Anti-integrin monoclonal antibodies

Journal of Cell Science

Volumn 122, Issue 22, 2009, Pages 4009-4011

  Byron, Adam ^a   Humphries, Jonathan D ^a   Askari, Janet A ^a   Craig, Sue E ^a   Mould, A Paul ^a   Humphries, Martin J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; BETA INTEGRIN; EPITOPE; INTEGRIN; MONOCLONAL ANTIBODY; NATALIZUMAB;

ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; CELL ANCHORAGE; CELL INTERACTION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; IMMUNOPRECIPITATION; LEUKOCYTE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SIGNAL TRANSDUCTION; THROMBOSIS; UNSTABLE ANGINA PECTORIS;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNE DISEASES; EPITOPES; HUMANS; INTEGRINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; THROMBOSIS;

EID: 70849109088     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.056770     Document Type: Article

References (13)

1. Alonso, J. L., Essafi, M., Xiong, J.-P., Stehle, T. and Arnaout, M. A. (2002). Does the integrin αA domain act as a ligand for its βA domain? Curr. Biol. 12, R340-R342.
2. Andrews, M. R., Czvitkovich, S., Dassie, E., Vogelaar, C. F., Faissner, A., Blits, B., Gage, F. H., ffrench-Constant, C. and Fawcett, J. W. (2009). α9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J. Neurosci. 29, 5546-5557.
3. Arnaout, M. A., Mahalingam, B. and Xiong, J.-P. (2005). Integrin structure, allostery, and bidirectional signaling. Annu. Rev. Cell Dev. Biol. 21, 381-410.
4. Artoni, A., Li, J., Mitchell, B., Ruan, J., Takagi, J., Springer, T. A., French, D. L. and Coller, B. S. (2004). Integrin β3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin αIIbβ3 activation. Proc. Natl. Acad. Sci. USA 101, 13114-13120.
5. Humphries, M. J. (2000). Integrin structure. Biochem. Soc. Trans. 28, 311-339.
6. Huryn, D. M., Konradi, A. W., Ashwell, S., Freedman, S. B., Lombardo, L. J., Pleiss, M. A., Thorsett, E. D., Yednock, T. and Kennedy, J. D. (2004). The identification and optimization of orally efficacious, small molecule VLA- 4 antagonists. Curr. Top. Med. Chem. 4, 1472-1484.
7. Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
8. La Merie, S. L. (2009). Top 20 biologics 2008. R&D Pipeline News Special Edition 1, 1-25.
9. Luo, B. H., Carman, C. V. and Springer, T. A. (2007). Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25, 619-647.
10. Mould, A. P., Akiyama, S. K. and Humphries, M. J. (1996). The inhibitory anti-β1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy: evidence for allosteric inhibition of integrin function. J. Biol. Chem. 271, 20365-20374.
11. Wegener, K. L., Partridge, A. W., Han, J., Pickford, A. R., Liddington, R. C., Ginsberg, M. H. and Campbell, I. D. (2007). Structural basis of integrin activation by talin. Cell 128, 171-182.
12. Xiong, J.-P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Goodman, S. L. and Arnaout, M. A. (2001). Crystal structure of the extracellular segment of integrin αVβ3. Science 294, 339-345.
13. Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L. and Arnaout, M. A. (2002). Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand. Science 296, 151-155.