Inhibition of gap-junctional intercellular communication by environmentally occuring polycyclic aromatic hydrocarbons

Toxicological Sciences

Volumn 65, Issue 1, 2002, Pages 43-51

  Bláha, Luděk ^a,b   Kapplová, Petra ^a,b   Vondráček, Jan ^a,c   Upham, Brad ^d   Machala, Miroslav ^a  

^a VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Gap junctional intercellular communication (GJIC); In vitro; Nongenotoxic carcinogenicity; Polycyclic aromatic hydrocarbons (PAHs); Tumor promotion

Indexed keywords

BENZO[A]PYRENE; BENZO[K]FLUORANTHENE; CHRYSENE DERIVATIVE; FLUORANTHENE; PERYLENE; PHORBOL 13 ACETATE 12 MYRISTATE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRENE DERIVATIVE; TUMOR PROMOTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CELL COMMUNICATION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; GAP JUNCTION; GROWTH INHIBITION; IN VITRO STUDY; LIVER CELL; MOLECULAR WEIGHT; NONHUMAN; POLLUTANT; RAT; RISK ASSESSMENT; SAMPLING; TUMOR PROMOTION;

ANIMALS; CARCINOGENS; CELL COMMUNICATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; EPITHELIUM; GAP JUNCTIONS; LIVER; MOLECULAR STRUCTURE; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; TETRADECANOYLPHORBOL ACETATE; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ANIMALIA;

EID: 0036146203     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/65.1.43     Document Type: Article

References (53)

1. Definitive relationships among chemical structure, carcinogenity, and mutagenicity for 301 chemicals tested by the U.S. NTP
2. Overview of tumour promoters and test systems to identify promoters
3. Inhibition of gap junctional intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat hepatocytes
4. Ability of polycyclic aromatic hydrocarbons to induce 7-ethoxyresorufin-O-deethylase activity in a trout liver cell line
5. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: Implications for the alternative pathway of PAH activation catalyzed by dehydrogenase
6. Water-related environmental fate of 129 priority pollutants
7. Evidence of estrogen- and TCDD-like activities in crude and fractionated extracts of PM10 air particulate material, using in vitro gene expression assays
8. Toxic equivalency factor approach for risk assessment of polycyclic aromatic hydrocarbons
9. Human cell mutagenicity of oxygenated, nitrated, and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols
10. Mutagenicity of C24H14 PAH in human cells expressing cyp1A1
11. Scrape-loading and dye transfer. A rapid and simple technique to study gap-junctional intercellular communication
12. Tumor promotion: Models and assay systems
13. Tumour promotion-related effects by the cyclodiene insecticide endosulfan: Studies in vitro and in vivo
14. 2+ are not involved in DDT-induced loss of gap-junctional communication in WB-F344 cells
15. Epigenetic toxicity of a mixture of polycyclic aromatic hydrocarbons on gap junctional intercellular communication before and after biodegradation
16. IARC Monographs on the evaluation of the carcinogenic risk of chemicals in humans: I. Chemical, environmental, and experimental data
17. Relative potencies of PAHs and PCBs are based on the response of human cells
18. Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-O-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: The mitogen-activated protein kinase
19. Regulation of gap junctions by phosphorylation of connexins
20. The cell-cell channel of gap junctions
21. Pulse treatment with the tumor promoter TPA delays the onset of desensitization response and prolongs the inhibitory effect on gap-junctional intercellular communication of a rat liver epithelial cell line WB F-344
22. Induction effects of polychlorinated biphenyls, polycyclic aromatic hydrócarbons, and other widespread aromatic environmental pollutants on microsomal monooxygenase activities in chick embryo liver
23. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter-gene assay
24. Bioassay-directed fractionation of PAH of molecular mass 302 in coal tar-contaminated sediment
25. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
26. Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs)
27. The cytosolic receptor-binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons
28. Inhibition of gap junctional intercellular communication by tumor promoters in connexin43- and connexin32-expressing liver cells: Cell specificity and role of protein kinase C
29. Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena
30. Intercellular communication, tumor promotion, and nongenotoxic carcinogenesis: Relationships based upon structural considerations
31. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap-junctional intercellular communication and stimulated MAPK activity
32. Ah receptor agonists as endocrine disruptors: Antiestrogenic activity and mechanisms
33. Inhibitory effect of pentachlorophenol on gap junctional intercellular communication in liver epithelial cells in vitro
34. Assessment of the potential in vivo genotoxicity of fluoranthene
35. 2+ and proliferation in primary human mammary epithelial cells
36. Challenge to the simple paradigm that "carcinogens" are "mutagens" and to the in vitro and in vivo assays used to test the paradigm
37. Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication
38. Intercellular communication may facilitate apoptosis: Implications for tumor promotion
39. Cell-cell communication in carcinogenesis
40. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of "oval" cells
41. Inhibition of gap junction communication, activation of MAPK, and release of arachidonic acid by specific isomers of methylated anthracenes
42. Nongenotoxic effects of selected pesticides and their disinfection by-products on gap junctional intercellular communication
43. Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione-sufficient but not gluthathione-deficient cells
44. Nongenotoxic effects of polycyclic aromatic hydrocarbons and their oxygenation by-products on the intercellular communication of rat liver epithelial cells
45. Modulated gap-junctional intercellular communication as a biomarker of PAH epigenetic toxicity: Structure-function relationship
46. Toxic equivalency factors (TEFs) for PCBs, PCDDs, and PCDFs for humans and wildlife-A review
47. Induction of lung and liver tumors by fluoranthene in a preweaning CD-1 mouse bioassay
48. Inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) in culture by various DDT-analogs
49. Mechanistic studies on the DDT-induced inhibition of intercellular communication
50. Bay or bay-like regions of polycyclic aromatic hydrocarbons were potent inhibitors of gap junctional intercellular communication
51. Characterization of the H4IIE rat hepatoma-cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs)
52. Intercellular communication and carcinogenesis