Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

Toxicon

Volumn 55, Issue 1, 2010, Pages 126-134

  Bláha, Luděk ^a,b   Babica, Pavel ^a,c,d   Hilscherová, Klára ^a,b   Upham, Brad L ^c,d  

^a INSTITUTE OF BOTANY   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cyanobacteria; Cylindrospermopsin; Gap junctional intercellular communication; Liver tumor promotion; Microcystin; Mitogen activated protein kinases

Indexed keywords

BACTERIAL TOXIN; BACTERIUM LIPOPOLYSACCHARIDE; BIOLOGICAL MARKER; CYLINDROSPERMOPSIN; MICROCYSTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; APHANIZOMENON; ARTICLE; BACTERIAL OVERGROWTH; BACTERIUM CULTURE; CELL COMMUNICATION; CHLAMYDOMONAS REINHARDTII; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYANOBACTERIUM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FISCHER 344 RAT; GAP JUNCTION; IN VITRO STUDY; KLEBSIELLA; KLEBSIELLA TERRIGENA; LIVER TUMOR; MICROCYSTIS AERUGINOSA; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES COMPARISON; TUMOR PROMOTION; WESTERN BLOTTING;

ANIMALS; APHANIZOMENON; CARCINOGENS; CELL COMMUNICATION; CELL LINE; COMPLEX MIXTURES; CYANOBACTERIA; CZECH REPUBLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FRESH WATER; GAP JUNCTIONS; MICROCYSTINS; MICROCYSTIS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; TIME FACTORS; URACIL;

APHANIZOMENON; APHANIZOMENON FLOS-AQUAE; BACTERIA (MICROORGANISMS); CHLAMYDOMONAS REINHARDTII; CHLOROPHYTA; CYANOBACTERIA; MICROCYSTIS AERUGINOSA; RAOULTELLA TERRIGENA; RATTUS;

EID: 70649100407     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.07.009     Document Type: Article

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