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Volumn 67, Issue 10, 2009, Pages 332-340

The hypothalamus-pituitary-thyroid axis in critical illness

Author keywords

Critical illness; Deiodinase; Hypothalamic TRH; Low T3 syndrome; MCT8; TSH

Indexed keywords

LIOTHYRONINE; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 8; PROTIRELIN; THYROTROPIN; THYROXINE;

EID: 70549089773     PISSN: 03002977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (72)

References (97)
  • 3
    • 0014954713 scopus 로고
    • Starvation in man
    • Cahill GF, Jr. Starvation in man. N Engl J Med. 1970;282(12):668-675
    • (1970) N Engl J Med , vol.282 , Issue.12 , pp. 668-675
    • Cahill Jr., G.F.1
  • 4
    • 0019225772 scopus 로고
    • Decreased extrathyroidal triiodothyronine production in non-thyroidal illness: Benefit or harm?
    • Utiger RD. Decreased extrathyroidal triiodothyronine production in non-thyroidal illness: benefit or harm? Am J Med. 1980;69(6):807-810
    • (1980) Am J Med , vol.69 , Issue.6 , pp. 807-810
    • Utiger, R.D.1
  • 5
    • 0023263008 scopus 로고
    • Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients
    • Streat SJ, Beddoe AH, Hill GL. Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients. J Trauma. 1987;27(3):262-266
    • (1987) J Trauma , vol.27 , Issue.3 , pp. 262-266
    • Streat, S.J.1    Beddoe, A.H.2    Hill, G.L.3
  • 6
    • 0029863077 scopus 로고    scopus 로고
    • A descriptive study of skeletal muscle metabolism in critically ill patients: Free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytes
    • DOI 10.1097/00003246-199604000-00005
    • Gamrin L, Essen P, Forsberg AM, Hultman E, Wernerman J. A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytes. Crit Care Med. 1996;24(4):575-583 (Pubitemid 26133789)
    • (1996) Critical Care Medicine , vol.24 , Issue.4 , pp. 575-583
    • Gamrin, L.1    Essen, P.2    Forsberg, A.M.3    Hultman, E.4    Wernerman, J.5
  • 7
    • 8044224665 scopus 로고    scopus 로고
    • The somatotropic axis in critical illness: Effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion
    • 1
    • Van den Berghe G, de Zegher F, Veldhuis JD, et al. The somatotropic axis in critical illness: effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion. J Clin Endocrinol Metab. 1997 1;82(2):590-599
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.2 , pp. 590-599
    • Van Den Berghe, G.1    De Zegher, F.2    Veldhuis, J.D.3
  • 8
    • 9844253883 scopus 로고    scopus 로고
    • Thyrotrophin and prolactin release in prolonged critical illness: Dynamics of spontaneous secretion and effects of growth hormone-secretagogues
    • Oxf
    • Van den Berghe G, de Zegher F, Veldhuis JD, et al. Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues. Clin Endocrinol (Oxf). 1997;47(5):599-662
    • (1997) Clin Endocrinol , vol.47 , Issue.5 , pp. 599-662
    • Van Den Berghe, G.1    De Zegher, F.2    Veldhuis, J.D.3
  • 9
    • 15644365769 scopus 로고
    • Neuroendocrinology of prolonged critical illness: Effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues
    • Van den Berghe G, de Zegher F, Baxter RC, et al. Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues. J Clin Endocrinol Metab. 1988;83(2):309-319
    • (1988) J Clin Endocrinol Metab , vol.83 , Issue.2 , pp. 309-319
    • Van Den Berghe, G.1    De Zegher, F.2    Baxter, R.C.3
  • 10
    • 0016678226 scopus 로고
    • Reciprocal changes in serum concentrations of 3,3′,5- triiodothyronine (T3) in systemic illnesses
    • Chopra IJ, Chopra U, Smith SR, Reza M, Solomon DH. Reciprocal changes in serum concentrations of 3,3′,5-triiodothyronine (T3) in systemic illnesses. J Clin Endocrinol Metab. 1975;41(6):1043-1049
    • (1975) J Clin Endocrinol Metab , vol.41 , Issue.6 , pp. 1043-1049
    • Chopra, I.J.1    Chopra, U.2    Smith, S.R.3    Reza, M.4    Solomon, D.H.5
