Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study

Journal of Hepatology

Volumn 45, Issue 4, 2006, Pages 592-599

  de Lédinghen, Victor ^a,b   Ratziu, Vlad ^c   Causse, Xavier ^d   Bail, Brigitte Le ^b,e   Capron, Dominique ^f   Renou, Christophe ^g   Pilette, Christophe ^g   Oules, Valérie ^h   Gelsi, Eve ⁱ   Oberti, Frédéric ^j   Vallet Pichard, Anaïs ^k   Provost, Nicolas Le ^a   Cadranel, Jean François ^g  

^a HAUT LÉVÊQUE HOSPITAL   (France)

^b INSERM   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d Centre Hospitalier Régional   (France)

^e HÔPITAL PELLEGRIN   (France)

^f AMIENS UNIVERSITY HOSPITAL   (France)

^g CENTRE HOSPITALIER   (France)

^h HÔPITAL SAINT JOSEPH   (France)

ⁱ UNIVERSITY HOSPITAL OF NICE   (France)

^j ANGERS UNIVERSITY HOSPITAL   (France)

^k HÔPITAL NECKER ENFANTS MALADES   (France)

more..

Author keywords

Chronic hepatitis; Cytolysis; Fibrosis; Liver biopsy; NASH; Steatosis; Transaminases

Indexed keywords

ALANINE AMINOTRANSFERASE; BIOLOGICAL FACTOR;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CLINICAL EXAMINATION; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; ECHOGRAPHY; FATTY LIVER; FEMALE; HUMAN; HUMAN TISSUE; INDEPENDENT VARIABLE; LIVER BIOPSY; LIVER EXAMINATION; LIVER FIBROSIS; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NONALCOHOLIC FATTY LIVER; PATHOLOGY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK; STATISTICAL SIGNIFICANCE; TOBACCO DEPENDENCE;

ADULT; ALANINE TRANSAMINASE; BIOPSY; FATTY LIVER; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 33748250671     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2006.05.008     Document Type: Article

References (28)

1. Ludwig J., Viggiano T.R., McGill D.B., and Ott B.J. Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55 (1980) 434-438
2. Kundrotas L.W., and Clément D.J. Serum alanine aminotransferase (ALT) elevation in asymptomatic US Air Force basic trainee blood donors. Dig Dis Sci 38 (1993) 2145-2150
3. Pratt D.S., and Kaplan M.M. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med 342 (2000) 1266-1271
4. Sorbi D., McGill D.B., Thistle J.L., Therneau T.M., Henry J., and Lindor K.D. An assessment of the role of liver biopsies in asymptomatic patients with chronic liver test abnormalities. Am J Gastroenterol 95 (2000) 3206-3210
5. Skelly M.M., James P.D., and Ryder S.D. Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology. J Hepatol 35 (2001) 195-199
6. Van Ness M.M., and Diehl A.M. Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes?. Ann Intern Med 111 (1989) 473-478
7. de Lédinghen V., Combes M., Trouette H., Winnock M., Amouretti M., de Mascarel A., et al. Should a liver biopsy be done in patients with subclinical chronically elevated transaminases?. Eur J Gastroenterol Hepatol 16 (2004) 879-883
8. Bray G.A. Classification and evaluation of the obesities. Med Clin North Am 73 (1989) 161-184
9. Bardella M.T., Vecchi M., Conte D., Del Ninno E., Fraquelli M., Pacchetti S., et al. Chronic unexplained hypertransaminasemia may be caused by occult celiac disease. Hepatology 29 (1999) 654-657
10. Boulton R., Hamilton M.I., Dhillon A.P., Kinloch J.D., and Burroughs A.K. Subclinical Addison's disease: a cause of persistent abnormalities in aminotransferases values. Gastroenterology 109 (1995) 1324-1327
11. Brunt E.M., Janney C.G., Di Bisceglie A.M., Neuschwander-Tetri B.A., and Bacon B.R. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 94 (1999) 2467-2474
12. Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., et al. Design and validation of a histological scoring system for non-alcoholic fatty liver disease. Hepatology 41 (2005) 1313-1321
13. The METAVIR cooperative group. Inter- and intra-observer variation in the assessment of liver biopsy of chronic hepatitis C. Hepatology 1994;20:15-20.
14. Bedogni G., Miglioli L., Masutti F., Tiribelli C., Marchesini G., and Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 42 (2005) 44-52
15. Bardella M.T., Fraquelli M., Quatrini M., Molteni N., Bianchi P., and Conte D. Prevalence of hypertransaminasemia in adult celiac patients and effect of gluten-free diet. Hepatology 22 (1995) 833-836
16. Berasain C., Betes M., Panizo A., Ruiz J., Herrero J.I., Civeira M.P., et al. Pathological and virological findings in patients with persistent hypertransaminasemia of unknown aetiology. Gut 47 (2000) 429-435
17. Castillo I., Pardo M., Bartolome J., Ortiz-Movilla N., Rodriguez-Inigo E., de Lucas S., et al. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Inf Dis 189 (2004) 7-14
18. Pollicino T., Squadrito G., Cerenzia G., Cacciola I., Raffa G., Crax A., et al. Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection. Gastroenterology 126 (2004) 102-110
19. Cadranel J.F., Rufat P., and Degos F. Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF). Hepatology 32 (2000) 477-481
20. Afdhal N.H. Diagnosing fibrosis in hepatitis C: is the pendulum swinging from biopsy to blood tests ?. Hepatology 37 (2003) 972-974
21. Bedossa P., Dargère D., and Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 38 (2003) 1449-1457
22. Angulo P., Keach J.C., Batts K.P., and Lindor K.D. Independent predictors of liver fibrosis in patients with non-alcoholic steatohepatitis. Hepatology 30 (1999) 1356-1362
23. Ratziu V., Giral P., Charlotte F., Bruckert E., Thibault V., Theodorou I., et al. Liver fibrosis in overweight patients. Gastroenterology 118 (2000) 1117-1123
24. Hézode C., Lonjon I., Roudot-Thoraval F., Mavier J.P., Pawlotsky J.M., Zafrani E.S., et al. Impact of smocking on histological liver lesions in chronic hepatitis C. Gut 52 (2003) 126-129
25. Suzuki A., Lindor K., St Saver J., Lymp J., Mendes F., Muto A., et al. Effect of changes on body weight and lifestyle in non-alcoholic fatty liver disease. J Hepatol 43 (2005) 1060-1066
26. Day C.P., and James O.F. Steatohepatitis: a tale of two "hits?. Gastroenterology 114 (1998) 842-845
27. Imbert-Bismut F., Ratziu V., Pieroni L., Charlotte F., Benhamou Y., and Poynard T. Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet 357 (2001) 1069-1075
28. Castéra L., Vergniol J., Foucher J., Le Bail B., Chanteloup E., Haaser M., et al. Prospective comparison of transient elastography, Fibrotest, APRI and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 128 (2005) 343-350