메뉴 건너뛰기




Volumn 3, Issue 4, 2009, Pages 353-361

Can nonalcoholic steatohepatitis be diagnosed without liver biopsy?

Author keywords

Adiponectin; Cytokeratin 18; Insulin resistance; Liver biopsy; NashTest ; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Noninvasive diagnosis; Steatosis

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CYTOKERATIN 18; HYALURONIC ACID; LEPTIN; M30 ANTIGEN; M65 ANTIGEN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 70549098304     PISSN: 17520363     EISSN: None     Source Type: Journal    
DOI: 10.2217/bmm.09.36     Document Type: Review
Times cited : (7)

References (65)
  • 1
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • Excellent review on insulin resistance and liver injury
    • Bugianesi E, McCullough AJ, Marchesini G: Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42, 987-1000 (2005). ■ Excellent review on insulin resistance and liver injury.
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 2
    • 0033200054 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions
    • Classic description of histological lesions in nonalcoholic fatty liver disease (NAFLD) and a widely accepted proposal for grading/staging
    • Brunt EM, Janney CG, DiBisceglie AM et al.: Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 94, 2467-2474 (1999). ■ Classic description of histological lesions in nonalcoholic fatty liver disease (NAFLD) and a widely accepted proposal for grading/staging.
    • (1999) Am. J. Gastroenterol. , vol.94 , pp. 2467-2474
    • Brunt, E.M.1    Janney, C.G.2    Dibisceglie, A.M.3
  • 3
    • 33750312195 scopus 로고    scopus 로고
    • Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease
    • DOI 10.1136/gut.2006.091454
    • Guha IN, Parkes J, Roderick PR et al.: Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease. Gut 55, 1650-1660 (2006). (Pubitemid 44629217)
    • (2006) Gut , vol.55 , Issue.11 , pp. 1650-1660
    • Guha, I.N.1    Parkes, J.2    Roderick, P.R.3    Harris, S.4    Rosenberg, W.M.5
  • 5
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study
    • Teli MR, James OFW, Burt D et al.: The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 22, 1714-1719 (1995).
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.W.2    Burt, D.3
  • 6
    • 0034116558 scopus 로고    scopus 로고
    • Liver fibrosis in overweight patients
    • Ratziu V, Giral P, Charlotte F et al.: Liver fibrosis in overweight patients. Gastroenterology 118, 1117-1123 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 1117-1123
    • Ratziu, V.1    Giral, P.2    Charlotte, F.3
  • 7
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • One of the first studies to demonstrate increased mortality and, specifically, liver-related mortality in nonalcoholic steatohepatitis (NASH) patients
    • Adams LA, Lymp JF, St Sauver J et al.: The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 129, 113-121 (2005). ■ One of the first studies to demonstrate increased mortality and, specifically, liver-related mortality in nonalcoholic steatohepatitis (NASH) patients.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 9
    • 20444443042 scopus 로고    scopus 로고
    • Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    • Ratziu V, Charlotte F, Heurtier A et al.: Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 128, 1898-1906 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 1898-1906
    • Ratziu, V.1    Charlotte, F.2    Heurtier, A.3
  • 12
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Important study confirming increased overall, liver-related and cardiovascular mortality
    • Ekstedt M, Franzen LE, Mathiesen UL et al.: Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 44, 865-873 (2006). ■ Important study confirming increased overall, liver-related and cardiovascular mortality.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 15
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS, O'Brien PE: Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 121, 91-100 (2001).
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 16
    • 46249084411 scopus 로고    scopus 로고
    • A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients
    • Campos GM, Bambha K, Vittinghoff E et al.: A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients. Hepatology 47, 1916-1923 (2008).
    • (2008) Hepatology , vol.47 , pp. 1916-1923
    • Campos, G.M.1    Bambha, K.2    Vittinghoff, E.3
  • 18
    • 0242443339 scopus 로고    scopus 로고
    • Prevalence and Predictors of Asymptomatic Liver Disease in Patients Undergoing Gastric Bypass Surgery
    • DOI 10.1001/archsurg.138.11.1240
    • Beymer C, Kowdley KV, Larson A et al.: Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass surgery. Arch. Surg. 138, 1240-1244 (2003). (Pubitemid 37392401)
    • (2003) Archives of Surgery , vol.138 , Issue.11 , pp. 1240-1244
    • Beymer, C.1    Kowdley, K.V.2    Larson, A.3    Edmonson, P.4    Dellinger, E.P.5    Flum, D.R.6
  • 19
    • 33645090537 scopus 로고    scopus 로고
    • Race and comorbid factors predict nonalcoholic fatty liver disease histopathology in severely obese patients
    • Solga SF, Clark JM, Alkhuraishi AR et al.: Race and comorbid factors predict nonalcoholic fatty liver disease histopathology in severely obese patients. Surg. Obes. Relat. Dis. 1, 6-11 (2005).
