Molecular cloning and characterization of the human CLOCK gene: Expression in the suprachiasmatic nuclei

Genomics

Volumn 57, Issue 2, 1999, Pages 189-200

  Steeves, Thomas D L ^a   King, David P ^a   Zhao, Yaliang ^a   Sangoram, Ashvin M ^a   Du, Fenghe ^c   Bowcock, Anne M ^c   Moore, Robert Y ^b   Takahashi, Joseph S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; CEREBELLUM; CHROMOSOMAL LOCALIZATION; CHROMOSOME 4; CIRCADIAN RHYTHM; DNA SEQUENCE; EXON; GENE EXPRESSION; GENE ISOLATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; INTRON; MOLECULAR CLONING; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS;

MAMMALIA;

EID: 0344483899     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1998.5675     Document Type: Article

References (92)

1. Albrecht U., Zhong S. S., Eichele G., Lee C. C. A differential response of two putative mammalian circadian regulators,mPer1mPer2, Cell. 91:1997;1055-1064.
2. Allada R., White N. E., So W. V., Hall J. C., Rosbash M. A mutantDrosophilaClockperiodtimeless. Cell. 93:1998;791-804.
3. Altschul S. F., Gish W., Miller W., Myers E. W., Lipman D. J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
4. Antoch M. P., Song E. J., Chang A. M., Vitaterna M. H., Zhao Y., Wilsbacher L. D., Sangoram A. M., King D. P., Pinto L. H., Takahashi J. S. Functional identification of the mouse circadianClock. Cell. 89:1997;655-667.
5. Atchley W. R., Fitch W. M. A natural classification of the basic helix-loop-helix class of transcriptional factors. Proc. Natl. Acad. Sci. USA. 94:1997;5172-5176.
6. Balsalobre A., Damiolo F., Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 93:1998;929-937.
7. Beelman C. A., Parker R. Degradation of mRNA in eukaryotes. Cell. 81:1995;179-183.
8. Bennet S. T., Lucassen A. M., Gough S. C. L. Susceptibility to human type I diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat. Genet. 9:1995;284-291.
9. Brawerman G. mRNA decay: Finding the right targets. Cell. 48:1987;5-6.
10. Breithaupt H., Hildebrandt G., Dohre D. Tolerance to shift of sleep as related to the individual circadian phase position. Ergonomics. 21:1978;767-764.
11. Brunkow M. E., Nagle D. L., Bernstein A., Bucan M. A 1.8 MB YAC contig spanning three members of the receptor tyrosine kinase gene family (Pdgfra, Kit, and Flk1) on mouse chromosome 5. Genomics. 25:1995;421-432.
12. Burbach K. M., Poland A., Bradfield C. A. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc. Natl. Acad. Sci. USA. 89:1992;8185-8189.
13. Czeisler C. A., Kronauer R. E., Mooney J. J., Anderson J. L., Allan J. S. Biological rhythm disorders, depression, and phototherapy: A new hypothesis. Psychiatr. Clin. North Am. 10:1987;686-709.
14. Darlington T. K., Wager-Smith K., Ceriani M. F., Staknis D., Gekakis N., Steeves T. D. L., Weitz C. J., Takahashi J. S., Kay S. A. Closing the circadian loop: CLOCK induced transcription of its own inhibitorspertim. Science. 280:1998;1599-1603.
15. Finch C. E., Tanzi R. E. Genetics of aging. Science. 278:1997;407-411.
16. Folkard S., Monk T. H., Lobban M. C. Towards a predictive test of adjustment to shiftwork. Ergonomics. 22:1979;79-91.
17. L. Science. 270:1995;811-815.
18. Gekakis N., Staknis D., Nguyen H. B., Davis F. C., Wilsbacher L. D., King D. P., Takahashi J. S., Weitz C. J. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280:1998;1564-1569.
19. Gradin K., McGuire J., Wenger R. H., Kvietikova I., Whilelawa M. L., Toftgard R., Tora L., Gassman M., Poellinger L. Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of thearnt. Mol. Cell. Biol. 16:1996;5221-5231.
20. Greenberg D. A. There is more than one way to collect data for linkage analysis. Arch. Gen. Psychiatry. 49:1992;745-750.
21. Hahn M. E., Karchner S. I., Shapiro M. A., Perera S. A. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc. Natl. Acad. Sci. USA. 94:1997;13743-13748.
22. Hall J. C. Are cycling gene products as internal zeitgebers no longer the zeitgeist of chronobiology. Neuron. 17:1996;799-802.
23. Hankinson O. The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35:1995;307-340.
24. Hardin P. E., Hall J. C., Rosbash M. Feedback of theDrosophila period. Nature. 343:1990;536-540.
25. Hildebrant G., Stratmann I. Circadian system response to night work in relation to the individual circadian phase position. Int. Arch. Occup. Environ. Health. 43:1979;73-83.
26. Hoganesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y. Z., Pray-Grant M., Perdew G. H., Bradfield C. A. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272:1997;8581-8593.
27. Horne J. A., Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int. J. Chronobiol. 4:1976;97-110.
28. Huang J. Z., Edery I., Rosbash M. PAS is a dimerization domain common toDrosophila period. Nature. 364:1993;259-262.
29. Ikeda M., Nomura M. cDNA cloning and tissue-specific expression of a novel basic-loop-helix/pas protein (BMAL1) and identification of alternatively spliced variants with alternative translation intiation site usage. Biochem. Biophys. Res. Commun. 233:1997;258-264.
30. Johnson A., Engelman W. Influence of lithium ions on human circadian rhythms. Z. Naturforsch. 35:1980;503-507.
31. Kamei R., Hughes L., Miles L., Dement W. Advanced sleep-wake syndrome studied in a time-isolation facility. Chronobiology. 6:1979;115.
32. Karp R. W. Genetic studies in alcohol research. Am. J. Med. Genet. 54:1994;304-308.
33. Katzenberg D., Young T., Finn L., Lin L, King D. P., Takahashi J. S., Mignot E. ACLOCK. Sleep. 21:1998;569-576.
34. Kennedy G. C., German M. S., Rutter W. J. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat. Genet. 9:1995;293-293.
35. King D. P., Zhao Y. Z., Sangoram A. M., Wilsbacher L. W., Tanaka M., Antoch M. P., Steeves T. D. L., Vitaterna M. H., Kornhauser J. M., Lowrey P. L., Turek F. W., Takahashi J. S. Positional cloning of the mouse circadianClock. Cell. 89:1997a;641-653.
36. 19HKit. Genetics. 146:1997b;1049-1060.
37. Klein D. C., Moore R. Y., Reppert S. M. Suprachiasmatic Nucleus - The Mind's Clock. 1991;Oxford Univ. Press, New York.
38. Konopka R. J., Benzer S. Clock mutants ofDrosophila melanogaster. Proc. Natl. Acad. Sci. USA. 68:1971;2112-2116.
39. Koshy B. T., Zoghbi H. Y. The CAG/polygultamine tract diseases: Gene products and molecular pathogenesis. Brain Pathol. 7:1997;927-942.
40. Kozak M. Effects of long 5′ leader sequences on initiation by eukaryotic ribosomes in vitro. Gene Expr. 1:1991;117-125.
41. Kozak M. Interpreting cDNA sequences: Some insights from studies on translation. Mamm. Genome. 7:1996;563-574.
42. Kupfer D. J., Foster F. G., Coble P., McPartland R. J., Ulrich R. F. The application of EEG sleep for the differential diagnosis of affective disorders. Am. J. Psychiatry. 135:1978;64-67.
43. La Spada A. R., Wilson E. N., Lubahn D. B., Harding A. E., Fischbeck H. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature. 352:1991;77-79.
44. Lavie P., Segal S. Twenty four-hour structure of sleepiness in morning and evening types investigated by ultrashort sleep wake cycle. Sleep. 12:1989;522-528.
45. Makalowski W., Zhang J., Boguski M. S. Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences. Genome Res. 6:1996;846-857.
46. Makalowski W., Boguski M. S. Evolutionary parameters of the transcribed mammalian genome: An analysis of 2,820 orthologous rodent and human sequences. Proc. Natl. Acad. Sci. USA. 95:1998;9407-9412.
47. sDrosophila. EMBO J. 15:1996;6877-6886.
48. Meijer J. H., Rietveld W. J. Neurophysiology of the suprachiasmatic circadian pacemaker in rodents. Physiol. Rev. 69:1989;671-707.
49. Moore R. Y. The organization of the human circadian timing system. Prog. Brain Res. 93:1992a;101-117.
50. Moore R. Y. The SCN and the circadian timing system. Circadian Rhythms. 1992b;Elsevier, Lausanne. p. 26-33.
51. Moore R. Y. Organization of the mammalian circadian system. Chadwick D.J., Ackrill K. Ciba Foundation Symposium on Circadian Clocks and Their Adjustment. 1995;88-106 Wiley, West Sussex.
52. Moore-Ede M. C., Sulzman F. M., Fuller C. A. The Clocks That Time Us. 1982;Harvard Univ. Press, Cambridge.
53. Morgan R., Cheadle A. J. Circadian body temperature in chronic schizophrenia. Br. J. Psychiatry. 129:1976;350-354.
54. Myers M. P., Wager-Smith K., Wesley C., Young M. W., Sehgal A. Positional cloning and sequence analysis of theDrosophilatimeless. Science. 270:1995;805-808.
55. Nagase T., Ishikawa K., Nakajima D., Ohir M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. Prediction of the coding sequences of unidentified human genes VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4:1997;141-150.
56. Nambu J. R., Lewis J. O., Wharton K. A. J., Crews S. T. TheDrosophila single-mined. Cell. 67:1991;1157-1167.
57. Novacek M. J. Mammalian phylogeny: Shaking the tree. Nature. 356:1992;121-125.
58. Parkes J. D., Lock C. B. Genetic factors in sleep disorders. J. Neurol. Neurosurg. Psychiatry Suppl. 1989;101-108.
59. Pittendrigh C. S. On temporal organization in living systems. Harvey Lecture Series. 1961;Academic Press, New York. p. 93-125.
60. Plautz J. D., Kaneko M., Hall J. C., Kay S. A. Independent photoreceptive circadian clocks throughoutDrosophila. Science. 278:1997;1560-1561.
61. Posey T. B, Ford J. A. The morningness-eveningness preference for college students as measured by the Horne and Ostberg questionnaire. Int. J. Chronobiol. 7:1981;141-144.
62. Ralph M. R., Foster R. G., Davis F. C., Menaker M. Transplanted suprachiasmatic nucleus determines circadian period. Science. 247:1990;975-978.
63. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
64. Rosbash M., Allada R., Dembinska M., Guo W. Q., Myai L., Marrus S., Qian Z., Rutila J., Yaglom J., Zeng H. ADrosophila. Cold Spring Harbor Symp. Quant. Biol. 61:1996;265-278.
65. Rutila J. E., Suri V., Myai L., So W. V., Rosbash M., Hall J. C. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription ofDrosophila periodtimeless. Cell. 93:1998;805-814.
66. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
67. Savov A., Angelicheva D., Balassopoulou A., Jordanova A., Noussia-Arvanitakis S., Kalaydjieva L. Double mutant alleles: Are they rare. Hum. Mol. Genet. 4:1995;1169-1171.
68. Schmidt J. V., Bradfield C. A. Ah receptor signaling pathways. Annu. Rev. Cell Dev. Biol. 12:1996;55-89.
69. Sehgal A., Price J. L., Man B., Young M. W. Loss of circadian behavioral rhythms andperDrosophilatimeless. Science. 262:1994;1603-1606.
70. Sehgal A., Rothenfluh-Hilfiker A., Hunter-Ensor M., Chen Y., Myer M., Young M. W. Circadian oscillations and autoregulation oftimeless. Science. 270:1995;808-810.
71. Shapiro D., Blume J. E., Nielsen D. A. Regulation of messenger RNA stability in eukaryotic cells. BioEssays. 6:1986;221-226.
72. Shaw G., Kamen R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 45:1986;659-667.
73. Shearman L. P., Zylka M. J., Weaver D. R., Kolakowski L. F., Reppert S. M. Twoperiod. Neuron. 19:1997;1261-1269.
74. Silver R., Le Sauter J., Tresco P. A., Lehman M. N. A diffusible coupling signal from the tranplanted suprachiasmatic nucleus controlling circadian locomotor rhythms. Nature. 382:1996;810-813.
75. So W. V., Rosbash M. Post-transcriptional regulation contributes toDrosophila. EMBO J. 16:1997;146-155.
76. Spritz R. A., Strunk K. M., Lee S. T., Lu-Kuo J. M., Ward D. C., Le Paslier D., Altherr M. R., Dorman T. E., Moir D. T. A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. Genomics. 22:1994;431-436.
77. Sun S. Z., Albrecht U., Zhuchnko O., Bailey J., Eichele G., Lee C. RIGUI, a putative mammalian ortholog of theDrosophila period. Cell. 90:1997;1003-1011.
78. Tei H., Okamura H., Shigeyoshi Y., Fukahara C., Ozawa R., Hirose M., Sakaki Y. Circadian oscillation of a mammalian homologue of theDrosophila. Nature. 389:1997;512-516.
79. Tosini G., Menaker M. Circadian rhythms in cultured mammalian retina. Science. 272:1996;419-421.
80. Treisman R. Transient accumulation ofc-fosc-fos. Cell. 42:1985;889-902.
81. Turek F. W., Van Reeth O. Circadian rhythms. Fregly M. J., Blatteis C. M. Handbook of Physiology. 1996;1329-1360 Oxford Univ. Press, Oxford.
82. van Cauter E., Turek F. W. Endocrine and other biological rhythms. DeGroot L. Textbook of Endocrinology. 1995;2487-2548 Saunders, Philadelphia.
83. van Coevorden A., Mockel J., Laurent E., Kerkhofs M., L'Hermite-Baleriaux M., Decoster C., Neve P., Van Cauter E. Neuroendocrine rhythms and sleep in aging. Am. J. Physiol. 260:1991;E651-E661.
84. Vitaterna M., King D. P., Chang A. M., Kornhauser J. M., Lowrey P. L., McDonald D., Dove W. F., Pinto W. L., Turek F. W., Takahashi J. S. Mutagenesis and mapping of a mouse gene,Clock, Science. 264:1994;719-725.
85. Wehr T. A., Wirz-Justice A., Goodwin F. K. Phase advance of the circadian sleep-wake cycle as an antidepressant. Science. 206:1979;710-713.
86. Wehr T. A., Goodwin F. K., Wirz-Justice A., Breitmayer J., Craig C. 48-hour sleep-wake cycles in manic-depressive illness. Arch. Gen. Psychiatry. 39:1982;559-565.
87. Wehr T. A., Rosenthal N. E. Seasonality and affective illness. Am. J. Psychiatry. 146:1989;829-839.
88. Weitzman E. D., Czeisler C. A., Coleman R. M. Delayed sleep phase syndrome: A chronobiological disorder with sleep onset insomnia. Arch. Gen. Psychiatry. 38:1981;737-746.
89. Welsh D. K., Logothetis D. E., Meister M., Reppert S. M. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythm. Neuron. 14:1995;697-706.
90. Wilk R., Weizman I., Shilo B. Z. trachealessDrosophila. Genes Dev. 10:1996;93-102.
91. Zeng H., Hardin P. E., Rosbash M. Constitutive overexpression of theDrosophila periodperiod. EMBO J. 13:1994;3590-3598.
92. Zylka M. J., Shearman L. P., Weaver D. R., Reppert S. M. Threeperiod. Neuron. 20:1998;1103-1110.