Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 113, Issue 12, 2006, Pages 1412-1418

  Verkleij Hagoort, A C ^a   Verlinde, M ^a   Ursem, N T C ^a   Lindemans, J ^a   Helbing, W A ^a   Ottenkamp, J ^b   Siebel, F M H ^c   Gittenberger De Groot, A C ^b   De Jonge, R ^a   Bartelings, M M ^b   Steegers, E A P ^a   Steegers Theunissen, R P M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Thuiszorg Nieuwe Waterweg Noord   (Netherlands)

Author keywords

Congenital; Folic acid; Heart defects; Homocysteine; Risk; Vitamins

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; CHILD; CONGENITAL HEART DISEASE; CONTROLLED STUDY; DATA ANALYSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; PREGNANCY; PRESCHOOL CHILD; PRIORITY JOURNAL; RANK SUM TEST; RISK FACTOR; VENOUS BLOOD;

ADULT; CASE-CONTROL STUDIES; FEMALE; FOLIC ACID; HEART DISEASES; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INFANT; MATERNAL AGE; PREGNANCY; PREGNANCY COMPLICATIONS; RISK FACTORS; STATISTICS, NONPARAMETRIC; VITAMIN B 12;

EID: 33750930659     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2006.01109.x     Document Type: Article

References (25)

1. Department of Medical Genetics, University Medical Centre Groningen, Groningen, the Netherlands. European Registration Of Congenital Anomalies and Twins (EUROCAT). [www.eurocatnederland.nl]. Accessed 20 August 2005.
2. Botto LD, Correa A. Decreasing the burden of congenital heart anomalies: an epidemiologic evaluation of risk factors and survival. Prog Pediatr Cardiol 2003;18:111-21.
3. Loffredo CA. Epidemiology of cardiovascular malformations: prevalence and risk factors. Am J Med Genet 2000;97:319-25.
4. Botto LD, Mulinare J, Erickson JD. Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps. Am J Med Genet A 2003;121:95-101.
5. Shaw GM, O'Malley CD, Wasserman CR, Tolarova MM, Lammer EJ. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 1995;59:536-45.
6. Hernandez-Diaz S, Werler MM, Walker AM, Mitchell AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 2000;343:1608-14.
7. Perna AF, Ingrosso D, De Santo NG. Homocysteine and oxidative stress. Amino Acids 2003;25:409-17.
8. Boot MJ, Steegers-Theunissen RP, Poelmann RE, van Iperen L, Gittenberger-de Groot AC. Cardiac outflow tract malformations in chick embryos exposed to homocysteine. Cardiovasc Res 2004;64:365-73.
9. Boot MJ, Steegers-Theunissen RP, Poelmann RE, Van Iperen L, Lindemans J, Gittenberger-de Groot AC. Folic acid and homocysteine affect neural crest and neuroepithelial cell outgrowth and differentiation in vitro. Dev Dyn 2003;227:301-8.
10. McKay JA, Williams EA, Mathers JC. Folate and DNA methylation during in utero development and aging. Biochem Soc Trans 2004;32:1006-7.
11. Groenen PM, Peer PG, Wevers RA, Swinkels DW, Franke B, Mariman EC, et al. Maternal myo-inositol, glucose, and zinc status is associated with the risk of offspring with spina bifida. Am J Obstet Gynecol 2003;189:1713-19.
12. van Rooij IA, Swinkels DW, Blom HJ, Merkus HM, Steegers-Theunissen RP. Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. Am J Obstet Gynecol 2003;189:1155-60.
13. Willett W. Nature of variation in diet. In: Willett W, editor. Nutritional Epidemiology. 2nd edn. New York, NY: Oxford University Press; 1998. pp. 33-50.
14. Statistics Netherlands. Classification of educational level and ethnicity. Voorburg/Heerlen, the Netherlands. [www.cbs.nl/en-GB/menu/methoden/ methoden-per-thema/default.htm]. Accessed 15 October 2005.
15. de Jonge R, Griffioen PH, van Zelst B, Brouns RM, Visser W, Lindemans J. Evaluation of a shorter methionine loading test. Clin Chem Lab Med 2004;42:1027-31.
16. Kapusta L, Haagmans ML, Steegers EA, Cuypers MH, Blom HJ, Eskes TK. Congenital heart defects and maternal derangement of homocysteine metabolism. J Pediatr 1999;135:773-4.
17. Hobbs CA, Cleves MA, Melnyk S, Zhao W, James SJ. Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism. Am J Clin Nutr 2005;81:147-53.
18. Scheen AJ, Paquot N, Letiexhe MR, Paolisso G, Castillo MJ, Lefebvre PJ. Glucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies. Int J Obes Relat Metab Disord 1995;19(Suppl 3):S14-20.
19. Watkins ML, Botto LD. Maternal prepregnancy weight and congenital heart defects in offspring. Epidemiology 2001;12:439-46.
20. Cedergren MI, Kallen BA. Maternal obesity and infant heart defects. Obes Res 2003;11:1065-71.
21. Loffredo CA, Wilson PD, Ferencz C. Maternal diabetes: an independent risk factor for major cardiovascular malformations with increased mortality of affected infants. Teratology 2001;64:98-106.
22. Panagiotakos DB, Pitsavos C, Zeimbekis A, Chrysohoou C, Stefanadis C. The association between lifestyle-related factors and plasma homocysteine levels in healthy individuals from the "ATTICA" Study. Int J Cardiol 2005;98:471-7.
23. Devine CM, Bove CF, Olson CM. Continuity and change in women's weight orientations and lifestyle practices through pregnancy and the postpartum period: the influence of life course trajectories and transitional events. Soc Sci Med 2000;50:567-82.
24. Brouwer IA, van Dusseldorp M, Thomas CM, Duran M, Hautvast JG, Eskes TK, et al. Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J Clin Nutr 1999;69:99-104.
25. Cikot RJ, Steegers-Theunissen RP, Thomas CM, de Boo TM, Merkus HM, Steegers EA. Longitudinal vitamin and homocysteine levels in normal pregnancy. Br J Nutr 2001;85:49-58.