  • 11
    • 0034847574 scopus 로고    scopus 로고
    • Dissociation of the early decline in serum T(3) concentration and serum IL-6 rise and TNFalpha in nonthyroidal illness syndrome induced by abdominal surgery
    • Michalaki M, Vagenakis AG, Makri M, Kalfarentzos F, Kyriazopoulou V. Dissociation of the early decline in serum T(3) concentration and serum IL-6 rise and TNFalpha in nonthyroidal illness syndrome induced by abdominal surgery. J Clin Endocrinol Metab. 2001;86(9):4198-4205
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.9 , pp. 4198-4205
    • Michalaki, M.1    Vagenakis, A.G.2    Makri, M.3    Kalfarentzos, F.4    Kyriazopoulou, V.5
  • 12
    • 0018415335 scopus 로고
    • Effect of tri-iodothyronine replacement on the metabolic and pituitary responses to starvation
    • Gardner DF, Kaplan MM, Stanley CA, Utiger RD. Effect of tri-iodothyronine replacement on the metabolic and pituitary responses to starvation. N Engl J Med. 1979;300(11):579-584
    • (1979) N Engl J Med , vol.300 , Issue.11 , pp. 579-584
    • Gardner, D.F.1    Kaplan, M.M.2    Stanley, C.A.3    Utiger, R.D.4
  • 14
    • 0034641545 scopus 로고    scopus 로고
    • Tri-iodothyronine treatment in children after cardiac surgery: A double-blind, randomised, placebo-controlled study
    • Bettendorf M, Schmidt KG, Grulich-Henn J, Ulmer HE, Heinrich UE. Tri-iodothyronine treatment in children after cardiac surgery: a double-blind, randomised, placebo-controlled study. Lancet. 2000;356(9229):529-534 (Pubitemid 30611856)
    • (2000) Lancet , vol.356 , Issue.9229 , pp. 529-534
    • Bettendorf, M.1    Schmidt, K.G.2    Grulich-Henn, J.3    Ulmer, H.E.4    Heinrich, U.E.5
  • 15
    • 0022576606 scopus 로고
    • Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration
    • Brent GA, Hershman JM. Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration. J Clin Endocrinol Metab. 1986;63(1):1-8.
    • (1986) J Clin Endocrinol Metab , vol.63 , Issue.1 , pp. 1-8
    • Brent, G.A.1    Hershman, J.M.2
  • 16
    • 0028808234 scopus 로고
    • Thyroid hormone treatment after coronary-artery bypass surgery
    • Klemperer JD, Klein I, Gomez M, et al. Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med. 1995;333(23):1522-1527
    • (1995) N Engl J Med , vol.333 , Issue.23 , pp. 1522-1527
    • Klemperer, J.D.1    Klein, I.2    Gomez, M.3
  • 17
    • 68549088765 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-thyroid axis changes in children after cardiac surgery
    • Marks SD, Haines C, Rebeyka IM, Couch RM. Hypothalamic-pituitary-thyroid axis changes in children after cardiac surgery. J Clin Endocrinol Metab. 2009;94(8):2781-2786
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.8 , pp. 2781-2786
    • Marks, S.D.1    Haines, C.2    Rebeyka, I.M.3    Couch, R.M.4
  • 18
    • 0031028187 scopus 로고    scopus 로고
    • Effects of thyroxine supplementation on neurologic development in infants born at less than 30 weeks' gestation
    • Van Wassenaer AG, Kok JH, de Vijlder JJ, et al. Effects of thyroxine supplementation on neurologic development in infants born at less than 30 weeks' gestation. N Engl J Med. 1997;336(1):21-26
    • (1997) N Engl J Med , vol.336 , Issue.1 , pp. 21-26
    • Van Wassenaer, A.G.1    Kok, J.H.2    De Vijlder, J.J.3
  • 19
    • 0030924606 scopus 로고    scopus 로고
    • L-thyroxine treatment of preterm newborns: Clinical and endocrine effects
    • Vanhole C, Aerssens P, Naulaers G, et al. L-thyroxine treatment of preterm newborns: clinical and endocrine effects. Pediatr Res. 1997;42(1):87-92.
    • (1997) Pediatr Res , vol.42 , Issue.1 , pp. 87-92
    • Vanhole, C.1    Aerssens, P.2    Naulaers, G.3
  • 21
    • 0029907826 scopus 로고    scopus 로고
    • Nongenomic actions of thyroid hormone
    • Davis PJ, Davis FB. Nongenomic actions of thyroid hormone. Thyroid. 1996;6(5):497-504.
