15(S)-lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: Evidence of lipid droplet metabolism

Journal of Lipid Research

Volumn 50, Issue 12, 2009, Pages 2371-2376

  Weibel, Ginny L ^a   Joshi, Michelle R ^a   Wei, Cong ^b   Bates, Sandra R ^b   Blair, Ian A ^b   Rothblat, George H ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cholesterol; Cholesteryl ester; Lipoxygenases

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; FAT DROPLET; LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ARTICLE; AUTOOXIDATION; CELL DIFFERENTIATION; CELL FREE SYSTEM; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; FOAM CELL; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIPID METABOLISM; MONOCYTE; NONHUMAN; PRIORITY JOURNAL;

ARACHIDONATE 15-LIPOXYGENASE; FOAM CELLS; HUMANS; LIPID METABOLISM; LIPIDS; TUMOR CELLS, CULTURED;

EID: 70849136912     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M900081-JLR200     Document Type: Article

References (33)

1. Beckman, M. 2006. Great balls of fat. Science. 311: 1232-1234.
2. Martin, S., and R. G. Parton. 2006. Lipid droplets: a unified view of a dynamic organelle. Nat. Rev. Mol. Cell Biol. 7: 373-378.
3. Brasaemle, D. L. 2007. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lypolysis. J. Lipid Res. 48: 2547-2559.
4. Ozeki, S., J. Cheng, K. Tauchi-Sato, N. Hatano, H. Taniguchi, and T. Fujimoto. 2005. Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J. Cell Sci. 118: 2601-2611.
5. Bozza, P. T., and C. Bandeira-Melo. 2005. Mechanisms of leukocyte lipid body formation and function in inflammation. Mem. Inst. Oswaldo Cruz. 100: 113-120.
6. Fisher, K. A., K. Van Leyen, K. W. Lovercamp, G. Manandhar, M. Sutovsky, D. Feng, T. Safranski, and P. Sutovsky. 2005. 15-Lipoxygenase is a component of the mammalian sperm cytoplasmic droplet. Reproduction Res. 130: 213-222.
7. Kuhn, H. 2004. Lipoxygenases in the cardiovascular system. Circ. Res. 94: 1527-1529.
8. Wittwer, J., and M. Hersberger. 2007. The two faces of the 15-lipoxygenase in atherosclerosis. Prostaglandins Leukot. Essent. Fatty Acids. 77: 67-77.
9. Belkner, J., R. Wiesner, J. Rathman, J. Barnett, E. Sigal, and H. Kühn. 1993. Oxygenation of lipoproteins by mammalian lipoxygenases. Eur. J. Biochem. 213: 251-261.
10. Cathcart, M. K., A. K. McNally, and G. M. Chisolm. 1991. Lipoxygenase-mediated transformation of human low-density lipoprotein to an oxidized and cytotoxic complex. J. Lipid Res. 32: 63-70.
11. Kühn, H., J. Belkner, S. Zaiss, T. Fährenklemper, and S. Wohlfeil. 1994. Involvement of 15-lipoxygenase in early stages of atherogenisis. J. Exp. Med. 179: 1903-1911.
12. Ylä-Herttuala, S., M. E. Rosenfeld, S. Parthasarathy, C. K. Glass, E. Sigal, J. L. Witztum, and D. Steinberg. 1990. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 87: 6959-6963.
13. Basu, S. K., J. L. Goldstein, R. G. W. Anderson, and M. S. Brown. 1976. Degradation of cationized low-density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fi broblasts. Proc. Natl. Acad. Sci. USA. 73: 3178-3182.
14. Zhu, P., T. Oe, and I. A. Blair. 2008. Determination of cellular redox status by stable isotope dilution liquid chromatograph of glutathione and glutathione disulfide. Rapid Commun. Mass Spectrom. 22: 432-440.
