, P., and Chinol, M. (2001) Pre-targeted locoregional radioimmunotherapy with 90Y-biotin in glioma patients: Phase I study and preliminary therapeutic results. Cancer Biother. Radiopharm. 16, 227-235.