    • (1996) Thyroid , vol.6 , Issue.5 , pp. 497-504
    • Davis, P.J.1    Davis, F.B.2
  • 22
    • 0034964207 scopus 로고    scopus 로고
    • Physiological and molecular basis of Thyroid hormone action
    • Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001;81(3):1097-1142 (Pubitemid 32606667)
    • (2001) Physiological Reviews , vol.81 , Issue.3 , pp. 1097-1142
    • Yen, P.M.1
  • 23
    • 0021063863 scopus 로고
    • Distribution and metabolism of L- and D-triiodothyronine (T3) in the rat: Preferential accumulation of L-T3 by hepatic and cardiac nuclei as a probable explanation of the differential biological potency of T3 enantiomers
    • Schwartz HL, Trence D, Oppenheimer JH, Jiang NS, Jump DB. Distribution and metabolism of L- and D-triiodothyronine (T3) in the rat: preferential accumulation of L-T3 by hepatic and cardiac nuclei as a probable explanation of the differential biological potency of T3 enantiomers. Endocrinology. 1983;113(4):1236-1243
    • (1983) Endocrinology , vol.113 , Issue.4 , pp. 1236-1243
    • Schwartz, H.L.1    Trence, D.2    Oppenheimer, J.H.3    Jiang, N.S.4    Jump, D.B.5
  • 24
    • 0018744359 scopus 로고
    • 1 cells
    • Samuels HH, Stanley F, Casanova J. Relationship of receptor affinity to the modulation of thyroid hormone nuclear receptor levels and growth hormone synthesis by L-triiodothyronine and iodothyronine analogues in cultured GH1 cells. J Clin Invest. 1979;63(6):1229-1240 (Pubitemid 9193219)
    • (1979) Journal of Clinical Investigation , vol.63 , Issue.6 , pp. 1229-1240
    • Samuels, H.H.1    Stanley, F.2    Casanova, J.3
  • 25
    • 0034892914 scopus 로고    scopus 로고
    • Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability
    • DOI 10.1210/er.22.4.451
    • Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev. 2001;22(4):451-476 (Pubitemid 32762323)
    • (2001) Endocrine Reviews , vol.22 , Issue.4 , pp. 451-476
    • Hennemann, G.1    Docter, R.2    Friesema, E.C.H.3    De Jong, M.4    Krenning, E.P.5    Visser, T.J.6
  • 26
    • 0036191639 scopus 로고    scopus 로고
    • Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases
    • Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases. Endocr Rev. 2002;23(1):38-891
    • (2002) Endocr Rev , vol.23 , Issue.1 , pp. 38-891
    • Bianco, A.C.1    Salvatore, D.2    Gereben, B.3    Berry, M.J.4    Larsen, P.R.5
  • 27
    • 4444319183 scopus 로고    scopus 로고
    • Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice
    • DOI 10.1677/joe.0.1820315
    • Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM. Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice. J Endocrinol. 2004;182(2):315-323 (Pubitemid 39199015)
    • (2004) Journal of Endocrinology , vol.182 , Issue.2 , pp. 315-323
    • Boelen, A.1    Kwakkel, J.2    Thijssen-Timmer, D.C.3    Alkemade, A.4    Fliers, E.5    Wiersinga, W.M.6
  • 28
    • 27844520169 scopus 로고    scopus 로고
    • Tissue deiodinase activity during prolonged critical illness: Effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone-releasing peptide-2
    • DOI 10.1210/en.2005-0963
    • Debaveye Y, Ellger B, Mebis L, et al. Tissue deiodinase activity during prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone-releasing peptide-2. Endocrinology. 2005;146(12):5604-5611 (Pubitemid 41653077)
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5604-5611
    • Debaveye, Y.1    Ellger, B.2    Mebis, L.3    Van Herck, E.4    Coopmans, W.5    Darras, V.6    Van Den Berghe, G.7
  • 29
    • 34547749980 scopus 로고    scopus 로고
    • Brief report: The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness
    • DOI 10.1210/jc.2007-0510
    • Mebis L, Langouche L, Visser TJ, van den Berghe G. The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness. J Clin Endocrinol Metab. 2007;92(8):3330-3333 (Pubitemid 47236410)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.8 , pp. 3330-3333
    • Mebis, L.1    Langouche, L.2    Visser, T.J.3    Van Den Berghe, G.4
  • 30
    • 68349138294 scopus 로고    scopus 로고
    • Expression of thyroid hormone transporters during critical illness
    • Mebis L, Paletta D, Debaveye Y, et al. Expression of thyroid hormone transporters during critical illness. Eur J Endocrinol. 2009;161(2):243-250