15. DiDonato, D., and D. L. Brasaemle. 2003. Fixation methods for the study of lipid bodies by immunofluorescence microscopy. J. Histochem. Cytochem. 51: 773-780.
16. Dobbs, L. G., M. C. Williams, and R. Gonzalez. 1988. Monoclonal antibodies specific to apical surfaces of rat liver type I cells bind to surfaces of cultured, but not freshly isolated, type II cells. Biochim. Biophys. Acta. 970: 146-156.
17. Madesh, M., B. Antonsson, S. Srinivasula, E. Alnemri, and G. Hajnoczky. 2002. Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J. Biol. Chem. 277: 5651-5659.
18. Adelman, S. J., J. M. Glick, M. C. Phillips, and G. H. Rothblat. 1984. Lipid composition and physical state effects on cellular cholesteryl ester clearance. J. Biol. Chem. 259: 13844-13850.
19. Lee, S. H., M. V. Williams, and I. A. Blair. 2003. Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry. Rapid Commun. Mass Spectrom. 17: 2168-2176.
20. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. 37: 911-917.
21. Zimetti, F., G. K. Weibel, M-N. Duong, and G. H. Rothblat. 2006. Measurement of cholesterol bidirectional flux between cells and lipoproteins. J. Lipid Res. 47: 605-613.
22. Kellner-Weibel, G., P. G. Yancey, W. G. Jerome, T. Walser, R. P. Mason, M. C. Phillips, and G. H. Rothblat. 1999. Crystalization of free cholesterol in model macrophage foam cells. Arterioscler. Thromb. Vasc. Biol. 19: 1891-1898.
23. Stachowska, E., V. Dziedziejko, K. Safranow, K. Jakubowska, M. Olszewska, B. Machalinski, and D. Chlubek. 2007. Effect of conjugated linoleic acids on the activity of mRNA expression of 5-and 15-lipoxygenases in human macrophages. J. Agric. Food Chem. 55: 5335-5342.
24. Conrad, D. J., H. Kuhn, M. Mulkins, E. Highland, and E. Sigal. 1992. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc. Natl. Acad. Sci. USA. 89: 217-221.
25. Brinckmann, R., K. Schnurr, D. Heydeck, T. Rosenbach, G. Kolde, and H. Kühn. 1998. Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme. Blood. 91: 64-74.
26. Habenicht, A. J., P. Salbach, M. Goerig, W. Zeh, U. Janssen-Timmen, C. Blattner, W. C. King, and J. A. Glomset. 1990. The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor. Nature. 345: 634-636.
27. Bryant, R. W., M. Bailey, T. Schewe, and S. M. Rapoport. 1982. Positional specifi city of a reticulocyte lipoxygenase. J. Biol. Chem. 257: 6050-6055.
28. Li, A. C., and C. K. Glass. 2004. PPAR-and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J. Lipid Res. 45: 2161-2173.
29. Kliewer, S. A., S. S. Sundseth, S. A. Jones, P. J. Brown, G. B. Wisely, C. S. Koble, P. Devchand, W. Wahli, T. M. Willson, J. M. Lenhard, et al. 1997. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. USA. 94: 4318-4323.
30. Marcus, A. J. 1984. The eicosanoids in biology and medicine. J. Lipid Res. 25: 1511-1516.
31. Wen, Y., J. Gu, G. E. Vandenhoff, X. Liu, and J. L. Nadler. 2008. Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages. Am. J. Heart Circ. Physiol. 294: 1933-1938.
32. Nagelin, M. H., S. Srinivasan, J. Lee, J. L. Nadler, and C. C. Hedrick. 2008. 12/15-lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. Arterioscler. Thromb. Vasc. Biol. 28: 1811-1819.
33. Ternowitz, T., K. Fogh, and K. Kragballe. 1998. 15-Hydroxyeicosatetraenoic acid (15-HETE) specifically inhibits LTB4-induced chemotaxis of human neutrophils. Skin Pharmacol. 1: 93-99.