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Volumn 31, Issue 1, 2009, Pages 79-98

Towards an integrated view of the neoplastic phenomena in cancer research

Author keywords

Cancer research; Complexity; Epistemology; Reductionism

Indexed keywords

ARTICLE; HISTORY; HUMAN; KNOWLEDGE; MEDICAL RESEARCH; NEOPLASM; PHILOSOPHY;

EID: 70449728159     PISSN: 03919714     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (14)

References (73)
  • 1
    • 0036655497 scopus 로고    scopus 로고
    • Understanding Cancer as a formless phenomenon
    • Aranda-Anzaldo A., 2002, "Understanding Cancer As a Formless Phenomenon", Medical Hypotheses, 59: 68-75.
    • (2002) Medical Hypotheses , vol.59 , pp. 68-75
    • Aranda-Anzaldo, A.1
  • 3
    • 48349084126 scopus 로고    scopus 로고
    • Beyond the oncogene paradigm: Understanding complexity in cancerogenesis
    • Bizzarri M. et al., 2008, "Beyond the Oncogene Paradigm: Understanding Complexity in Cancerogenesis", Acta Biotheoretica, 56: 173-196.
    • (2008) Acta Biotheoretica , vol.56 , pp. 173-196
    • Bizzarri, M.1
  • 4
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • Bjornsson H. T., Fallin M. D., Feinberg A. P., 2004, "An Integrated Epigenetic and Genetic Approach to Common Human Disease", Trends in Genetics, 20: 350-358.
    • (2004) Trends in Genetics , vol.20 , pp. 350-358
    • Bjornsson, H.T.1    Fallin, M.D.2    Feinberg, A.P.3
  • 5
    • 0035503499 scopus 로고    scopus 로고
    • What does it all mean to you?
    • Bloom F. E., 2001, "What Does it All Mean to you?", The Journal of Neuroscience, 21: 8304-8305.
    • (2001) The Journal of Neuroscience , vol.21 , pp. 8304-8305
    • Bloom, F.E.1
  • 6
    • 33644647421 scopus 로고    scopus 로고
    • The long past of systems biology
    • Bothwell J. H., 2006, "The Long Past of Systems Biology", New Phytologist, 170: 6-10.
    • (2006) New Phytologist , vol.170 , pp. 6-10
    • Bothwell, J.H.1
  • 8
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J., Pollard J. W., 2006, "Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis", Cell, 124: 263-266.
    • (2006) Cell. , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 9
    • 0037436509 scopus 로고    scopus 로고
    • Loss of IGF2 imprinting: A potential marker of colorectal Cancer risk
    • Cui H. et al. 2003, "Loss of IGF2 Imprinting: a Potential Marker of Colorectal Cancer Risk", Science, 299: 1753-1755.
    • (2003) Science , vol.299 , pp. 1753-1755
    • Cui, H.1
  • 10
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • DOI 10.1146/annurev.med.58.062105.204854
    • Dalerba P., Cho R. W., Clarke M. F., 2007, "Cancer Stem Cells: Models and Concepts", Annual Review of Medicine, 58: 267-284. (Pubitemid 46706514)
    • (2007) Annual Review of Medicine , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 11
    • 0004149207 scopus 로고
    • Oxford: Oxford University Press
    • Dawkins R., 1976, The Selfish Gene, Oxford: Oxford University Press.
    • (1976) The Selfish Gene
    • Dawkins, R.1
  • 14
    • 40149091137 scopus 로고    scopus 로고
    • Modeling Cancer progression via pathway dependencies
    • Edelman E. J. et al., 2008, "Modeling Cancer Progression via Pathway Dependencies", PLoS Computational Biology, 4: e28.
    • (2008) PLoS Computational Biology , vol.4
    • Edelman, E.J.1
  • 15
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg A. P, Vogelstein B., 1983, "Hypomethylation Distinguishes Genes of Some Human Cancers from Their Normal Counterparts", Nature, 301: 89-92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 18
