Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae

Nucleic Acids Research

Volumn 37, Issue 19, 2009, Pages 6429-6438

  Moore, Destaye M ^a   Karlin, Justin ^a   González Barrera, Sergio ^b   Mardiros, Armen ^a   Lisby, Michael ^c   Doughty, Ana ^d   Gilley, Jennifer ^d   Rothstein, Rodney ^b   Friedberg, Errol C ^d   Fischhaber, Paula L ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

^b Department of Medicine   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DOUBLE STRANDED DNA; FUNGAL DNA; MRE11 PROTEIN; PROTEIN RAD10; RAD51 PROTEIN; RAD52 PROTEIN; TYPE I SITE SPECIFIC DEOXYRIBONUCLEASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING MOTIF; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; FUNGAL STRAIN; IONIZING RADIATION; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE;

DNA BREAKS, DOUBLE-STRANDED; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SINGLE-STRAND SPECIFIC DNA AND RNA ENDONUCLEASES;

SACCHAROMYCES CEREVISIAE;

EID: 71049127354     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp709     Document Type: Article

References (36)

1. Friedberg,E.C. (2003) DNA damage and repair. Nature, 421, 436-440.
2. Krogh,B.O. and Symington,L.S. (2004) Recombination proteins in yeast. Annu. Rev. Genet., 38, 233-271.
3. San Filippo,J., Chi,P., Sehorn,M.G., Etchin,J., Krejci,L. and Sung,P. (2006) Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. J. Biol. Chem., 281, 11649-11657.
4. Lisby,M., Barlow,J.H., Burgess,R.C. and Rothstein,R. (2004) Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins. Cell, 118, 699-713.
5. Lisby,M. and Rothstein,R. (2004) DNA repair: Keeping it together. Curr. Biol., 14, R994-996.
6. Friedberg,E.C., Walker,G.C., Siede,W., Wood,R.D., Schultz,R.A. and Ellenberger,T. (2005) DNA Repair and Mutagenesis, 2nd edn. ASM Press, Washington, DC.
7. Bardwell,A.J., Bardwell,L., Tomkinson,A.E. and Friedberg,E.C. (1994) Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease. Science, 265, 2082-2085.
8. Lee,K. and Lee,S.E. (2007) Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics, 176, 2003-2014.
9. Daley,J.M. and Wilson,T.E. (2005) Rejoining of DNA double-strand breaks as a function of overhang length. Mol. Cell Biol., 25, 896-906.
10. Ma,J.L., Kim,E.M., Haber,J.E. and Lee,S.E. (2003) Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol. Cell Biol., 23 8820-8828.
11. Aboussekhra,A. and Al-Sharif,I.S. (2005) Homologous recombination is involved in transcription-coupled repair of UV damage in Saccharomyces cerevisiae. EMBO J., 24, 1999-2010.
12. Ahmad,A., Robinson,A.R., Duensing,A., van Drunen,E., Beverloo,H.B., Weisberg,D.B., Hasty,P., Hoeijmakers,J.H. and Niedernhofer,L.J. (2008) ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol. Cell Biol., 28, 5082-5092.
13. Li,F., Dong,J., Pan,X., Oum,J.H., Boeke,J.D. and Lee,S.E. (2008) Microarray-based genetic screen defines SAW1, a gene required for Rad1/ Rad10-dependent processing of recombination intermediates. Mol. Cell 30, 325-335.
14. Lisby,M. and Rothstein,R. (2004) DNA damage checkpoint and repair centers. Curr. Opin. Cell Biol., 16, 328-334.
15. Reid,R.J., Lisby,M. and Rothstein,R. (2002) Cloning-free genome alterations in Saccharomyces cerevisiae using adaptamer-mediated PCR. Methods Enzymol., 350, 258-277.
16. Bankmann,M., Prakash,L. and Prakash,S. (1992) Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins. Nature, 355, 555-558.
17. Ivanov,E.L. and Haber,J.E. (1995) RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae. Mol. Cell Biol., 15, 2245-2251.
18. Fishman-Lobell,J., Rudin,N. and Haber,J.E. (1992) Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated. Mol. Cell Biol., 12, 1292-1303.
19. Harris,D.C. (2007) Quantitative Chemical Analysis, 7th edn. W. H. Freeman and Co., New York.
20. Lisby,M., Mortensen,U.H. and Rothstein,R. (2003) Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre. Nat. Cell Biol., 5, 572-577.
21. Barlow,J.H., Lisby,M. and Rothstein,R. (2008) Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol. Cell 30, 73-85.
22. Ivanov,E.L., Sugawara,N., Fishman-Lobell,J. and Haber,J.E. (1996) Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae. Genetics, 142, 693-704.
23. Mieczkowski,P.A., Lemoine,F.J. and Petes,T.D. (2006) Recombination between retrotransposons as a source of chromosome rearrangements in the yeast Saccharomyces cerevisiae. DNA Repair (Amst), 5, 1010-1020.
24. Ira,G. and Haber,J.E. (2002) Characterization of RAD51-independent break-induced replication that acts preferentially with short homologous sequences. Mol. Cell Biol., 22, 6384-6392.
25. Fishman-Lobell,J. and Haber,J.E. (1992) Removal of nonhomologous DNA ends in double-strand break recombination: The role of the yeast ultraviolet repair gene RAD1. Science, 258, 480-484.
26. Davis,A.P. and Symington,L.S. (2004) RAD51-dependent break-induced replication in yeast. Mol. Cell Biol., 24, 2344-2351.
27. Lundblad,V. and Blackburn,E.H. (1993) An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell, 73, 347-360.
28. Dong,Z. and Fasullo,M. (2003) Multiple recombination pathways for sister chromatid exchange in Saccharomyces cerevisiae: Role of RAD1 and the RAD52 epistasis group genes. Nucleic Acids Res., 31, 2576-2585.
29. Smith,C.E., Lam,A.F. and Symington,L.S. (2009) Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase {delta} complex. Mol. Cell Biol., 29, 1432-1441.
30. Kang,L.E. and Symington,L.S. (2000) Aberrant double-strand break repair in rad51 mutants of Saccharomyces cerevisiae. Mol. Cell Biol., 20, 9162-9172.
31. Gangloff,S., Soustelle,C. and Fabre,F. (2000) Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases. Nat. Genet., 25, 192-194.
32. Shor,E., Gangloff,S., Wagner,M., Weinstein,J., Price,G. and Rothstein,R. (2002) Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae. Genetics, 162, 647-662.
33. Motycka,T.A., Bessho,T., Post,S.M., Sung,P. and Tomkinson,A.E. (2004) Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52. J. Biol. Chem., 279, 13634-13639.
34. Weiss,W.A. and Friedberg,E.C. (1985) Molecular cloning and characterization of the yeast RAD10 gene and expression of RAD10 protein in E. coli. EMBO J., 4, 1575-1582.
35. Thomas,B.J. and Rothstein,R. (1989) Elevated recombination rates in transcriptionally active DNA. Cell, 56, 619-630.
36. Zhao,X., Muller,E.G. and Rothstein,R. (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell, 2, 329-340.