Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors

Journal of Sexual Medicine

Volumn 5, Issue 1, 2008, Pages 227-233

  Csoka, Antonei ^a   Bahrick, Audrey ^b   Mehtonen, Olli Pekka ^c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c Kaivanto Psychiatric Hospital Psychiatry   (Finland)

Author keywords

Erectile dysfunction; Iatrogenesis; Libido; Persistent; Sexual dysfunction; SSRI

Indexed keywords

AMFEBUTAMONE; CABERGOLINE; CITALOPRAM; DOPAMINE RECEPTOR STIMULATING AGENT; FLUOXETINE; METHYLPHENIDATE; MILNACIPRAN; PAROXETINE; PRAMIPEXOLE; PROSTAGLANDIN E1; ROPINIROLE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SILDENAFIL; VENLAFAXINE;

ADULT; ANHEDONIA; ANORGASMIA; ANXIETY DISORDER; ARTICLE; CASE REPORT; DRUG DOSE SEQUENCE; DRUG EFFICACY; DRUG FORMULATION; DRUG WITHDRAWAL; EJACULATION DISORDER; ERECTILE DYSFUNCTION; HUMAN; LIBIDO DISORDER; MAJOR DEPRESSION; MALE; MALE SEXUAL DYSFUNCTION; MEMORY DISORDER; ORGASM DISORDER; PATIENT COUNSELING; PRIORITY JOURNAL; SENSORY DYSFUNCTION; SEXUAL SATISFACTION; SIDE EFFECT; SOMNOLENCE; WEIGHT REDUCTION;

EID: 37549018468     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2007.00630.x     Document Type: Article

References (29)

1. Balon R. SSRI-associated sexual dysfunction. Am J Psychiatry 2006;163:1504-9.
2. Clayton A, Keller A, McGarvey EL. Burden of phase-specific sexual dysfunction with SSRIs. J Affect Disord 2006;91:27-32.
3. Csoka AB, Shipko S. Persistent sexual side effects after SSRI discontinuation. Psychother Psychosom 2006;75:187-8.
4. Bolton JM, Sareen J, Reiss JP. Genital anaesthesia persisting six years after sertraline discontinuation. J Sex Marital Ther 2006;32:327-30.
5. Adson DE, Kotlyar M. Premature ejaculation associated with citalopram withdrawal. Ann Pharmacother 2003;37:1804-6.
6. Goldmeier D, Leiblum SR. Persistent genital arousal in women-a new syndrome entity. Int J STD AIDS 2006;17:215-6.
7. Hines RN, Adams J, Buck GM, Faber W, Holson JF, Jacobson SW, Keszler M, McMartin K, Segraves RT, Singer LT, Sipes IG, Williams PL. Toxicology Program-Center for the Evaluation of Risks to Human Reproduction (CERHR) Expert panel report on the reproductive and developmental toxicity of fluoxetine. NIH Publication No. 05-4471. 2004: 1-211. Available at http://cerhr.niehs.nih.gov/chemicals/fluoxetine/fluoxetine_monograph.pdf (accessed June, 14, 2007).
8. Tanrikut C, Schlegel PN. Antidepressant-associated changes in semen parameters. Urology 2007;69:185.e5-7.
9. Keltner NL, McAfee KM, Taylor CL. Mechanisms and treatments of SSRI-induced sexual dysfunction. Perspect Psychiatr Care 2002;38:111-6.
10. Rosen RC, Lane RM, Menza M. Effects of SSRIs on sexual function: A critical review. J Clin Psychopharmacol 1999;19:67-85.
11. de Jong TR, Veening JG, Olivier B, Waldinger MD. Oxytocin involvement in SSRI-induced delayed ejaculation: A review of animal studies. J Sex Med 2007;4:14-28.
12. Cohen AJ. Antidepressant-induced sexual dysfunction associated with low serum free testosterone. Psychiatry on-line. 2002. Available at http://www.mhsanctuary.com/rx/testos.htm (accessed June 14, 2007).
13. Damsa C, Bumb A, Bianchi-Demicheli F, Vidailhet P, Sterck R, Andreoli A, Beyenburg S. "Dopamine-dependent"side effects of selective serotonin reuptake inhibitors: A clinical review. J Clin Psychiatry 2004;65:1064-8.
14. Kim SW, Dysken MW. Potential antidopaminergic effects of serotonin reuptake inhibitors. J Clin Psychiatry 1991;52:42.
15. Zhou FM, Liang Y, Salas R, Zhang L, De Biasi M, Dani JA. Corelease of dopamine and serotonin from striatal dopamine terminals. Neuron 2005;46:65-74.
16. Frohlich PF, Meston CM. Evidence that serotonin affects female sexual functioning via peripheral mechanisms. Physiol Behav 2000;71:383-93.
17. Frohlich P, Meston CM. Fluoxetine-induced changes in tactile sensation and sexual functioning among clinically depressed women. J Sex Marital Ther 2005;31:113-28.
18. Leo RJ. Movement disorders associated with the serotonin selective reuptake inhibitors. J Clin Psychiatry 1996;57:449-54.
19. Green B. Persistent adverse neurological effects following SSRI discontinuation (PANES). Psychiatry on-line. 2000. Available at http://www.priory.com/psych/panes.htm (accessed June 14, 2007).
20. Szeszko PR, MacMillan S, McMeniman M, Lorch E, Madden R, Ivey J, Banerjee SP, Moore GJ, Rosenberg DR. Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: Preliminary findings. Neuropsychopharmacology 2004;29:826-32.
21. Baird AD, Wilson SJ, Bladin PF, Saling MM, Reutens DC. The amygdala and sexual drive: Insights from temporal lobe epilepsy surgery. Ann Neurol 2004;55:87-96.
22. Whitelaw NC, Whitelaw E. How lifetimes shape epigenotype within and across generations. Hum Mol Genet 2006;15:R131-7.
23. Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature 2007;447:433-40.
24. Palotas M, Palotas A, Puskas LG, Kitajka K, Pakaski M, Janka Z, Molnar J, Penke B, Kalman J. Gene expression profile analysis of the rat cortex following treatment with imipramine and citalopram. Int J Neuropsychopharmacol 2004;7:401-13.
25. Hyman SE. Even chromatin gets the blues. Nat Neurosci 2006;9:465-6.
26. Panzer C, Wise S, Fantini G, Kang D, Munarriz R, Guay A, Goldstein I. Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: A retrospective study in women with sexual dysfunction. J Sex Med 2006;3:104-13.
27. Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RC, Paul IA. Antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 2006;31:47-57.
28. de Jong TR, Snaphaan LJ, Pattij T, Veening JG, Waldinger MD, Cools AR, Olivier B. Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats. Eur Neuropsychopharmacol 2006;16:39-48.
29. Waldinger MD, Schweitzer DH, Olivier B. On-demand SSRI treatment of premature ejaculation: Pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Med 2005;2:121-31.