Role of protein kinase C and cAMP in fluoxetine effects on human T-cell proliferation

European Journal of Pharmacology

Volumn 372, Issue 1, 1999, Pages 65-73

  Ayelli Edgar, Valeria ^a   Sterin Borda, Leonor ^a   Cremaschi, Graciela A ^a   Genaro, Ana M ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Ca2+; cAMP; Fluoxetine; Immune response; Protein kinase C; T cell proliferation

Indexed keywords

CALCIMYCIN; CALCIUM ION; CONCANAVALIN A; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FLUOXETINE; MITOGENIC AGENT; PHORBOL 12 ACETATE 13 MYRISTATE; PROTEIN KINASE C; STAUROSPORINE;

ADULT; ARTICLE; CELL SUSPENSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CALCIMYCIN; CALCIUM; CELL DIVISION; CONCANAVALIN A; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; FLUOXETINE; HUMANS; IONOPHORES; PROTEIN KINASE C; T-LYMPHOCYTES;

EID: 0032940587     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00142-9     Document Type: Article

References (42)

1. Altman A., Coggeshall K.M., Mustelin T. Molecular events mediating T-cell activation. Adv. Immunol. 48:1990;227-360.
2. Anderson J., Möller G., Sjöberg O. Selective induction of DNA synthesis in T and B lymphocytes. Cell Immunol. 4:1972;381-393.
3. Ayelli Edgar V., Cremaschi G.A., Genaro A.M., Sterin-Borda L. Efecto inmunomodulador de la fluoxetina sobre la actividad proliferativa de linfocitos T murinos. Medicina. 56:1996;627.
4. Baldessarini, R.J., 1996. Drugs and treatment of psychiatric disorders. In: Hardman, J.G., Limbard, L.E., Goodman Gilman, A. (Eds.), The Pharmacological Basis of Therapeutics, 9th edn. McGraw-Hill, pp. 459-490.
5. Beavo J.A., Rogers N.L., Crofford O.B., Hardman J.G., Sutherland E.W., Newman E.V. Effects of xantine derivates on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity. Mol. Pharmacol. 6:1970;597-603.
6. Beckner K., Farrar W.L. Interleukin 2 modulation of adenylate cyclase. Potential role of protein kinase C. J. Biol. Chem. 261:1986;3043-3047.
7. Berkeley M.B., Daussin S., Hernandez M.C., Bayer B.M. In vitro effects of cocaine, lidocaine and monoamine uptake inhibitors on lymphocyte proliferative responses. Immunopharmacol. Immunotoxicol. 16:1994;165-178.
8. Berry N., Ase K., Kishimoto A., Nishizuka Y. Activation of resting human T cells requires prolonged stimulation of protein kinase C. Proc. Natl. Acad. Sci. U.S.A. 87:1990;2294-2298.
9. Brown B.L., Albano J.D., Ekins R.P., Gherzi A.M. A simple and sensitive saturation assay method for the measurement of adenosine 3′5′-cyclic monophosphate. Biochem. J. 121:1971;561-562.
10. Cazaux C.A., Sterin-Borda L., Gorelik G., Cremaschi G.A. Down-regulation of β-adrenergic receptor induced by mitogen activation of intracellular signalling events in lymphocytes. FEBS Lett. 364:1995;120-124.
11. Coffey R.G., Hadden J.W. Neurotransmitters, hormones and cyclic nucleotides in lymphocyte regulation. Fed. Proc. 44:1985;112-117.
12. Crowson A.N., Magro C.M. Antidepressant therapy: a possible cause of atypical cutaneous lymphoid hyperplasia. Arch. Dermatol. 131:1995;925-929.
13. Diaz-Guerra M.J.M., Bosca L. Lack of translocation of protein kinase C from the cytosol to the membrane in vasopresin-stimulated hepatocytes. Biochem. J. 269:1990;163-176.
14. 3H ]-dopamine uptake by human lymphocytes: correlates with serotonin transporter activity Pharmacology. 48:1994;320-327.
15. Faraj B.A., Olkowski Z.L., Jackson R.T. Expression of a high-affinity serotonin transporter in human lymphocytes. Int. J. Immunopharmacol. 16:1994;561-567.
16. + exchange and phopholipid turnover. Immunol. Rev. 95:1987;59-87.
17. Genaro A.M., Bosca L. Early signals in alloantigen-induced β-cell proliferation. J. Immunol. 151:1993;1832-1843.
18. 2+ mobilization in platelets. Eur. J. Pharmacol. 288:1995;373-377.
19. Irwin, M., 1995. Psychoneuroimmunology of depression. In: Bloom, F.E., Kupfer, D.J. (Eds.), Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, NY, pp. 983-988.
