The effect of APOE genotype on clinical phenotype in Alzheimer disease

Neurology

Volumn 67, Issue 3, 2006, Pages 526-527

  Van Der Flier, W M ^a   Schoonenboom, S N M ^a,b   Pijnenburg, Y A L ^a   Fox, N C ^c   Scheltens, P ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ANAMNESIS; ARTICLE; CONFIDENCE INTERVAL; DISEASE ASSOCIATION; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT;

ALZHEIMER DISEASE; APOLIPOPROTEINS E; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE;

EID: 33747059031     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000228222.17111.2a     Document Type: Article

References (9)

1. Galton CJ, Patterson K, Xuereb JH, Hodges JR. Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain 2000;123:484-498.
2. Greicius MD, Geschwind MD, Miller BL. Presenile dementia syndromes: an update on taxonomy and diagnosis. J Neurol Neurosurg Psychiatry 2002;72:691-700.
3. Strittmatter WJ, Roses AD. Apolipoprotein E and Alzheimer disease. Proc Natl Acad Sci USA 1995;92:4725-4727.
4. Slooter AJ, Cruts M, Kalmijn S, et al. Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch Neurol 1998;55:964-968.
5. Marra C, Bizzarro A, Daniele A, et al. Apolipoprotein E epsilon4 allele differently affects the patterns of neuropsychological presentation in early- and late-onset Alzheimer's disease patients. Dement Geriatr Cogn Disord 2004;18:125-131.
6. Lehtovirta M, Soininen H, Helisalmi S, et al. Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism. Neurology 1996;46:413-419.
7. Schott JM, Ridha BH, Crutch SJ, et al. Apolipoprotein e genotype modifies the phenotype of Alzheimer disease. Arch Neurol 2006;63:155-156.
8. Schoonenboom NS, Pijnenburg YA, Mulder C, et al. Amyloid beta(1-42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease. Neurology 2004;62:1580-1584.
9. Vollbach H, Heun R, Morris CM, et al. APOA1 polymorphism influences risk for early-onset nonfamiliar AD. Ann Neurol 2005;58:436-441.