    • (2009) Eur J Endocrinol , vol.161 , Issue.2 , pp. 243-250
    • Mebis, L.1    Paletta, D.2    Debaveye, Y.3
  • 33
    • 24644436920 scopus 로고    scopus 로고
    • Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
    • Luiza Maia A, Kim BW, Huang SA, Harney JW, Larsen PR. Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest. 2005;115(9):2524-2533
    • (2005) J Clin Invest , vol.115 , Issue.9 , pp. 2524-2533
    • Luiza Maia, A.1    Kim, B.W.2    Huang, S.A.3    Harney, J.W.4    Larsen, P.R.5
  • 34
    • 25144518194 scopus 로고    scopus 로고
    • Cellular and structural biology of the deiodinases
    • Bianco AC, Larsen PR. Cellular and structural biology of the deiodinases. Thyroid. 2005;15(8):777-786
    • (2005) Thyroid , vol.15 , Issue.8 , pp. 777-786
    • Bianco, A.C.1    Larsen, P.R.2
  • 36
    • 0032783726 scopus 로고    scopus 로고
    • Fetal and neonatal hyperthyroidism
    • Zimmerman D. Fetal and neonatal hyperthyroidism. Thyroid. 1999;9(7):727-733
    • (1999) Thyroid , vol.9 , Issue.7 , pp. 727-733
    • Zimmerman, D.1
  • 37
    • 0034691665 scopus 로고    scopus 로고
    • Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas
    • Huang SA, Tu HM, Harney JW, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med. 2000;343(3):185-189
    • (2000) N Engl J Med , vol.343 , Issue.3 , pp. 185-189
    • Huang, S.A.1    Tu, H.M.2    Harney, J.W.3
  • 38
    • 0026612534 scopus 로고
    • A radioimmunoassay for measurement of 3,5,3′-triiodothyronine sulfate: Studies in thyroidal and nonthyroidal diseases, pregnancy, and neonatal life
    • Chopra IJ, Wu SY, Teco GN, Santini F. A radioimmunoassay for measurement of 3,5,3′-triiodothyronine sulfate: studies in thyroidal and nonthyroidal diseases, pregnancy, and neonatal life. J Clin Endocrinol Metab. 1992;75(1):189-194
    • (1992) J Clin Endocrinol Metab , vol.75 , Issue.1 , pp. 189-194
    • Chopra, I.J.1    Wu, S.Y.2    Teco, G.N.3    Santini, F.4
  • 40
    • 28744450413 scopus 로고    scopus 로고
    • Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity
    • Peeters RP, Kester MH, Wouters PJ, et al. Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity. J Clin Endocrinol Metab. 2005;90(12):6460-6465
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.12 , pp. 6460-6465
    • Peeters, R.P.1    Kester, M.H.2    Wouters, P.J.3
  • 41
    • 26244441090 scopus 로고    scopus 로고
    • Euthyroid sick syndrome in meningococcal sepsis: The impact of peripheral thyroid hormone metabolism and binding proteins
    • den Brinker M, Joosten KF, Visser TJ, et al. Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. J Clin Endocrinol Metab. 2005;90(10):5613-5620
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.10 , pp. 5613-5620
    • Den Brinker, M.1    Joosten, K.F.2    Visser, T.J.3
  • 42
    • 0020051327 scopus 로고
    • An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum
    • Crantz FR, Silva JE, Larsen PR. An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology. 1982;110(2):367-375
    • (1982) Endocrinology , vol.110 , Issue.2 , pp. 367-375
    • Crantz, F.R.1    Silva, J.E.2    Larsen, P.R.3
  • 43
    • 0019754949 scopus 로고
    • Relationships between circulating and intracellular thyroid hormones: Physiological and clinical implications
    • Larsen PR, Silva JE, Kaplan MM. Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev. 1981;2(1):87-102.
    • (1981) Endocr Rev , vol.2 , Issue.1 , pp. 87-102
    • Larsen, P.R.1    Silva, J.E.2    Kaplan, M.M.3
  • 44
    • 0014427416 scopus 로고
    • Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones
    • Oppenheimer JH. Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones. N Engl J Med. 1968;278(21):1153-1162
    • (1968) N Engl J Med , vol.278 , Issue.21 , pp. 1153-1162
    • Oppenheimer, J.H.1
  • 46
    • 0014767674 scopus 로고
    • Parameters of thyroid function in serum of 16 selected vertebrate species: A study of PBI, serum T4, free T4, and the pattern of T4 and T3 binding to serum proteins
    • Refetoff S, Robin NI, Fang VS. Parameters of thyroid function in serum of 16 selected vertebrate species: a study of PBI, serum T4, free T4, and the pattern of T4 and T3 binding to serum proteins. Endocrinology. 1970;86(4)793-805.