20. Isakov N., Mally M.I., Altman A. Mitogen-induced human T cell proliferation is associated with increased expression of selected PKC genes. Mol. Immunol. 29:1992;927-933.
21. Jasuda I., Kishimoto A., Tanaka S., Masahiro T., Sokurai A., Nishizuka A. Synthetic peptide substrate for selective assay of protein kinase C. Biochem. Biophys. Res. Commun. 166:1990;1220-1227.
22. Julius M.H., Simpson E., Herzenberg L.A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:1973;645-652.
23. Junco M., Diaz-Guerra M.J.M., Bosca L. Substrate-dependent inhibitors of protein kinase C by specific inhibitors. FEBS Lett. 263:1990;169-174.
24. Kaibuchi K., Takai Y., Nishizuka Y. Protein kinase C and Calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes. J. Biol. Chem. 260:1995;1366-1369.
25. Kaplan, H.I., Saddock, B.J., Grebb, J.A., 1994. Biological therapies. In: Kaplan, H.I., Saddock, B.J., Grebb, J.A. (Eds.), Synopsis of Psychiatry. Williams and Wilkins, Baltimore, MD, pp. 976-995.
26. Kelleher D.J., Pessin J.E., Ruoho A.E., Johnson G.L. Phorbol esters induces desensitization of adenylate cyclase and phosphorilation of the beta-adrenergic receptor in turkey erythrocytes. Proc. Natl. Acad. Sci. U.S.A. 81:1984;4316-4320.
27. Kelly M.W., Perry P.J., Holstad S.G., Garvey M.J. Serum fluoxetine and norfluoxetine concentration and antidepressant response. Ther. Drug Monit. 11:1989;165-170.
28. Kiecolt-Glaser J.K., Fisher L.D., Ogrocki P., Stout J.C., Speicher C.E., Glaser R. Marital quality, marital disruption and immune function. Psychosom. Med. 49:1987;13-34.
29. Kim D., Lancki D.W., Hui F.H., Fitch F.W. Protein kinase C-dependent and -independent mechanisms of cloned murine T cell proliferation. The role of protein kinase C translocation and protein kinase C activity. J. Immunol. 142:1989;616-622.
30. Ledbetter J.A., June C.H., Martin P.J., Spooner C.E., Hansen J.A., Meier K.E. Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects of protein kinase C, cytoplasmic free calcium, and proliferation. J. Immunol. 136:1986;3945-3952.
31. Levy E.M., Borrelli D.J., Mirin S.M., Salt P., Knapp P.H., Pierce C., Fox B.H., Black P.H. Biological measures and cellular immunological function in depressed psychiatric inpatients. Psychiat. Res. 36:1991;157-167.
32. McDaniel J.C. Psychoimmunology: implications for future research. South. Med. J. 85:1992;388-396.
33. Mills G.B., Lee J.W., Cheung R.K., Gelfand E.W. Characterization of the requirements for human T cell mitogenesis by using suboptimal concentrations of phytohemagglutinin. J. Immunol. 135:1985;3087-3093.
34. Orsulak P.J., Kenney J.T., Debus J.R., Crowley G., Whittman P.D. Determination of the antidepressant fluoxetine and its metabolite norfluoxetine in serum by reversed phase HPLC with ultraviolet detection. Clin. Chem. 34:1988;1875-1878.
35. 2+ and purified isozymes in washed permeabilized cells. J. Biol. Chem. 268:1993;1749-1756.
36. Rebois R.V., Patel J. Phorbol esters causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line. J. Biol. Chem. 260:1985;8026-8031.
37. Schachtele C., Seifert R., Osswald H. Stimulus-dependent inhibition of platelet aggregation by protein kinase C inhibitor polymyxin B, H-7 and staurosporine. Biochem. Biophys. Res. Commun. 155:1988;542-547.
38. Schmidt M.J., Fuller R.W., Wong D.T. Fluoxetine, a highly selective serotonin reuptake inhibitor: a review of pre-clinical studies. Br. J. Psychiat. 153:1988;40-46.
39. Stein M., Miller A.H., Trestman R.L. Depression and the immune system. Arch. Gen. Psychiat. 48:1991;171-177.
40. Valette L., Prigent A.F., Nemoz G., Anker G., Macovski O., Lagarde M. Concanavalin A stimulates the Rolipram-sensitive isoforms of cyclic nucleotide phosphodiesterase in rat thymic lymphocytes. Biochem. Biophys. Res. Commun. 169:1990;864-872.
41. Werner, H., Paegelow, I., Meyer-Rienecker, H., Bienert, M., 1987. Interactions between lymphocytes and neurotransmitters. Ann. New York Acad. Sci., 496-501.
42. Young S., Parker P.J., Ullrich A., Stabel S. Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem. J. 244:1987;775-779.