메뉴 건너뛰기




Volumn 6, Issue 10, 2009, Pages 2680-2689

Phosphodiesterase type 5 inhibitors facilitate noncontact erections in male rats: Site of action in the brain and mechanism of action

Author keywords

Dopamine; Nitric oxide; Noncontact erections; PDE5; Sexual arousal; Ventral tegmental area

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; TADALAFIL; VARDENAFIL; CARBOLINE DERIVATIVE; CYCLIC GMP; DOPAMINE; IMIDAZOLE DERIVATIVE; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE; TRIAZINE DERIVATIVE;

EID: 70649101493     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01410.x     Document Type: Article
Times cited : (25)

References (41)
  • 4
    • 33847384579 scopus 로고    scopus 로고
    • Early sildenafil dose optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction
    • Steidle CP, McCullough AR, Kaminetsky JC, Crowley AR, Siegel RL, Deriesthal H, Tseng LJ. Early sildenafil dose optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction. Int J Impot Res 2007, 19:154-60.
    • (2007) Int J Impot Res , vol.19 , pp. 154-160
    • Steidle, C.P.1    McCullough, A.R.2    Kaminetsky, J.C.3    Crowley, A.R.4    Siegel, R.L.5    Deriesthal, H.6    Tseng, L.J.7
  • 5
    • 0036193045 scopus 로고    scopus 로고
    • Apomorphine SL (Uprima®): Preclinical and clinical experiences learned from the first central nervous system-acting ED drug
    • Giuliano F, Allard J. Apomorphine SL (Uprima®): Preclinical and clinical experiences learned from the first central nervous system-acting ED drug. Int J Impot Res 2002, 14:S53-6.
    • (2002) Int J Impot Res , vol.14
    • Giuliano, F.1    Allard, J.2
  • 6
    • 0342549205 scopus 로고
    • Pharmacological analysis of the male sexual behavior
    • Bitran D, Hull EM. Pharmacological analysis of the male sexual behavior. Neurosci Biobehav Rev 1987, 11:365-89.
    • (1987) Neurosci Biobehav Rev , vol.11 , pp. 365-389
    • Bitran, D.1    Hull, E.M.2
  • 8
    • 0037083695 scopus 로고    scopus 로고
    • Influence of sildenafil on central dopamine-mediated behaviour in male rats
    • Ferrari F, Ottani A, Giuliani D. Influence of sildenafil on central dopamine-mediated behaviour in male rats. Life Sci 2002, 70:1501-8.
    • (2002) Life Sci , vol.70 , pp. 1501-1508
    • Ferrari, F.1    Ottani, A.2    Giuliani, D.3
  • 9
    • 0036227393 scopus 로고    scopus 로고
    • Influence of sildenafil on copulatory behaviour in sluggish or normal ejaculator male rats: A central dopamine mediated effect?
    • Giuliani D, Ottani A, Ferrari F. Influence of sildenafil on copulatory behaviour in sluggish or normal ejaculator male rats: A central dopamine mediated effect?. Neuropharmacology 2002, 42:562-7.
    • (2002) Neuropharmacology , vol.42 , pp. 562-567
    • Giuliani, D.1    Ottani, A.2    Ferrari, F.3
  • 10
    • 0036011317 scopus 로고    scopus 로고
    • Modulatory activity of sildenafil on copulatory behaviour of both intact and castrated male rats
    • Ottani A, Giuliani D, Ferrari F. Modulatory activity of sildenafil on copulatory behaviour of both intact and castrated male rats. Pharmacol Biochem Behav 2002, 72:717-22.
    • (2002) Pharmacol Biochem Behav , vol.72 , pp. 717-722
    • Ottani, A.1    Giuliani, D.2    Ferrari, F.3
  • 11
    • 51349119283 scopus 로고    scopus 로고
    • Sildenafil and a compound stimulating endothelial NO synthase modify sexual incentive motivation and copulatory behavior in male Wistar and Fisher 344 rats
    • Xi Chu, Zhavbert ES, Dugina JL, Kheyfets IA, Sergeeva SA, Epstein OI, Ågmo A. Sildenafil and a compound stimulating endothelial NO synthase modify sexual incentive motivation and copulatory behavior in male Wistar and Fisher 344 rats. J Sex Med 2008, 5:2085-99.
    • (2008) J Sex Med , vol.5 , pp. 2085-2099
    • Xi, C.1    Zhavbert, E.S.2    Dugina, J.L.3    Kheyfets, I.A.4    Sergeeva, S.A.5    Epstein, O.I.6    Ågmo, A.7
  • 12
    • 0032876253 scopus 로고    scopus 로고
    • The effect of sildenafil on apomorphine-evoked increases in intracavernous pressure in the awake rat
    • Andersson KE, Gemalmaz H, Waldek K, Chapman TN, Tuttle JB, Steers WD. The effect of sildenafil on apomorphine-evoked increases in intracavernous pressure in the awake rat. J Urol 1999, 161:1707-12.