    • (1970) Endocrinology , vol.86 , Issue.4 , pp. 793-805
    • Refetoff, S.1    Robin, N.I.2    Fang, V.S.3
  • 47
    • 0034046012 scopus 로고    scopus 로고
    • Concordant decreases of thyroxine and thyroxine binding protein concentrations during sepsis
    • Afandi B, Vera R, Schussler GC, Yap MG. Concordant decreases of thyroxine and thyroxine binding protein concentrations during sepsis. Metabolism. 2000;49(6):753-754 (Pubitemid 30354583)
    • (2000) Metabolism: Clinical and Experimental , vol.49 , Issue.6 , pp. 753-754
    • Afandi, B.1    Vera, R.2    Schussler, G.C.3    Yap, M.G.4
  • 49
    • 0021939804 scopus 로고
    • Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3,5,3′-triiodothyronine in sera of patients with nonthyroidal illnesses
    • Chopra IJ, Huang TS, Beredo A, Solomon DH, Chua Teco GN, Mead JF. Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3,5,3′-triiodothyronine in sera of patients with nonthyroidal illnesses. J Clin Endocrinol Metab. 1985;60(4):666-672
    • (1985) J Clin Endocrinol Metab , vol.60 , Issue.4 , pp. 666-672
    • Chopra, I.J.1    Huang, T.S.2    Beredo, A.3    Solomon, D.H.4    Chua Teco, G.N.5    Mead, J.F.6
  • 50
    • 0030051476 scopus 로고    scopus 로고
    • Thyroid hormone metabolism and thyroid diseases in chronic renal failure
    • DOI 10.1210/er.17.1.45
    • Kaptein EM. Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Endocr Rev. 1996;17(1):45-63. (Pubitemid 26061367)
    • (1996) Endocrine Reviews , vol.17 , Issue.1 , pp. 45-63
    • Kaptein, E.M.1
  • 52
    • 0022411903 scopus 로고
    • Measurement of thyroxine uptake from serum by cultured human hepatocytes as an index of thyroid status: Reduced thyroxine uptake from serum of patients with nonthyroidal illness
    • Same DH, Refetoff S. Measurement of thyroxine uptake from serum by cultured human hepatocytes as an index of thyroid status: reduced thyroxine uptake from serum of patients with nonthyroidal illness. J Clin Endocrinol Metab. 1985;61(6):1046-1052 (Pubitemid 16186700)
    • (1985) Journal of Clinical Endocrinology and Metabolism , vol.61 , Issue.6 , pp. 1046-1052
    • Sarne, D.H.1    Refetoff, S.2
  • 53
    • 0029150952 scopus 로고
    • Impaired thyroxine and 3,5,3′-triiodothyronine handling by rat hepatocytes in the presence of serum of patients with nonthyroidal illness
    • Vos RA, de Jong M, Bernard BF, Docter R, Krenning EP, Hennemann G. Impaired thyroxine and 3,5,3′-triiodothyronine handling by rat hepatocytes in the presence of serum of patients with nonthyroidal illness. J Clin Endocrinol Metab. 1995;80(8):2364-2370
    • (1995) J Clin Endocrinol Metab , vol.80 , Issue.8 , pp. 2364-2370
    • Vos, R.A.1    De Jong, M.2    Bernard, B.F.3    Docter, R.4    Krenning, E.P.5    Hennemann, G.6
  • 54
    • 0028283716 scopus 로고
    • Transport of thyroxine into cultured hepatocytes: Effects of mild non-thyroidal illness and calorie restriction in obese subjects
    • Lim CF, Docter R, Krenning EP, et al. Transport of thyroxine into cultured hepatocytes: effects of mild non-thyroidal illness and calorie restriction in obese subjects. Clin Endocrinol (Oxf). 1994;40(1)79-85. (Pubitemid 24193131)
    • (1994) Clinical Endocrinology , vol.40 , Issue.1 , pp. 79-85
    • Lim, C.-F.1    Docter, R.2    Krenning, E.P.3    Van Toor, H.4    Bernard, B.5    De Jong, M.6    Hennemann, G.7
  • 55
    • 0022994667 scopus 로고
    • Carrier-mediated transport of thyroid hormone into rat hepatocytes is rate-limiting in total cellular uptake and metabolism
    • Hennemann G, Krenning EP, Polhuys M, et al. Carrier-mediated transport of thyroid hormone into rat hepatocytes is rate-limiting in total cellular uptake and metabolism. Endocrinology. 1986;119(4):1870-1872 (Pubitemid 17170565)
    • (1986) Endocrinology , vol.119 , Issue.4 , pp. 1870-1872
    • Henneman, G.1    Krenning, E.P.2    Polhuys, M.3
  • 56
    • 0031937583 scopus 로고    scopus 로고
    • The significance of plasma membrane transport in the bioavailability of thyroid hormone
    • DOI 10.1046/j.1365-2265.1998.00377.x
    • Hennemann G, Everts ME, de Jong M, Lim CF, Krenning EP, Docter R. The significance of plasma membrane transport in the bioavailability of thyroid hormone. Clin Endocrinol (Oxf). 1998;48(1):1-8. (Pubitemid 28122426)
    • (1998) Clinical Endocrinology , vol.48 , Issue.1 , pp. 1-8
    • Hennemann, G.1    Everts, M.E.2    De Jong, M.3    Lim, C.-F.4    Krenning, E.P.5    Docter, R.6
  • 57
    • 0029144693 scopus 로고
    • Effects of fasting, intermittent feeding, or continuous parenteral nutrition on rat liver and brain energy metabolism as assessed by 31P-NMR
    • Bodoky G, Yang ZJ, Meguid MM, Laviano A, Szeverenyi N. Effects of fasting, intermittent feeding, or continuous parenteral nutrition on rat liver and brain energy metabolism as assessed by 31P-NMR. Physiol Behav. 1995;58(3):521-527
    • (1995) Physiol Behav , vol.58 , Issue.3 , pp. 521-527
    • Bodoky, G.1    Yang, Z.J.2    Meguid, M.M.3    Laviano, A.4    Szeverenyi, N.5
  • 58
    • 0020319067 scopus 로고
    • Decreased transport of thyroxine (T4), 3,3′,5-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs
    • Krenning EP, Docter R, Bernard B, Visser T, Hennemann G. Decreased transport of thyroxine (T4), 3,3′,5-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs. FEBS Lett. 1982;140(2):229-233
    • (1982) FEBS Lett , vol.140 , Issue.2 , pp. 229-233
    • Krenning, E.P.1    Docter, R.2    Bernard, B.3    Visser, T.4    Hennemann, G.5
  • 59
    • 0028426886 scopus 로고
    • T4 uptake into the perfused rat liver and liver T4 uptake in humans are inhibited by fructose
    • De Jong M, Docter R, Bernard BF, et al. T4 uptake into the perfused rat liver and liver T4 uptake in humans are inhibited by fructose. Am J Physiol. 1994;266(5 Pt 1):E768-75.
