Evaluating the role of the serotoninergic system in the control of human seminal vesicle smooth muscle - an in vitro approach

Journal of Sexual Medicine

Volumn 6, Issue 10, 2009, Pages 2672-2679

  Birowo, Ponco ^a   Ückert, Stefan ^a   Kedia, George T ^a   Scheller, Friedemann ^b   Meyer, Markus ^c   Taher, Akmal ^a   Rahardjo, Djoko ^a   Jonas, Udo ^a   Kuczyk, Markus A ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CIPTO MANGUNKUSUMO HOSPITAL   (Indonesia)

^c FOCUS IP AG   (Switzerland)

Author keywords

Cyclic nucleotide monophosphates; Human seminal vesicles; Premature ejaculation; Serotonin; Serotonin re uptake inhibitors

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CLOMIPRAMINE; CYCLIC AMP; CYCLIC GMP; FLUOXETINE; IMIPRAMINE; NORADRENALIN; SEROTONIN; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; SEROTONIN UPTAKE INHIBITOR;

AGED; ARTICLE; BATH; CLINICAL ARTICLE; DOSE RESPONSE; DRUG EFFICACY; HORMONE INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; RADIOIMMUNOASSAY; SEMINAL VESICLE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE TONE; SYMPATHETIC REFLEX; DRUG EFFECTS; EJACULATION; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; SEXUAL DYSFUNCTION; SMOOTH MUSCLE; VAS DEFERENS;

ADRENERGIC ALPHA-AGONISTS; AGED; CLOMIPRAMINE; CYCLIC AMP; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; FLUOXETINE; HUMANS; IMIPRAMINE; IN VITRO TECHNIQUES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NOREPINEPHRINE; SEMINAL VESICLES; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; VAS DEFERENS;

EID: 70649111551     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01423.x     Document Type: Article

References (32)

