Feedback regulation of mitochondria by caspase-9 in the B cell receptor-mediated apoptosis

Scandinavian Journal of Immunology

Volumn 70, Issue 6, 2009, Pages 574-583

  Eeva, J ^a   Nuutinen, U ^a   Ropponen, A ^a   Matto M ^a   Eray, M ^b   Pellinen, R ^a   Wahlfors, J ^b,c   Pelkonen, J ^a,d  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CASPASE 8; CASPASE 9; CH 11; CYTOCHROME C; DNA; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; PROTEIN BCL XL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; EXPERIMENTAL STUDY; FEEDBACK SYSTEM; FOLLICULAR LYMPHOMA; GENETIC TRANSFECTION; GERMINAL CENTER; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION;

AMINO ACID CHLOROMETHYL KETONES; ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTES; BCL-X PROTEIN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; DNA FRAGMENTATION; FEEDBACK, PHYSIOLOGICAL; GERMINAL CENTER; HUMANS; IMMUNOLOGIC FACTORS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OLIGOPEPTIDES; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 70449894629     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2009.02331.x     Document Type: Article

References (40)

1. Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol 2008 8 : 22 33.
2. Hennino A, Berard M, Krammer PH, Defrance T. FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis. J Exp Med 2001 193 : 447 458.
3. Hao Z, Duncan GS, Seagal J et al. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity 2008 29 : 615 627.
4. Billian G, Mondiere P, Berard M, Bella C, Defrance T. Antigen receptor-induced apoptosis of human germinal center B cells is targeted to a centrocytic subset. Eur J Immunol 1997 27 : 405 414.
5. Eray M, Postila V, Eeva J et al. Follicular lymphoma cell lines, an in vitro model for antigenic selection and cytokine-mediated growth regulation of germinal centre B cells. Scand J Immunol 2003 57 : 545 555.
6. Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 2003 304 : 437 444.
7. Gogvadze V, Orrenius S, Zhivotovsky B. Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim Biophys Acta 2006 1757 : 639 647.
8. Li P, Nijhawan D, Budihardjo I et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997 91 : 479 489.
9. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998 281 : 1312 1316.
10. Lakhani SA, Masud A, Kuida K et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 2006 311 : 847 851.
11. Ashkenazi A, Dixit VM. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 1999 11 : 255 260.
12. Medema JP, Scaffidi C, Kischkel FC et al. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 1997 16 : 2794 2804.
13. Donepudi M, Mac Sweeney A, Briand C, Grutter MG. Insights into the regulatory mechanism for caspase-8 activation. Mol Cell 2003 11 : 543 549.
14. Scaffidi C, Fulda S, Srinivasan A et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 1998 17 : 1675 1687.
15. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998 94 : 491 501.
16. Sarnesto A, Ranta S, Seppala IJ, Makela O. Relative immunogenicity in mice of different regions of the human IgG. Scand J Immunol 1983 17 : 507 511.
17. Nuutinen U, Simelius N, Ropponen A et al. PDTC enables type I TRAIL signaling in type II follicular lymphoma cells. Leuk Res 2008 33 : 829 836.
18. Eeva J, Nuutinen U, Ropponen A et al. The involvement of mitochondria and the caspase-9-activation pathway in rituximab-induced apoptosis in FL cells. Apoptosis 2009 14 : 687 698.
19. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991 139 : 271 279.
20. Castedo M, Ferri K, Roumier T, Metivier D, Zamzami N, Kroemer G. Quantitation of mitochondrial alterations associated with apoptosis. J Immunol Methods 2002 265 : 39 47.
21. Eeva J, Postila V, Matto M et al. Kinetics and signaling requirements of CD40-mediated protection from B cell receptor-induced apoptosis. Eur J Immunol 2003 33 : 2783 2791.
22. Besnault L, Schrantz N, Auffredou MT, Leca G, Bourgeade MF, Vazquez A. B cell receptor cross-linking triggers a caspase-8-dependent apoptotic pathway that is independent of the death effector domain of Fas-associated death domain protein. J Immunol 2001 167 : 733 740.
23. Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 2001 276 : 20633 20640.
24. Chen W, Wang HG, Srinivasula SM, Alnemri ES, Cooper NR. B cell apoptosis triggered by antigen receptor ligation proceeds via a novel caspase-dependent pathway. J Immunol 1999 163 : 2483 2491.
25. Eldering E, Mackus WJ, Derks IA et al. Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation. Eur J Immunol 2004 34 : 1950 1960.
26. Andjelic S, Liou HC. Antigen receptor-induced B lymphocyte apoptosis mediated via a protease of the caspase family. Eur J Immunol 1998 28 : 570 581.
27. Denecker G, Dooms H, Van Loo G et al. Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential. FEBS Lett 2000 465 : 47 52.
28. Herold MJ, Kuss AW, Kraus C, Berberich I. Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells. J Immunol 2002 168 : 3902 3909.
29. Katz E, Lord C, Ford CA, Gauld SB, Carter NA, Harnett MM. Bcl-(xL) antagonism of BCR-coupled mitochondrial phospholipase A(2) signaling correlates with protection from apoptosis in WEHI-231 B cells. Blood 2004 103 : 168 176.
30. Takada E, Hata K, Mizuguchi J. Requirement for JNK-dependent upregulation of BimL in anti-IgM-induced apoptosis in murine B lymphoma cell lines WEHI-231 and CH31. Exp Cell Res 2006 312 : 3728 3738.
31. Jiang A, Clark EA. Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis. J Immunol 2001 166 : 6025 6033.
32. Malissein E, Verdier M, Ratinaud MH, Troutaud D. Changes in bad phosphorylation are correlated with BCR-induced apoptosis of WEHI-231 immature B cells. Biochimie 2003 85 : 733 740.
33. Berard M, Mondiere P, Casamayor-Palleja M, Hennino A, Bella C, Defrance T. Mitochondria connects the antigen receptor to effector caspases during B cell receptor-induced apoptosis in normal human B cells. J Immunol 1999 163 : 4655 4662.
34. Bouchon A, Krammer PH, Walczak H. Critical role for mitochondria in B cell receptor-mediated apoptosis. Eur J Immunol 2000 30 : 69 77.
35. Chen Q, Gong B, Almasan A. Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death Differ 2000 7 : 227 233.
36. Ricci JE, Munoz-Pinedo C, Fitzgerald P et al. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 2004 117 : 773 786.
37. Cheng EH, Kirsch DG, Clem RJ et al. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 1997 278 : 1966 1968.
38. Chen M, Guerrero AD, Huang L et al. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem 2007 282 : 33888 33895.
39. Skommer J, Wlodkowic D, Deptala A. Larger than life: mitochondria and the Bcl-2 family. Leuk Res 2007 31 : 277 286.
40. Riedl SJ, Salvesen GS. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 2007 8 : 405 413.