    • (1999) J Urol , vol.161 , pp. 1707-1712
    • Andersson, K.E.1    Gemalmaz, H.2    Waldek, K.3    Chapman, T.N.4    Tuttle, J.B.5    Steers, W.D.6
  • 13
    • 0028865131 scopus 로고
    • Extracellular dopamine in the medial preoptic area: Implications for sexual motivation and hormonal control of copulation
    • Hull EM, Du J, Lorrain DS, Matuszewich L. Extracellular dopamine in the medial preoptic area: Implications for sexual motivation and hormonal control of copulation. J Neurosci 1995, 15:7465-71.
    • (1995) J Neurosci , vol.15 , pp. 7465-7471
    • Hull, E.M.1    Du, J.2    Lorrain, D.S.3    Matuszewich, L.4
  • 14
    • 26944456958 scopus 로고    scopus 로고
    • Dopamine, the medial preoptic area, and male sexual behavior
    • Dominguez JM, Hull EM. Dopamine, the medial preoptic area, and male sexual behavior. Physiol Behav 2005, 86:356-68.
    • (2005) Physiol Behav , vol.86 , pp. 356-368
    • Dominguez, J.M.1    Hull, E.M.2
  • 15
    • 33846879393 scopus 로고    scopus 로고
    • Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extracellular dopamine in the nucleus accumbens: Involvement of central oxytocin
    • Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR. Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extracellular dopamine in the nucleus accumbens: Involvement of central oxytocin. Neuropharmacology 2007, 52:1034-43.
    • (2007) Neuropharmacology , vol.52 , pp. 1034-1043
    • Succu, S.1    Sanna, F.2    Melis, T.3    Boi, A.4    Argiolas, A.5    Melis, M.R.6
  • 16
    • 21644439058 scopus 로고    scopus 로고
    • Male erectile dysfunction: Chemical pharmacology of penile erection
    • Argiolas A. Male erectile dysfunction: Chemical pharmacology of penile erection. Drug Discov Today Ther Strateg 2005, 2:31-6.
    • (2005) Drug Discov Today Ther Strateg , vol.2 , pp. 31-36
    • Argiolas, A.1
  • 17
    • 22744447482 scopus 로고    scopus 로고
    • Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus
    • Argiolas A, Melis MR. Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol 2005, 76:1-21.
    • (2005) Prog Neurobiol , vol.76 , pp. 1-21
    • Argiolas, A.1    Melis, M.R.2
  • 19
    • 0024242712 scopus 로고
    • Mesocortico-limbic dopamine system and reward
    • Fibiger HC, Phillips AG. Mesocortico-limbic dopamine system and reward. Ann N Y Acad Sci 1988, 537:206-15.
    • (1988) Ann N Y Acad Sci , vol.537 , pp. 206-215
    • Fibiger, H.C.1    Phillips, A.G.2
  • 20
    • 0025332085 scopus 로고
    • Sexual motivation: A neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses in male rats
    • Everitt BJ. Sexual motivation: A neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses in male rats. Neurosci Biobehav Rev 1990, 14:217-32.
    • (1990) Neurosci Biobehav Rev , vol.14 , pp. 217-232
    • Everitt, B.J.1
  • 22
    • 34547988176 scopus 로고    scopus 로고
    • Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats
    • Melis MR, Melis T, Cocco C, Succu S, Sanna F, Pillolla G, Boi A, Ferri GL, Argiolas A. Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats. Eur J Neurosci 2007, 26:1026-35.
    • (2007) Eur J Neurosci , vol.26 , pp. 1026-1035
    • Melis, M.R.1    Melis, T.2    Cocco, C.3    Succu, S.4    Sanna, F.5    Pillolla, G.6    Boi, A.7    Ferri, G.L.8    Argiolas, A.9
  • 23
    • 49249102931 scopus 로고    scopus 로고
    • Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: Role of nitric oxide and cyclic GMP
    • Succu S, Sanna F, Cocco C, Melis T, Boi A, Ferri GL, Argiolas A, Melis MR. Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: Role of nitric oxide and cyclic GMP. Eur J Neurosci 2008, 28:813-21.
    • (2008) Eur J Neurosci , vol.28 , pp. 813-821
    • Succu, S.1    Sanna, F.2    Cocco, C.3    Melis, T.4    Boi, A.5    Ferri, G.L.6    Argiolas, A.7    Melis, M.R.8
  • 24
    • 0031816904 scopus 로고    scopus 로고
    • Nitric oxide is increased in the paraventricular nucleus of male rats during non-contact erections and copulation
    • Melis MR, Succu S, Mauri A, Argiolas A. Nitric oxide is increased in the paraventricular nucleus of male rats during non-contact erections and copulation. Eur J Neurosci 1998, 10:1968-74.
    • (1998) Eur J Neurosci , vol.10 , pp. 1968-1974