1. Böhlen D, Hugonnet CL, Mills RD, Weise ES, Schmid HP. Five meters of H2O: The pressure at the urinary bladder neck during human ejaculation. Prostate 2000, 44:339-41.
2. Gil-Vernet JM, Alvarez-Vijande R, Gil-Verne A, Gil-Vernet JM. Ejaculation in men: A dynamic endorectal ultrasonographical study. Br J Urol 1994, 73:442-8.
3. Witt MA, Grantmyre JE. Ejaculatory failure. World J Urol 1993, 11:89-95.
4. Donatucci CF. Etiology of ejaculation and pathophysiology of premature ejaculation. J Sex Med 2006, 3(4):303-8. suppl
5. Sharlip ID. Guidelines for the diagnosis and management of premature ejaculation. J Sex Med 2006, 3:309-17.
6. Montague DK, Jarow J, Broderick GA, Dmochowski RR, Heaton JPW, Lue TF, Nehra A, Sharlip ID. AUA guideline on the pharmacologic management of premature ejaculation. J Urol 2004, 172:290-4.
7. Sadeghi-Nejad H, Watson R. Premature ejaculation: current medical treatment and new directions. J Sex Med 2008, 5:1037-50.
8. Giuliano F, Clèment P. Serotonin and premature ejaculation: from physiology to patient management. Eur Urol 2006, 50:454-66.
9. de Jong TR, Veening JG, Waldinger MD, Cools AR, Olivier B. Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 2006, 30:893-907.
10. Kalyoncu NI, Ozyavuz R, Karaoglu S. Sertraline inhibits the contractile responses to noradrenaline, KCl and electrical field stimulation of rat isolated vas deferens. J Auton Pharmacol 1999, 19:365-9.
11. Ückert S, Bazrafshan S, Scheller F, Meyer ME, Jonas U, Stief CG. Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors. UROLOGY 2007, 70:185-9.
12. Waldinger MD, Olivier B. Utility of selective serotonin reuptake inhibitors in premature ejaculation. Curr Opin Investig Drugs 2004, 5:743-7.
13. Yilmaz U, Tatlisen A, Turan H, Arman F, Ekmekcioglu O. The effects of fluoxetine on several neurophysiological variables in patients with premature ejaculation. J Urol 1999, 34:15-8.
14. Kim SW, Paick JS. Peripheral effects of serotonin on the contractile responses of rat seminal vesicles and vasa deferentia. J Androl 2004, 25:893-9.
15. Seo KK, Kim SC, Lee MY. Comparison of peripheral inhibitory effects of clomipramine with selective serotonin re-uptake inhibitors on contraction of vas deferens: in vitro and in vivo studies. J Urol 2001, 165:2110-4.
16. Ückert S, Fuhlenriede MH, Becker AJ, Stief CG, Scheller F, Knapp WH, Forssmann WG, Jonas U. Is serotonin significant for the control of penile flaccidity and detumescence in the human male?. Urol Res 2003, 31:55-60.
17. Ückert S, Ehlers V, Nüser V, Oelke M, Kauffels W, Scheller F, Jonas U. In vitro functional responses of isolated human vaginal tissue to selective phospho-diesterase inhibitors. World J Urol 2005, 23:398-404.
18. Goldmeier D. 5-HT1A receptors on oxytocin neurons and premature ejaculation-A comment. J Sex Med 2007, 4:151.
19. Rehman J, Kaynan A, Christ G, Valcic M, Maayani S, Melman A. Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor. Brain Res 1999, 821:414-25.
20. Lau DH, Thompson CS, Bellringer JF, Mumtaz FH, Morgan RJ, Mikhailidis DP. Doxazosin and serotonin (5-HT) receptor (1A, 2A, and 4) antagonists inhibit 5-HT-mediated human cavernosal contraction. J Androl 2006, 27:679-85.
21. Berendsen HH, Broekkamp CL. Drug-induced penile erections in rats: Indications of serotonin 1B receptor mediation. Eur J Pharmacol 1987, 135:279-87.
22. Bancila M, Vergé D, Rampin O, Backstrom JR, Sanders-Bush E, McKenna KE, Marson L, Calas A, Giuliano F. 5-hydroxytryptamine 2C receptors on spinal neurons controlling penile erection in the rat. Neuroscience 1999, 92:1523-37.
23. Gruetter CA, Lemke SM, Anestis DK, Szarek JL, Valentovic MA. Potentiation of 5-hydroxytryptamine-induced contraction in rat aorta by chlorpheniramine, citalopram and fluoxetine. Eur J Pharmacol 1992, 217:109-18.
24. van Houtte PM, Cohen RA, van Nueten JM. Serotonin and arterial vessels. J Cardiovasc Pharmacol 1984, 6:S421-8.
25. Hsieh JT, Chang HC, Law HS, Hsieh CH, Cheng JT. In vivo evaluation of serotonergic agents and alpha adrenergic blockers on premature ejaculation by inhibiting the seminal vesicles pressure response to electrical nerve stimulation. Br J Urol 1998, 82:237-40.
26. Becker B, Morel N, van Bellinghen AM, Lebrun P. Blockade of calcium entry in smooth muscle cells by the antidepressant imipramine. Biochem Pharmacol 2004, 68:833-42.
27. Edgar VA, Sterin-Borda L, Cremaschi GA, Genaro AM, Chetty N, Desmond PV, Pouton CW, Coupar IM. Role of protein kinase C and cAMP in fluoxetine effects on human T-cell proliferation. Eur J Pharmacol 1999, 372:65-73.
28. Xia Z, dePierre JW, Nässberger L. Tricyclic antidepressants inhibit IL-6, IL-1 beta and TNF-alpha release in human blood monocytes and IL-2 and interferon-gamma in T cells. Immunopharmacology 1996, 34:27-37.
29. Irving HR, Tan YY, Tochon-Danguy N, Liu H, Chetty N, Desmond PV, Pouton CW, Coupar IM. Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life Sci 2007, 80:1198-205.
30. Ruat M, Traiffort E, Arrang JM, Tardivel-Lacombe J, Diaz J, Leurs R, Schwartz JC. A novel rat serotonin (5-HT6) receptor: Molecular cloning, localization and stimulation of cAMP accumulation. Biochem Biophys Res Commun 1993, 193:268-76.
31. Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR. Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. J Biol Chem 1998, 273:17469-76.
32. Nicholson CD, Challiss RA, Shahid M. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol Sci 1991, 12:19-27.