    • (1994) Am J Physiol , vol.266 , Issue.5 PART 1
    • De Jong, M.1    Docter, R.2    Bernard, B.F.3
  • 60
    • 0023743945 scopus 로고
    • Normal free thyroxine in critical nonthyroidal illnesses measured by ultrafiltration of undiluted serum and equilibrium dialysis
    • Surks MI, Hupart KH, Pan C, Shapiro LE. Normal free thyroxine in critical nonthyroidal illnesses measured by ultrafiltration of undiluted serum and equilibrium dialysis. J Clin Endocrinol Metab.1988;67(5):1031-1039 (Pubitemid 18277226)
    • (1988) Journal of Clinical Endocrinology and Metabolism , vol.67 , Issue.5 , pp. 1031-1039
    • Surks, M.I.1    Hupart, K.H.2    Pan, C.3    Shapiro, L.E.4
  • 63
    • 0018422190 scopus 로고
    • Misleadingly low free thyroxine index and usefulness of reverse triiodothyronine measurement in nonthyroidal illnesses
    • Chopra IJ, Solomon DH, Hepner GW, Morgenstein AA. Misleadingly low free thyroxine index and usefulness of reverse triiodothyronine measurement in nonthyroidal illnesses. Ann Intern Med. 1979;90(6):905-912
    • (1979) Ann Intern Med , vol.90 , Issue.6 , pp. 905-912
    • Chopra, I.J.1    Solomon, D.H.2    Hepner, G.W.3    Morgenstein, A.A.4
  • 66
    • 0023025178 scopus 로고
    • The c-erb-A protein is a high-affinity receptor for thyroid hormone
    • DOI 10.1038/324635a0
    • Sap J, Munoz A, Damm K, et al. The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature. 1986;324(6098):635-640 (Pubitemid 17206350)
    • (1986) Nature , vol.324 , Issue.6098 , pp. 635-640
    • Sap, J.1    Munoz, A.2    Damm, K.3
  • 67
    • 0022998995 scopus 로고
    • The c-erb-A gene encodes a thyroid hormone receptor
    • DOI 10.1038/324641a0
    • Weinberger C, Thompson CC, Ong ES, Lebo R, Gruol DJ, Evans RM. The c-erb-A gene encodes a thyroid hormone receptor. Nature. 1986;324(6098):641-646 (Pubitemid 17206351)
    • (1986) Nature , vol.324 , Issue.6098 , pp. 641-646
    • Weinberger, C.1    Thompson, C.C.2    Ong, E.S.3
  • 68
    • 0024869336 scopus 로고
    • Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor
    • Brent GA, Dunn MK, Harney JW, Gulick T, Larsen PR, Moore DD. Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol. 1989;1(3):329-336
    • (1989) New Biol , vol.1 , Issue.3 , pp. 329-336
    • Brent, G.A.1    Dunn, M.K.2    Harney, J.W.3    Gulick, T.4    Larsen, P.R.5    Moore, D.D.6
  • 69
    • 0024538351 scopus 로고
    • Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing
    • Koenig RJ, Lazar MA, Hodin RA, et al. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature. 1989;337(6208):659-661
    • (1989) Nature , vol.337 , Issue.6208 , pp. 659-661
    • Koenig, R.J.1    Lazar, M.A.2    Hodin, R.A.3
  • 70
    • 0036431611 scopus 로고    scopus 로고
    • Dynamic neuroendocrine responses to critical illness
    • DOI 10.1016/S0091-3022(02)00006-7, PII S0091302202000067
    • Van den Berghe G. Dynamic neuroendocrine responses to critical illness. Front Neuroendocrinol 2002;23(4):370-391 (Pubitemid 35346212)
    • (2002) Frontiers in Neuroendocrinology , vol.23 , Issue.4 , pp. 370-391
    • Van Den Berghe, G.1
  • 72
    • 0022626962 scopus 로고
    • Relationship between thyrotropin and thyroxine changes during recovery from severe hypothyroxinemia of critical illness
    • Hamblin PS, Dyer SA, Mohr VS, et al. Relationship between thyrotropin and thyroxine changes during recovery from severe hypothyroxinemia of critical illness. J Clin Endocrinol Metab. 1986;62(4):717-722
    • (1986) J Clin Endocrinol Metab , vol.62 , Issue.4 , pp. 717-722
    • Hamblin, P.S.1    Dyer, S.A.2    Mohr, V.S.3
  • 74
    • 0029089310 scopus 로고
    • The role of cytokines in the lipopolysaccharide-induced sick euthyroid syndrome in mice
    • Boelen A, Platvoet-ter Schiphorst MC, Bakker O, Wiersinga WM. The role of cytokines in the lipopolysaccharide-induced sick euthyroid syndrome in mice. J Endocrinol. 1995;146(3):475-483
    • (1995) J Endocrinol , vol.146 , Issue.3 , pp. 475-483
    • Boelen, A.1    Platvoet-ter Schiphorst, M.C.2    Bakker, O.3    Wiersinga, W.M.4
  • 75
    • 0030179447 scopus 로고    scopus 로고
    • Relationship between serum 3,5,3′-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness
    • Boelen A, Schiphorst MC, Wiersinga WM. Relationship between serum 3,5,3′-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness. J Endocrinol Invest. 1996;19(7):480-483
    • (1996) J Endocrinol Invest , vol.19 , Issue.7 , pp. 480-483
    • Boelen, A.1    Schiphorst, M.C.2    Wiersinga, W.M.3
  • 76
    • 7244227780 scopus 로고    scopus 로고
    • Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis
    • DOI 10.1530/eje.0.1510497
    • Boelen A, Kwakkel J, Platvoet-Ter Schiphorst M, et al. Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. Eur J Endocrinol. 2004;151(4):497-502. (Pubitemid 39430269)
    • (2004) European Journal of Endocrinology , vol.151 , Issue.4 , pp. 497-502
    • Boelen, A.1    Kwakkel, J.2    Platvoet-ter Schiphorst, M.3    Mentrup, B.4    Baur, A.5    Koehrle, J.6    Wiersinga, W.M.7
  • 78
    • 0027131203 scopus 로고
    • Association between serum interleukin-6 and serum 3,5,3′- triiodothyronine in nonthyroidal illness
    • Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM. Association between serum interleukin-6 and serum 3,5,3′-triiodothyronine in nonthyroidal illness. J Clin Endocrinol Metab. 1993;77(6):1695-1699
    • (1993) J Clin Endocrinol Metab , vol.77 , Issue.6 , pp. 1695-1699
    • Boelen, A.1    Platvoet-ter Schiphorst, M.C.2    Wiersinga, W.M.3
  • 79
    • 0028919859 scopus 로고
    • Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man
    • Van der Poll T, van Zee KJ, Endert E, et al. Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man. J Clin Endocrinol Metab. 1995;80(4):1341-1346
    • (1995) J Clin Endocrinol Metab , vol.80 , Issue.4 , pp. 1341-1346
    • Van Der Poll, T.1    Van Zee, K.J.2    Endert, E.3
  • 80
    • 0030944073 scopus 로고    scopus 로고
    • Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice
    • Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM. Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice. J Endocrinol. 1997;153(1):115-122 (Pubitemid 27146264)
    • (1997) Journal of Endocrinology , vol.153 , Issue.1 , pp. 115-122
    • Boelen, A.1    Platvoet-ter Schiphorst, M.C.2    Wiersinga, W.M.3
  • 81
    • 70549107639 scopus 로고    scopus 로고
    • Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness
    • Mebis L, Debaveye Y, Ellger B, et al. Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness. Crit Care. 2009;13(5):R147.
    • (2009) Crit Care , vol.13 , Issue.5
    • Mebis, L.1    Debaveye, Y.2    Ellger, B.3
  • 83
    • 24044549667 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is inde pendent of the LPS-induced fall in serum thyroid hormone levels
    • Fekete C, Sarkar S, Christoffolete MA, Emerson CH, Bianco AC, Lechan RM. Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is inde pendent of the LPS-induced fall in serum thyroid hormone levels. Brain Res. 2005;1056(1):97-99
    • (2005) Brain Res , vol.1056 , Issue.1 , pp. 97-99
    • Fekete, C.1    Sarkar, S.2    Christoffolete, M.A.3    Emerson, C.H.4    Bianco, A.C.5    Lechan, R.M.6
  • 84
    • 14244252445 scopus 로고    scopus 로고
    • Ascending brainstem pathways are not involved in lipopolysaccharide- induced suppression of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus
    • DOI 10.1210/en.2004-1429
    • Fekete C, Singru PS, Sarkar S, Rand WM, Lechan RM. Ascending brainstem pathways are not involved in lipopolysaccharide-induced suppression of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus. Endocrinology. 2005;146(3):1357-1363 (Pubitemid 40289323)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1357-1363
    • Fekete, C.1    Singru, P.S.2    Sarkar, S.3    Rand, W.M.4    Lechan, R.M.5
  • 85
    • 0034522236 scopus 로고    scopus 로고
    • Effects of proinflammatory cytokines on anterior pituitary 5′-deiodinase type I and type II
    • DOI 10.1677/joe.0.1670505
    • Baur A, Bauer K, Jarry H, Kohrle J. Effects of proinflammatory cytokines on anterior pituitary 5′-deiodinase type I and type II. J Endocrinol. 2000;167(3):505-515 (Pubitemid 32047558)
    • (2000) Journal of Endocrinology , vol.167 , Issue.3 , pp. 505-515
    • Baur, A.1    Bauer, K.2    Jarry, H.3    Kohrle, J.4
  • 87
    • 33846805764 scopus 로고    scopus 로고
    • Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake
    • DOI 10.1677/joe.1.07056
    • Boelen A, Kwakkel J, Wiersinga WM, Fliers E. Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. J Endocrinol. 2006;191(3):707-714 (Pubitemid 46210295)
    • (2006) Journal of Endocrinology , vol.191 , Issue.3 , pp. 707-714
    • Boelen, A.1    Kwakkel, J.2    Wiersinga, W.M.3    Fliers, E.4
  • 88
    • 33747590148 scopus 로고    scopus 로고
    • Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (Mct) 8-deficient mice
    • DOI 10.1210/en.2006-0390
    • Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S. Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology. 2006;147(9):4036-4043 (Pubitemid 44268357)
    • (2006) Endocrinology , vol.147 , Issue.9 , pp. 4036-4043
    • Dumitrescu, A.M.1    Liao, X.-H.2    Weiss, R.E.3    Millen, K.4    Refetoff, S.5
  • 90
    • 31644446219 scopus 로고    scopus 로고
    • Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis
    • DOI 10.1016/j.peptides.2005.01.033, PII S0196978105004432, The Melanocortin Pathway 2005 Part II
    • Lechan RM, Fekete C. Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Peptides. 2006;27(2):310-325 (Pubitemid 43168170)
    • (2006) Peptides , vol.27 , Issue.2 , pp. 310-325
    • Lechan, R.M.1    Fekete, C.2
  • 92
    • 0000659858 scopus 로고    scopus 로고
    • Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
    • DOI 10.1210/en.138.6.2569
    • Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology. 1997;138(6):2569-2576 (Pubitemid 27215264)
    • (1997) Endocrinology , vol.138 , Issue.6 , pp. 2569-2576
    • Legradi, G.1    Emerson, C.H.2    Ahima, R.S.3    Flier, J.S.4    Lechan, R.M.5
  • 93
    • 0035919144 scopus 로고    scopus 로고
    • Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus
    • DOI 10.1016/S0169-328X(01)00088-2, PII S0169328X01000882
    • Sergeyev V, Broberger C, Hokfelt T. Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus. Brain Res Mol Brain Res. 2001;90(2):93-100. (Pubitemid 32537630)
    • (2001) Molecular Brain Research , vol.90 , Issue.2 , pp. 93-100
    • Sergeyev, V.1    Broberger, C.2    Hokfelt, T.3
  • 95
    • 1642460005 scopus 로고    scopus 로고
    • Is there still a place for dopamine in the modern intensive care unit?
    • Debaveye Y, Van den Berghe G. Is there still a place for dopamine in the modern intensive care unit? Anesth Analg. 2004;98(2):461-468
    • (2004) Anesth Analg , vol.98 , Issue.2 , pp. 461-468
    • Debaveye, Y.1    Van Den Berghe, G.2
  • 96
    • 0029935047 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone in critical illness: From a dopamine- Dependent test to a strategy for increasing low serum triiodothyronine, prolactin, and growth hormone concentrations
    • DOI 10.1097/00003246-199604000-00007
    • Van den Berghe G, de Zegher F, Vlasselaers D, et al. Thyrotropin- releasing hormone in critical illness: from a dopamine-dependent test to a strategy for increasing low serum triiodothyronine, prolactin, and growth hormone concentrations. Crit Care Med. 1996;24(4):590-595 (Pubitemid 26133791)
    • (1996) Critical Care Medicine , vol.24 , Issue.4 , pp. 590-595
    • Van Den Berghe, G.1    De Zegher, F.2    Vlasselaers, D.3    Schetz, M.4    Verwaest, C.5    Ferdinande, P.6    Lauwers, P.7
  • 97
    • 9544232545 scopus 로고    scopus 로고
    • Pituitary responsiveness to GH-releasing hormone, GH-releasing peptide-2 and thyrotrophin-releasing hormone in critical illness
    • Van den Berghe G, de Zegher F, Bowers CY, et al. Pituitary responsiveness to GH-releasing hormone, GH-releasing peptide-2 and thyrotrophin-releasing hormone in critical illness. Clin Endocrinol. 1996;45(3):341-351
    • (1996) Clin Endocrinol , vol.45 , Issue.3 , pp. 341-351
    • Van Den Berghe, G.1    De Zegher, F.2    Bowers, C.Y.3


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