    • Melis, M.R.1    Succu, S.2    Mauri, A.3    Argiolas, A.4
  • 25
    • 0030863279 scopus 로고    scopus 로고
    • Erection evoked in male rats by airborne scent from estrous females
    • Sachs BD. Erection evoked in male rats by airborne scent from estrous females. Physiol Behav 1997, 62:921-4.
    • (1997) Physiol Behav , vol.62 , pp. 921-924
    • Sachs, B.D.1
  • 26
  • 27
    • 0034130956 scopus 로고    scopus 로고
    • Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal
    • Sachs BD. Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal. Neurosci Biobehav Rev 2000, 24:541-60.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 541-560
    • Sachs, B.D.1
  • 28
    • 3042741857 scopus 로고    scopus 로고
    • What can animal models tell us about human sexual response?
    • Pfaus JG, Kippin TE, Coria-Avila G. What can animal models tell us about human sexual response?. Annu Rev Sex Res 2003, 14:1-63.
    • (2003) Annu Rev Sex Res , vol.14 , pp. 1-63
    • Pfaus, J.G.1    Kippin, T.E.2    Coria-Avila, G.3
  • 29
    • 34248676281 scopus 로고    scopus 로고
    • A contextual definition of male sexual arousal
    • Sachs BD. A contextual definition of male sexual arousal. Horm Behav 2007, 51:569-78.
    • (2007) Horm Behav , vol.51 , pp. 569-578
    • Sachs, B.D.1
  • 31
    • 0342980256 scopus 로고    scopus 로고
    • Sensory requirements for noncontact penile erection in the rat
    • Kondo Y, Tomihara K, Sakuma Y. Sensory requirements for noncontact penile erection in the rat. Behav Neurosci 1999, 113:1062-70.
    • (1999) Behav Neurosci , vol.113 , pp. 1062-1070
    • Kondo, Y.1    Tomihara, K.2    Sakuma, Y.3
  • 32
    • 0032969142 scopus 로고    scopus 로고
    • Morphine injected into the paraventricular nucleus of the hypothalamus prevents non-contact erections and impairs copulation: Role of nitric oxide
    • Melis MR, Succu S, Spano MS, Argiolas A. Morphine injected into the paraventricular nucleus of the hypothalamus prevents non-contact erections and impairs copulation: Role of nitric oxide. Eur J Neurosci 1999, 11:1857-64.
    • (1999) Eur J Neurosci , vol.11 , pp. 1857-1864
    • Melis, M.R.1    Succu, S.2    Spano, M.S.3    Argiolas, A.4
  • 33
    • 0037362074 scopus 로고    scopus 로고
    • Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activity
    • Melis MR, Succu S, Mascia MS, Cortis L, Argiolas A. Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activity. Eur J Neurosci 1999, 17:1266-72.
    • (1999) Eur J Neurosci , vol.17 , pp. 1266-1272
    • Melis, M.R.1    Succu, S.2    Mascia, M.S.3    Cortis, L.4    Argiolas, A.5
  • 34
    • 0032101180 scopus 로고    scopus 로고
    • Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens
    • Liu Y-C, Sachs BD, Salomone JD. Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacol Biochem Behav 1998, 60:585-92.
    • (1998) Pharmacol Biochem Behav , vol.60 , pp. 585-592
    • Liu, Y.-.C.1    Sachs, B.D.2    Salomone, J.D.3
  • 35
    • 22544464049 scopus 로고    scopus 로고
    • Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
    • Goto Y, Grace AA. Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior. Nat Neurosci 2005, 8:805-12.
    • (2005) Nat Neurosci , vol.8 , pp. 805-812
    • Goto, Y.1    Grace, A.A.2
  • 37
    • 61749093429 scopus 로고    scopus 로고
    • Phosphodiesterases in the central nervous system
    • Kleppisch T. Phosphodiesterases in the central nervous system. Handb Exp Pharmacol 2009, 191:71-92.
    • (2009) Handb Exp Pharmacol , vol.191 , pp. 71-92
    • Kleppisch, T.1
  • 39
    • 33947122201 scopus 로고    scopus 로고
    • Effect of the destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes
    • Gravitt K, Marson L. Effect of the destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes. J Sex Med 2007, 4:322-31.
    • (2007) J Sex Med , vol.4 , pp. 322-331
    • Gravitt, K.1    Marson, L.2
  • 40
    • 37549018468 scopus 로고    scopus 로고
    • Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors
    • Csoka A, Bahrick A, Mehtonen OP. Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. J Sex Med 2008, 5:227-33.
    • (2008) J Sex Med , vol.5 , pp. 227-233
    • Csoka, A.1    Bahrick, A.2    Mehtonen, O.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.