    • (2005) Surg. Obes. Relat. Dis. , vol.1 , pp. 6-11
    • Solga, S.F.1    Clark, J.M.2    Alkhuraishi, A.R.3
  • 21
    • 33644535823 scopus 로고    scopus 로고
    • Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery
    • DOI 10.1381/096089206775565122
    • Harnois F, Msika S, Sabate JM et al.: Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery. Obes. Surg. 16, 183-188 (2006). (Pubitemid 43302243)
    • (2006) Obesity Surgery , vol.16 , Issue.2 , pp. 183-188
    • Harnois, F.1    Msika, S.2    Sabate, J.-M.3    Mechler, C.4    Jouet, P.5    Barge, J.6    Coffin, B.7
  • 25
    • 33646853899 scopus 로고    scopus 로고
    • Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease
    • DOI 10.1111/j.1365-2265.2006.02527.x
    • Targher G, Bertolini L, Rodella S et al.: Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease. Clin. Endocrinol. (Oxf.) 64, 679-683 (2006). (Pubitemid 43775007)
    • (2006) Clinical Endocrinology , vol.64 , Issue.6 , pp. 679-683
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Zoppini, G.4    Scala, L.5    Zenari, L.6    Falezza, G.7
  • 27
    • 33646013904 scopus 로고    scopus 로고
    • Clinical model for distinguishing nonalcoholic steatohepatitis from simple steatosis in patients with nonalcoholic fatty liver disease
    • Palekar NA, Naus R, Larson SP et al.: Clinical model for distinguishing nonalcoholic steatohepatitis from simple steatosis in patients with nonalcoholic fatty liver disease. Liver Int. 26, 151-156 (2006).
    • (2006) Liver Int. , vol.26 , pp. 151-156
    • Palekar, N.A.1    Naus, R.2    Larson, S.P.3
  • 28
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • DOI 10.1172/JCI200317797
    • Xu A, Wang Y, Keshaw H et al.: The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 112, 91-100 (2003). ■ Experimental data in favor of a protective role for adiponectin in NAFLD. (Pubitemid 38056380)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.1 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.L.5    Cooper, G.J.S.6
  • 29
    • 34548532367 scopus 로고    scopus 로고
    • Serum adipokine levels predictive of liver injury in patients with non-alcoholic fatty liver disease
    • Lemoine M, Ratziu V, Maachi M et al.: Serum adipokine levels predictive of liver injury in patients with non-alcoholic fatty liver disease. J. Hepatol. 42, 24A (2005).
    • (2005) J. Hepatol. , vol.42
    • Lemoine, M.1    Ratziu, V.2    Maachi, M.3
  • 30
    • 33748184089 scopus 로고    scopus 로고
    • Metabolic and adipokine profile of Chinese patients with nonalcoholic fatty liver disease
    • Wong VW, Hui AY, Tsang SW et al.: Metabolic and adipokine profile of Chinese patients with nonalcoholic fatty liver disease. Clin. Gastroenterol. Hepatol. 4, 1154-1161 (2006).
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 1154-1161
    • Wong, V.W.1    Hui, A.Y.2    Tsang, S.W.3
  • 36
    • 33746703237 scopus 로고    scopus 로고
    • The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH
    • Anty R, Bekri S, Luciani N et al.: The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH. Am. J. Gastroenterol. 101, 1824-1833 (2006).
    • (2006) Am. J. Gastroenterol. , vol.101 , pp. 1824-1833
    • Anty, R.1    Bekri, S.2    Luciani, N.3
  • 37
    • 0036780582 scopus 로고    scopus 로고
    • Pathogenesis of steatohepatitis
    • Interesting review on the pathophysiology of NASH
    • Day CP: Pathogenesis of steatohepatitis. Best Pract. Res. Clin. Gastroenterol. 16, 663-678 (2002). ■ Interesting review on the pathophysiology of NASH.