    • 5644294349 scopus 로고    scopus 로고
    • Combined total genome loss of heterozygosity scan of breast Cancer stroma and epithelium reveals multiplicity of stromal targets
    • Fumino K. et. al., 2004, "Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets", Cancer Research, 64: 7231-7236.
    • (2004) Cancer Research , vol.64 , pp. 7231-7236
    • Fumino, K.1
  • 19
  • 20
    • 0021101229 scopus 로고
    • The 5-methylcytosine content of dna from human tumors
    • Gama-Sosa M. A. et al., 1983, "The 5-methylcytosine Content of DNA from Human Tumors", Nucleic Acids Research, 11: 6883-6894.
    • (1983) Nucleic Acids Research , vol.11 , pp. 6883-6894
    • Gama-Sosa, M.A.1
  • 21
    • 14944342600 scopus 로고    scopus 로고
    • Reducing false positives in molecular pattern recognition
    • Ge X. et al., 2003, "Reducing False Positives in Molecular Pattern Recognition", Genome Inform, 14: 34-43.
    • (2003) Genome Inform , vol.14 , pp. 34-43
    • Ge, X.1
  • 22
    • 0021950948 scopus 로고
    • Hypomethylation of DNA from benign and malignant human colon neoplasms
    • Goelz S. E. et. al., 1985, "Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms", Science, 228: 187-190.
    • (1985) Science , vol.228 , pp. 187-190
    • Goelz, S.E.1
  • 23
    • 4043088499 scopus 로고    scopus 로고
    • Ikkbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten F. R. et al., 2004, "IKKbeta links Inflammation and Tumorigenesis in a Mouse Model of Colitis-associated Cancer", Cell, 118: 285-296.
    • (2004) Cell. , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 24
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Hahn W. C., Weinberg R. A., 2002, "Modelling the Molecular Circuitry of Cancer", Nature Reviews Cancer, 2: 331-342.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 331-342
    • Hahn, W.C.1    Weinberg, R.A.2
  • 25
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R. A., 2000, "The Hallmarks of Cancer", Cell, 100: 57-70.
    • (2000) Cell. , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 26
    • 1642512402 scopus 로고    scopus 로고
    • Tumour suppression: Putting on the brakes
    • Harris H., 2004, "Tumour Suppression: Putting on the Brakes", Nature, 427: 201.
    • (2004) Nature, 427: 201
    • Harris, H.1
  • 27
    • 0004027213 scopus 로고    scopus 로고
    • Part I, London: BC Decker Inc Hamilton
    • Holland J. F., 2003, Cancer Medicine, Part I, London: BC Decker Inc Hamilton.
    • (2003) Cancer Medicine
    • Holland, J.F.1
  • 28
    • 32044451325 scopus 로고    scopus 로고
    • Cancer: A systems biology disease
    • Hornberg J. J. et al., 2006, "Cancer: a Systems Biology Disease", BioSystems, 83: 81-90.
    • (2006) BioSystems , vol.83 , pp. 81-90
    • Hornberg, J.J.1
  • 29
    • 0347379799 scopus 로고    scopus 로고
    • Epigenetic theories of Cancer initiation
    • Jaffe L. F., 2003, "Epigenetic Theories of Cancer Initiation", Advances in Cancer Research, 90: 209-230.
    • (2003) Advances in Cancer Research , vol.90 , pp. 209-230
    • Jaffe, L.F.1
  • 30
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones P. A., Baylin S. B., 2007, "The Epigenomics of Cancer", Cell, 128: 683-692.
    • (2007) Cell. , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 32
    • 72149095241 scopus 로고    scopus 로고
    • Wnt10B.
    • doi:10.1038/mp.a002375.01 31 Jul. 2008
