Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease

Clinical and Experimental Immunology

Volumn 159, Issue 1, 2010, Pages 87-92

  Landfried, K ^b   Bataille, F ^a   Rogler, G ^e   Brenmoehl, J ^c   Kosovac, K ^b   Wolff, D ^b   Hilgendorf, I ^d   Hahn, J ^b   Edinger, M ^b   Hoffmann, P ^b   Obermeier, F ^a   Schoelmerich, J ^a   Andreesen, R ^b   Holler, E ^a,b  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b Department of Haematology/Oncology ^*  (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF ROSTOCK   (Germany)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

CD4; Gastrointestinal GVHD; Immunohistology; NOD2 CARD15

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYCLOSPORIN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE;

ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CROHN DISEASE; DNA POLYMORPHISM; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; INTESTINE GRAFT; LAMINA PROPRIA; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR;

ADRENAL CORTEX HORMONES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL MOVEMENT; FORKHEAD TRANSCRIPTION FACTORS; GRAFT VS HOST DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; INTESTINES; MIDDLE AGED; MUCOUS MEMBRANE; NEUTROPHILS; NOD2 SIGNALING ADAPTOR PROTEIN; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; POLYMORPHISM, GENETIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 70749125014     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.04049.x     Document Type: Article

References (27)

1. Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet 2007 369 : 1627 1640.
2. Rogler G. Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 2004 20 : 311 317. (Pubitemid 38813671)
3. van Bekkum DW, Roodenburg J, Heidt PJ, van der WD. Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora. J Natl Cancer Inst 1974 52 : 401 404.
4. Chakraverty R, Cote D, Buchli J et al. An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med 2006 203 : 2021 2031.
5. Gerbitz A, Schultz M, Wilke A et al. Probiotic effects on experimental graft-versus-host disease: let them eat yogurt. Blood 2004 103 : 4365 4367.
6. Holler E, Rogler G, Brenmoehl J et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 2006 107 : 4189 4193.
7. Holler E, Rogler G, Herfarth H et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 2004 104 : 889 894.
8. Hildebrandt GC, Granell M, Urbano-Ispizua A et al. Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2008 14 : 67 74.
9. Van Heel DA, Hunt KA, King K et al. Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease. Inflamm Bowel Dis 2006 12 : 598 605.
10. Zelinkova Z, van Beelen AJ, de Kort F et al. Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells. Inflamm Bowel Dis 2008 14 : 186 194.
11. Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001 411 : 603 606.
12. Wehkamp J, Harder J, Weichenthal M et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004 53 : 1658 1664.
13. Bombi JA, Nadal A, Carreras E et al. Assessment of histopathologic changes in the colonic biopsy in acute graft-versus-host disease. Am J Clin Pathol 1995 103 : 690 695.
14. Sale GE, Shulman HM, McDonald GB, Thomas ED. Gastrointestinal graft-versus-host disease in man. A clinicopathologic study of the rectal biopsy. Am J Surg Pathol 1979 3 : 291 299.
15. Shidham VB, Chang CC, Shidham G et al. Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients. BMC Gastroenterol 2003 3 : 5.
16. Sviland L, Pearson AD, Green MA et al. Immunopathology of early graft-versus-host disease - a prospective study of skin, rectum, and peripheral blood in allogeneic and autologous bone marrow transplant recipients. Transplantation 1991 52 : 1029 1036.
17. Weisdorf SA, Roy J, Snover D, Platt JL, Weisdorf DJ. Inflammatory cells in graft-versus-host disease on the rectum: immunopathologic analysis. Bone Marrow Transplant 1991 7 : 297 301.
18. Rieger K, Loddenkemper C, Maul J et al. Mucosal FOXP3+ regulatory T Cells are numerically deficient in acute and chronic GvHD. Blood 2006 107 : 1717 1723.
19. Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C. Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol 2007 178 : 7032 7041.
20. Zhou H, Wang ZD, Zhu X, You Y, Zou P. CD8+FOXP3+T cells from renal transplant recipients in quiescence induce immunoglobulin-like transcripts-3 and -4 on dendritic cells from their respective donors. Transplant Proc 2007 39 : 3065 3067.
21. Carlson MJ, West ML, Coghill JM, Panoskaltsis-Mortari A, Blazar BR, Serody JS. In vitro differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathology. Blood 2009 113 : 1365 1374.
22. Kappel LW, Goldberg GL, King CG et al. IL-17 contributes to CD4-mediated graft-versus-host disease. Blood 2009 113 : 945 952.
23. Yi T, Zhao D, Lin CL et al. Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood 2008 112 : 2101 2110.
24. van Beelen AJ, Zelinkova Z, Taanman-Kueter EW et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 2007 27 : 660 669.
25. Liu YJ. TSLP in epithelial cell and dendritic cell cross talk. Adv Immunol 2009 101 : 1 25.
26. Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007 204 : 1757 1764.
27. Penack O, Smith OM, Cunningham-Bussel A et al. NOD2 regulates hematopoietic cell function during graft-versus-host disease. J Exp Med 2009 206 : 2101 2110.