    • (2002) Best Pract. Res. Clin. Gastroenterol. , vol.16 , pp. 663-678
    • Day, C.P.1
  • 38
    • 4444382031 scopus 로고    scopus 로고
    • Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis
    • DOI 10.1111/j.1572-0241.2004.30159.x
    • Chalasani N, Deeg MA, Crabb DW: Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis. Am. J. Gastroenterol. 99, 1497-1502 (2004). (Pubitemid 39193189)
    • (2004) American Journal of Gastroenterology , vol.99 , Issue.8 , pp. 1497-1502
    • Chalasani, N.1    Deeg, M.A.2    Crabb, D.W.3
  • 41
    • 37549069361 scopus 로고    scopus 로고
    • Blood oxidative stress markers in nonalcoholic steatohepatitis and how it correlates with diet
    • Machado MV, Ravasco P, Jesus L et al.: Blood oxidative stress markers in nonalcoholic steatohepatitis and how it correlates with diet. Scand. J. Gastroenterol. 43, 95-102 (2008).
    • (2008) Scand. J. Gastroenterol. , vol.43 , pp. 95-102
    • Machado, M.V.1    Ravasco, P.2    Jesus, L.3
  • 42
    • 58249104011 scopus 로고    scopus 로고
    • Plasma pentraxin 3 is a novel marker for nonalcoholic steatohepatitis (NASH)
    • Yoneda M, Uchiyama T, Kato S et al.: Plasma pentraxin 3 is a novel marker for nonalcoholic steatohepatitis (NASH). BMC Gastroenterol. 8, 53 (2008).
    • (2008) BMC Gastroenterol. , vol.8 , pp. 53
    • Yoneda, M.1    Uchiyama, T.2    Kato, S.3
  • 44
    • 34547539428 scopus 로고    scopus 로고
    • Usefulness of a combined evaluation of the serum adiponectin level, HOMA-IR, and serum type IV collagen 7S level to predict the early stage of nonalcoholic steatohepatitis
    • Shimada M, Kawahara H, Ozaki K et al.: Usefulness of a combined evaluation of the serum adiponectin level, HOMA-IR, and serum type IV collagen 7S level to predict the early stage of nonalcoholic steatohepatitis. Am. J. Gastroenterol. 102, 1931-1938 (2007).
    • (2007) Am. J. Gastroenterol. , vol.102 , pp. 1931-1938
    • Shimada, M.1    Kawahara, H.2    Ozaki, K.3
  • 45
    • 67349263467 scopus 로고    scopus 로고
    • Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease
    • Yilmaz Y, Ulukaya E, Gul OO et al.: Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease. Clin. Biochem. 42, 802-807 (2009).
    • (2009) Clin. Biochem. , vol.42 , pp. 802-807
    • Yilmaz, Y.1    Ulukaya, E.2    Gul, O.O.3
  • 47
    • 3242798959 scopus 로고    scopus 로고
    • Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C
    • Important aspect of a validation of any noninvasive method
    • Poynard T, Munteanu M, Imbert-Bismut F et al.: Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Clin. Chem. 50, 1344-1355 (2004). ■ Important aspect of a validation of any noninvasive method.
    • (2004) Clin. Chem. , vol.50 , pp. 1344-1355
    • Poynard, T.1    Munteanu, M.2    Imbert-Bismut, F.3
  • 48
    • 9644279531 scopus 로고    scopus 로고
    • Serum markers detect the presence of liver fibrosis: A cohort study
    • A promising marker of fibrosis in NASH
    • Rosenberg WM, Voelker M, Thiel R et al.: Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology 127, 1704-1713 (2004). ■ A promising marker of fibrosis in NASH.
    • (2004) Gastroenterology , vol.127 , pp. 1704-1713
    • Rosenberg, W.M.1    Voelker, M.2    Thiel, R.3
  • 50
    • 33845207096 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease
    • One of the few biomarkers designed and validated specifically for NASH
    • Poynard T, Ratziu V, Charlotte F et al.: Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 6, 34 (2006). ■ One of the few biomarkers designed and validated specifically for NASH.