    • Katoh M., 2008, "Wnt10b." UCSD-Nature Molecule Pages, doi:10.1038/mp.a002375.01 (31 Jul. 2008).
    • (2008) UCSD-Nature Molecule Pages
    • Katoh, M.1
  • 33
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler K. W., Volgestein B., 1996, "Lessons from Hereditary Colorectal Cancer", Cell, 87: 159-170.
    • (1996) Cell. , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Volgestein, B.2
  • 34
    • 1542619848 scopus 로고    scopus 로고
    • Cancer as a robust system: Implications for anticancer therapy
    • Kitano H., 2004, "Cancer as a Robust System: Implications for Anticancer Therapy", Nature Reviews Cancer, 4: 227-235.
    • (2004) Nature Reviews Cancer , vol.4 , pp. 227-235
    • Kitano, H.1
  • 36
    • 12444296551 scopus 로고    scopus 로고
    • For tissue organization theory of cancer, a difficult road to acceptance
    • Longtin R., 2005, "For Tissue Organization Theory of Cancer, a Difficult Road to Acceptance", Journal of the National Cancer Institute, 97: 11-12.
    • (2005) Journal of the National Cancer Institute , vol.97 , pp. 11-12
    • Longtin, R.1
  • 37
    • 15944417843 scopus 로고    scopus 로고
    • An integrated approach: Systems biology seeks order in complexity
    • Longtin R., 2005, "An Integrated Approach: Systems Biology Seeks Order in Complexity", Journal of the National Cancer Institute, 97: 476-478.
    • (2005) Journal of the National Cancer Institute , vol.97 , pp. 476-478
    • Longtin, R.1
  • 38
    • 0036295665 scopus 로고    scopus 로고
    • Mechanism of androgen action on cell proliferation as3 protein as a mediator of proliferative arrest in the rat prostate
    • Maffini M. V. et al., 2002, "Mechanism of Androgen Action on Cell Proliferation AS3 Protein as a Mediator of Proliferative Arrest in the Rat Prostate", Endocrinology, 143: 2708-2714.
    • (2002) Endocrinology , vol.143 , pp. 2708-2714
    • Maffini, M.V.1
  • 39
    • 2342441403 scopus 로고    scopus 로고
    • The stroma as a crucial target in rat mammary gland carcinogenesis
    • Maffini M. V. et al., 2004, "The Stroma as a Crucial Target in Rat Mammary Gland Carcinogenesis", Journal of Cell Science, 117: 1495-1502.
    • (2004) Journal of Cell. Science , vol.117 , pp. 1495-1502
    • Maffini, M.V.1
  • 40
    • 27544510187 scopus 로고    scopus 로고
    • Stromal regulation of neoplastic development: Age-dependent normalization of neoplastic mammary cells by mammary stroma
    • Maffini M. V. et al., 2005, "Stromal Regulation of Neoplastic Development: Age-dependent Normalization of Neoplastic Mammary Cells by Mammary Stroma", American Journal of Pathology, 167: 1405-1410.
    • (2005) American Journal of Pathology , vol.167 , pp. 1405-1410
    • Maffini, M.V.1
  • 41
    • 47749145379 scopus 로고    scopus 로고
    • Does prostate Cancer co-opt the developmental program?
    • Marker P. C., 2008, "Does Prostate Cancer Co-opt the Developmental Program?", Differentiation, 76: 736-744.
    • (2008) Differentiation , vol.76 , pp. 736-744
    • Marker, P.C.1
  • 45
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell P. C., 1976, "The Clonal Evolution of Tumor Cell Populations", Science, 194: 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 46
    • 33947413562 scopus 로고    scopus 로고
    • Unraveling the complex regulation of stem cells: Implications for aging and cancer
    • Oakley E. J., Zant G. V., 2007, "Unraveling the Complex Regulation of Stem Cells: Implications for Aging and Cancer", Leukemia, 21: 612-621.
    • (2007) Leukemia , vol.21 , pp. 612-621
    • