Euthyroid sick syndrome in meningococcal sepsis: The impact of peripheral thyroid hormone metabolism and binding proteins

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 10, 2005, Pages 5613-5620

  Den Brinker, Marieke ^a   Joosten, Koen F M ^a   Visser, Theo J ^b   Hop, Wim C J ^b   De Rijke, Yolanda B ^b   Hazelzet, Jan A ^a   Boonstra, Venje H ^a   Hokken Koelega, Anita C S ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DOPAMINE; ELASTASE; LIOTHYRONINE; THYROID HORMONE; THYROTROPIN; THYROXINE; THYROXINE BINDING GLOBULIN;

ARTICLE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEIODINATION; DISEASE DURATION; DISEASE SEVERITY; EUTHYROID SICK SYNDROME; FEMALE; HORMONE BINDING; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MENINGOCOCCEMIA; MORTALITY; OUTCOMES RESEARCH; PREDICTION; PRIORITY JOURNAL; SEPTIC SHOCK; SULFATION; SURVIVAL; THYROID FUNCTION; THYROID HORMONE METABOLISM; UNIVERSITY HOSPITAL;

CARDIOTONIC AGENTS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DOPAMINE; ENERGY INTAKE; EUTHYROID SICK SYNDROMES; FEMALE; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; IODINE; MALE; MENINGOCOCCAL INFECTIONS; MULTIVARIATE ANALYSIS; SEPSIS; SULFATES; THYROID FUNCTION TESTS; THYROID HORMONES; THYROXINE-BINDING PROTEINS;

EID: 26244441090     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-0888     Document Type: Article

References (37)

1. Van den Berghe G, de Zegher F, Bouillon R 1998 Clinical review 95: acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab 83:1827-1834
2. Docter R, Krenning EP, de Jong M, Hennemann G 1993 The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism. Clin Endocrinol (Oxf) 39:499-518
3. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89
4. Peeters RP, Wouters PJ, Kaptein E, van Toor H, Visser TJ, Van den Berghe G 2003 Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. J Clin Endocrinol Metab 88:3202-3211
5. Visser TJ 1996 Pathways of thyroid hormone metabolism. Acta Med Austr 23:10-16
6. Santini F, Chiovato L, Bartalena L, Lapi P, Palla R, Panichi V, Velluzzi F, Grasso L, Chopra IJ, Martino E, Pinchera A 1996 Study of serum 3,5,3′-triiodothyronine sulfate concentration in patients with systemic non-thyroidal illness. Eur J Endocrinol 134:45-49
7. Afandi B, Schussler GC, Arafeh AH, Boutros A, Yap MG, Finkelstein A 2000 Selective consumption of thyroxine-binding globulin during cardiac bypass surgery. Metabolism 49:270-274
8. 4-binding globulin cleaved by human leukocyte elastase. J Clin Endocrinol Metab 87:1217-1222
9. Van den Berghe G, de Zegher F, Lauwers P 1994 Dopamine suppresses pituitary function in infants and children. Crit Care Med 22:1747-1753
10. Van den Berghe G, de Zegher F, Lauwers P 1994 Dopamine and the sick euthyroid syndrome in critical illness. Clin Endocrinol (Oxf) 41:731-737
11. Uzel N, Neyzi O 1986 Thyroid function in critically ill infants with infections. Pediatr Infect Dis 5:516-519
12. Yildizdas D, Onenli-Mungan N, Yapicioglu H, Topaloglu AK, Sertdemir Y, Yuksel B 2004 Thyroid hormone levels and their relationship to survival in children with bacterial sepsis and septic shock. J Pediatr Endocrinol Metab 17:1435-1442
13. Anand NK, Chandra V, Sinha RS, Chellani H 1994 Evaluation of thyroid functions in critically ill infants. Indian Pediatr 31:1233-1237
14. Zucker AR, Chernow B, Fields AI, Hung W, Burman KD 1985 Thyroid function in critically ill children. J Pediatr 107:552-554
15. Joosten KF, de Kleijn ED, Westerterp M, de Hoog M, Eijck FC, Hop WCJ, Voort EV, Hazelzet JA, Hokken-Koelega AC 2000 Endocrine and metabolic responses in children with meningoccocal sepsis: striking differences between survivors and nonsurvivors. J Clin Endocrinol Metab 85:3746-3753
16. Pollack MM, Ruttimann UE, Getson PR 1988 Pediatric risk of mortality (PRISM) score. Crit Care Med 16:1110-1116
17. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG 1996 The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707-710
18. den Brinker M, Dumas B, Visser TJ, Hop WCJ, Hazelzet JA, Festen DAM, Hokken-Koelega AC, Joosten KFM 2005 Thyroid function and outcome in children who survived meningococcal septic shock. Intensive Care Med 31:970-976
19. Williams FL, Simpson J, Delahunty C, Ogston SA, Bongers-Schokking JJ, Murphy N, van Toor H, Wu SY, Visser TJ, Hume R 2004 Developmental trends in cord and postpartum serum thyroid hormones in preterm infants. J Clin Endocrinol Metab 89:5314-5320
20. Rothwell PM, Udwadia ZF, Lawler PG 1993 Thyrotropin concentration predicts outcome in critical illness. Anaesthesia 48:373-376
21. Ray DC, Macduff A, Drummond GB, Wilkinson E, Adams B, Beckett GJ 2002 Endocrine measurements in survivors and non-survivors from critical illness. Intensive Care Med 28:1301-1308
22. Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM 2004 Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice. J Endocrinol 182:315-323
23. Chopra IJ, Sakane S, Teco GN 1991 A study of the serum concentration of tumor necrosis factor-α in thyroidal and nonthyroidal illnesses. J Clin Endocrinol Metab 72:1113-1116
24. van der Poll T, Romijn JA, Wiersinga WM, Sauerwein HP 1990 Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. J Clin Endocrinol Metab 71:1567-1572
25. LoPresti JS, Eigen A, Kaptein E, Anderson KP, Spencer CA, Nicoloff JT 1989 Alterations in 3,3′5′-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man. J Clin Invest 84:1650-1656
26. van Woensel JB, Biezeveld MH, Biesterbos Alders AM, Eerenberg AJ, Endert E, Hack EC, von Rosenstiel IA, Kuijpers TW 2001 Adrenocorticotropic hormone and cortisol levels in relation to inflammatory response and disease severity in children with meningococcal disease. J Infect Dis 184:1532-1537
27. Gardlund B, Sjolin J, Nilsson A, Roll M, Wickerts CJ, Wretlind B 1995 Plasma levels of cytokines in primary septic shock in humans: correlation with disease severity. J Infect Dis 172:296-301
28. De Kleijn ED, Joosten KF, Van Rijn B, Westerterp M, De Groot R, Hokken-Koelega AC, Hazelzet JA 2002 Low serum cortisol in combination with high adrenocorticotrophic hormone concentrations are associated with poor outcome in children with severe meningococcal disease. Pediatr Infect Dis J 21:330-336
29. Visser TJ 1994 Role of sulfation in thyroid hormone metabolism. Chem Biol Interact 92:293-303
30. Chopra IJ, Wu SY, Teco GN, Santini F 1992 A radioimmunoassay for measurement of 3,5,3′-triiodothyronine sulfate: studies in thyroidal and nonthyroidal diseases, pregnancy, and neonatal life. J Clin Endocrinol Metab 75:189-194
31. Visser TJ 1996 Role of sulfate in thyroid hormone sulfation. Eur J Endocrinol 134:12-14
32. Schussler GC 2000 The thyroxine-binding proteins. Thyroid 10:141-149
33. Jirasakuldech B, Schussler GC, Yap MG, Drew H, Josephson A, Michl J 2000 A characteristic serpin cleavage product of thyroxine-binding globulin appears in sepsis sera. J Clin Endocrinol Metab 85:3996-3999
34. Chopra IJ, Teco GN, Nguyen AH, Solomon DH 1979 In search of an inhibitor of thyroid hormone binding to serum proteins in nonthyroid illnesses. J Clin Endocrinol Metab 49:63-69
35. Lim CF, Stockigt JR, Curtis AJ, Wynne KN, Barlow JW, Topliss DJ 1993 A naturally occurring furan fatty acid enhances drug inhibition of thyroxine binding in serum. Metabolism 42:1468-1474
36. Wood DF, Johnston JM, Johnston DG 1991 Dopamine, the dopamine D2 receptor and pituitary tumours. Clin Endocrinol (Oxf) 35:455-466
37. Goldsmith PC, Cronin MJ, Weiner RI 1979 Dopamine receptor sites in the anterior pituitary. J Histochem Cytochem 27:1205-1207