    • (2006) BMC Gastroenterol. , vol.6 , pp. 34
    • Poynard, T.1    Ratziu, V.2    Charlotte, F.3
  • 51
    • 33748250671 scopus 로고    scopus 로고
    • Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study
    • A national, multicentric collaboration demonstrating that steatosis and steatohepatitis each account for a quarter of patients with unexplained alanine aminotransferase elevations
    • de Ledinghen V, Ratziu V, Causse X et al.: Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study. J. Hepatol. 45, 592-599 (2006). ■ A national, multicentric collaboration demonstrating that steatosis and steatohepatitis each account for a quarter of patients with unexplained alanine aminotransferase elevations.
    • (2006) J. Hepatol. , vol.45 , pp. 592-599
    • De Ledinghen, V.1    Ratziu, V.2    Causse, X.3
  • 52
  • 53
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
    • DOI 10.1016/S0016-5085(03)00907-7
    • Feldstein AE, Canbay A, Angulo P et al.: Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125, 437-443 (2003). ■ One of the first studies to demonstrate apoptosis in NASH. (Pubitemid 36929425)
    • (2003) Gastroenterology , vol.125 , Issue.2 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4    Burgart, L.J.5    Lindor, K.D.6    Gores, G.J.7
  • 54
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • A promising biomarker for NASH awaiting further validation
    • Wieckowska A, Zein NN, Yerian LM et al.: In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44, 27-33 (2006). ■ A promising biomarker for NASH awaiting further validation.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 55
    • 37749032395 scopus 로고    scopus 로고
    • Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers
    • author reply 2048
    • Mitry RR, De Bruyne R, Quaglia A et al.: Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers. Hepatology 46, 2047-2048; author reply 2048 (2007).
    • (2007) Hepatology , vol.46 , pp. 2047-2048
    • Mitry, R.R.1    De Bruyne, R.2    Quaglia, A.3
  • 57
    • 55149102644 scopus 로고    scopus 로고
    • Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients
    • Diab DL, Yerian L, Schauer P et al.: Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin. Gastroenterol. Hepatol. 6, 1249-1254 (2008).
    • (2008) Clin. Gastroenterol. Hepatol. , vol.6 , pp. 1249-1254
    • Diab, D.L.1    Yerian, L.2    Schauer, P.3
  • 58
    • 53849114643 scopus 로고    scopus 로고
    • A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH)
    • Younossi ZM, Jarrar M, Nugent C et al.: A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH). Obes. Surg. 18, 1430-1437 (2008).
    • (2008) Obes. Surg. , vol.18 , pp. 1430-1437
    • Younossi, Z.M.1    Jarrar, M.2    Nugent, C.3
  • 59
    • 33845592323 scopus 로고    scopus 로고
    • Serum concentrations of the tissue polypeptide specific antigen in patients suffering from non-alcoholic steatohepatitis
    • DOI 10.1111/j.1365-2362.2007.01745.x
    • Tarantino G, Conca P, Coppola A et al.: Serum concentrations of the tissue polypeptide specific antigen in patients suffering from non-alcoholic steatohepatitis. Eur. J. Clin. Invest. 37, 48-53 (2007). (Pubitemid 44934772)
    • (2007) European Journal of Clinical Investigation , vol.37 , Issue.1 , pp. 48-53
    • Tarantino, G.1    Conca, P.2    Coppola, A.3    Vecchione, R.4    Di Minno, G.5
  • 60
    • 25644448266 scopus 로고    scopus 로고
    • Fat in the liver and insulin resistance
    • Yki-Jarvinen H: Fat in the liver and insulin resistance. Ann. Med. 37, 347-356 (2005).
    • (2005) Ann. Med. , vol.37 , pp. 347-356
    • Yki-Jarvinen, H.1
  • 63
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal GP, Thomas JA, Kaye PV et al.: Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 135, 1176-1184 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3
  • 64
    • 66649083733 scopus 로고    scopus 로고
    • Serum proteomic profiling of obese patients: Correlation with liver pathology and evolution after bariatric surgery
    • Trak-Smayra V, Dargere D, Noun R et al.: Serum proteomic profiling of obese patients: correlation with liver pathology and evolution after bariatric surgery. Gut 58, 825-832 (2009).
    • (2009) Gut , vol.58 , pp. 825-832
    • Trak-Smayra, V.1    Dargere, D.2    Noun, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.