Patterns of cortical thickness according to APOE genotype in alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 28, Issue 5, 2009, Pages 476-485

  Gutiérrez Galve, Leticia ^a,c,d   Lehmann, Manja ^a   Hobbs, Nicola Z ^a   Clarkson, Matthew J ^a,b   Ridgway, Gerard R ^a,b   Crutch, Sebastian ^a   Ourselin, Sebastien ^a,b   Schott, Jonathan M ^a   Fox, Nick C ^a   Barnes, Josephine ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^d INSTITUTO ARAGONÉS DE CIENCIAS DE LA SALUD   (Spain)

Author keywords

Alzheimer's disease; Apolipoprotein E; Cingulate cortex; Cognitive impairment; Cortical thickness; Hippocampus; Magnetic resonance imaging

Indexed keywords

APOLIPOPROTEIN E4;

AGED; ALZHEIMER DISEASE; APTITUDE TEST; ARTICLE; BRAIN REGION; BRAIN SIZE; CINGULATE GYRUS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENOTYPE; HETEROZYGOTE; HIPPOCAMPUS; HOMOZYGOTE; HUMAN; LATERAL BRAIN VENTRICLE; MALE; NEUROIMAGING; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TEMPORAL LOBE; VOLUMETRY;

AGED; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; ATROPHY; CEREBRAL CORTEX; COGNITION DISORDERS; FEMALE; GENOTYPE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PSYCHOMETRICS;

EID: 70450196266     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000258100     Document Type: Article

References (58)

1. Wimo A, Winblad B, Guero-Torres H, von Strauss E: The magnitude of dementia occurrence in the world. Alzheimer Dis Assoc Disord 2003; 17: 63-67.
2. Godbolt AK, Cipolotti L, Watt H, Fox NC, Janssen JC, Rossor MN: The natural history of Alzheimer disease: A longitudinal presymptomatic and symptomatic study of a familial cohort. Arch Neurol 2004; 61: 1743-1748.
3. Scheltens P, Fox N, Barkhof F, De Carli C: Structural magnetic resonance imaging in the practical assessment of dementia: Beyond exclusion. Lancet Neurol 2002; 1: 13-21.
4. Okuizumi K, Onodera O, Tanaka H, Kobayashi H, Tsuji S, Takahashi H, Oyanagi K, Seki K, Tanaka M, Naruse S, Miyatake T, Mizusawa H, Kanazawa I: APOE-epsilon-4 and early-onset Alzheimers. Nat Genet 1994; 7: 10-11.
5. Meyer MR, Tschanz JT, Norton MC, Welsh-Bohmer KA, Steffens DC, Wyse BW, Breitner JC: APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease. Nat Genet 1998; 19: 321-322.
6. Berg L, McKeel DW Jr, Miller JP, Storandt M, Rubin EH, Morris JC, Baty J, Coats M, Norton J, Goate AM, Price JL, Gearing M, Mirra SS, Saunders AM: Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol 1998; 55: 326-335.
7. Lehtovirta M, Laakso MP, Soininen H, Helisalmi S, Mannermaa A, Helkala EL, Partanen K, Ryynanen M, Vainio P, Hartikainen P, Riekkinen PJ: Volumes of hippocampus, amygdala and frontal-lobe in Alzheimer patients with different apolipoprotein-E genotypes. Neuroscience 1995; 67: 65-72.
8. Geroldi C, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, Soininen H, Trabucchi M, Frisoni GB: Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: A volumetric MRI study. J Neurol Neurosurg Psychiatry 2000; 68: 93-96.
9. Hashimoto M, Yasuda M, Tanimukai S, Matsui M, Hirono N, Kazui H, Mori E: Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease. Neurology 2001; 57: 1461-1466.
10. Pievani M, Rasser PE, Galluzzi S, Benussi L, Ghidoni R, Sabattoli F, Bonetti M, Binetti G, Thompson PM, Frisoni GB: Mapping the effect of APOE epsilon4 on gray matter loss in Alzheimer's disease in vivo. Neuroimage 2009; 45: 1090-1098.
11. Agosta F, Vossel KA, Miller BL, Migliaccio R, Bonasera SJ, Filippi M, Boxer AL, Karydas A, Possin KL, Gorno-Tempini ML: Apolipoprotein E epsilon4 is associated with diseasespecific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia. Proc Natl Acad Sci USA 2009; 106: 2018-2022.
12. Filippini N, Rao A, Wetten S, Gibson RA, Borrie M, Guzman D, Kertesz A, Loy-English I, Williams J, Nichols T, Whitcher B, Matthews PM: Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease. Neuroimage 2009; 44: 724-728.
13. Schott JM, Ridha BH, Crutch SJ, Healy DG, Uphill JB, Warrington EK, Rossor MN, Fox NC: Apolipoprotein E genotype modifies the phenotype of Alzheimer disease. Arch Neurol 2006; 63: 155-156.
14. van der Flier WM, Schoonenboom SN, Pijnenburg YA, Fox NC, Scheltens P: The effect of APOE genotype on clinical phenotype in Alzheimer disease. Neurology 2006; 67: 526-527.
15. Barnes J, Foster J, Boyes RG, Pepple T, Moore EK, Schott JM, Frost C, Scahill RI, Fox NC: A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus. Neuroimage 2008; 40: 1655-1671.
16. Barnes J, Boyes RG, Lewis EB, Schott JM, Frost C, Scahill RI, Fox NC: Automatic calculation of hippocampal atrophy rates using a hippocampal template and the boundary shift integral. Neurobiol Aging 2007; 28: 1657-1663.
17. Barnes J, Scahill RI, Frost C, Schott JM, Rossor MN, Fox NC: Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging. Neurobiol Aging 2008; 29: 1199-1203.
18. Schott JM, Frost C, Whitwell JL, MacManus DG, Boyes RG, Rossor MN, Fox NC: Combining short interval MRI in Alzheimer's disease: Implications for therapeutic trials. J Neurol 2006; 253: 1147-1153.
19. Schott JM, Price SL, Frost C, Whitwell JL, Rossor MN, Fox NC: Measuring atrophy in Alzheimer disease: A serial MRI study over 6 and 12 months. Neurology 2005; 65: 119-124.
20. Schott JM, Crutch SJ, Frost C, Warrington EK, Rossor MN, Fox NC: Neuropsychological correlates of whole brain atrophy in Alzheimer's disease. Neuropsychologia 2008; 46: 1732-1737.
21. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
22. Dale AM, Fischl B, Sereno MI: Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999; 9: 179-194.
23. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-923.
24. Folstein MF, Folstein SE, McHugh PR: 'Minimental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
25. Fischl B, Sereno MI, Dale AM: Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 1999; 9: 195-207.
26. Fischl B, Dale AM: Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA 2000; 97: 11050-11055.
27. Chung MK, Robbins SM, Dalton KM, Davidson RJ, Alexander AL, Evans AC: Cortical thickness analysis in autism with heat kernel smoothing. Neuroimage 2005; 25: 1256-1265.
28. Freeborough PA, Fox NC, Kitney RI: Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans. Comput Methods Programs Biomed 1997; 53: 15-25.
29. Sled JG, Zijdenbos AP, Evans AC: A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 1998; 17: 87-97.
30. Mazziotta JC, Toga AW, Evans A, Fox P, Lancaster J: A probabilistic atlas of the human brain: Theory and rationale for its development. The International Consortium for Brain Mapping (ICBM). Neuroimage 1995; 2: 89-101.
31. Fox NC, Warrington EK, Stevens JM, Rossor MN: Atrophy of the hippocampal formation in early familial Alzheimer's disease. A longitudinal MRI study of at-risk members of a family with an amyloid precursor protein 717Val-Gly mutation. Ann NY Acad Sci 1996; 777: 226-232.
32. Scahill RI, Frost C, Jenkins R, Whitwell JL, Rossor MN, Fox NC: A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch Neurol 2003; 60: 989-994.
33. Whitwell JL, Crum WR, Watt HC, Fox NC: Normalization of cerebral volumes by use of intracranial volume: Implications for longitudinal quantitative MR imaging. AJNR Am J Neuroradiol 2001; 22: 1483-1489.
34. Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM: Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron 2002; 33: 341-355.
35. Jones BF, Barnes J, Uylings HB, Fox NC, Frost C, Witter MP, Scheltens P: Differential regional atrophy of the cingulate gyrus in Alzheimer disease: A volumetric MRI study. Cereb Cortex 2006; 16: 1701-1708.
36. Genovese CR, Lazar NA, Nichols T: Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 2002; 15: 870-878.
37. Free SL, Bergin PS, Fish DR, Cook MJ, Shorvon SD, Stevens JM: Methods for normalization of hippocampal volumes measured with MR. AJNR Am J Neuroradiol 1995; 16: 637-643.
38. Galton CJ, Patterson K, Xuereb JH, Hodges JR: Atypical and typical presentations of Alzheimer's disease: A clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain 2000; 123: 484-498.
39. Braak H, Braak E: Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 1995; 16: 271-278.
40. Lerch JP, Pruessner JC, Zijdenbos A, Hampel H, Teipel SJ, Evans AC: Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy. Cereb Cortex 2005; 15: 995-1001.
41. Singh V, Chertkow H, Lerch JP, Evans AC, Dorr AE, Kabani NJ: Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease. Brain 2006; 129: 2885-2893. (Pubitemid 44684510)
42. Du AT, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin K, Miller BL, Weiner MW: Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Brain 2007; 130: 1159-1166.
43. Im K, Lee JM, Seo SW, Yoon U, Kim ST, Kim YH, Kim SI, Na DL: Variations in cortical thickness with dementia severity in Alzheimer's disease. Neurosci Lett 2008; 436: 227-231.
44. Basso M, Yang J, Warren L, MacAvoy MG, Varma P, Bronen RA, van Dyck CH: Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Res 2006; 146: 251-261.
45. Baron JC, Chetelat G, Desgranges B, Perchey G, Landeau B, de la Sayette V, Eustache F: In vivo mapping of gray matter loss with voxelbased morphometry in mild Alzheimer's disease. Neuroimage 2001; 14: 298-309.
46. Frisoni GB, Testa C, Zorzan A, Sabattoli F, Beltramello A, Soininen H, Laakso MP: Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry. J Neurol Neurosurg Psychiatry 2002; 73: 657-664.
47. Karas GB, Scheltens P, Rombouts SA, Visser PJ, van Schijndel RA, Fox NC, Barkhof F: Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. Neuroimage 2004; 23: 708-716.
48. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE, Small GW, Roses AD, Haines JL, Pericakvance MA: Protective effect of apolipoprotein-E type-2 allele for late-onset Alzheimer disease. Nat Genet 1994; 7: 180-184.
49. Boccardi M, Sabattoli F, Testa C, Beltramello A, Soininen H, Frisoni GB: APOE and modulation of Alzheimer's and frontotemporal dementia. Neurosci Lett 2004; 356: 167-170.
50. Pennanen C, Testa C, Boccardi M, Laakso MP, Hallikainen M, Helkala EL, Hanninen T, Kivipelto M, Kononen M, Nissinen A, Tervo S, Vanhanen M, Vanninen R, Frisoni GB, Soininen H: The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: A voxel-based morphometric study. Dement Geriatr Cogn Disord 2006; 22: 60-66.
51. Thomann PA, Roth AS, Dos Santos V, Toro P, Essig M, Schroder J: Apolipoprotein E polymorphism and brain morphology in mild cognitive impairment. Dement Geriatr Cogn Disord 2008; 26: 300-305.
52. Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, Ryynanen M, Kuikka J, Hartikainen P, Riekinnen PJ: SPECT and MRI analysis in Alzheimer's disease: Relation to apolipoprotein E epsilon 4 allele. J Neurol Neurosurg Psychiatry 1996; 60: 644-649.
53. Geroldi C, Pihlajamaki M, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, Soininen H, Trabucchi M, Frisoni GB: APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD. Neurology 1999; 53: 1825-1832.
54. Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Waring SC, Tangalos EG, Smith GE, Ivnik RJ, Thibodeau SN, Kokmen E: Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol 1998; 43: 303-310.
55. Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, O'Brien JT: Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias. Arch Neurol 1999; 56: 961-965.
56. Snowden JS, Stopford CL, Julien CL, Thompson JC, Davidson Y, Gibbons L, Pritchard A, Lendon CL, Richardson AM, Varma A, Neary D, Mann DMA: Cognitive phenotypes in Alzheimer's disease and genetic risk. Cortex 2007; 43: 835-845.
57. Jenkins R, Fox NC, Rossor AM, Harvey RJ, Rossor MN: Intracranial volume and Alzheimer disease: Evidence against the cerebral reserve hypothesis. Arch Neurol 2000; 57: 220-224.
58. Birks J: Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 2006; 1:CD005593.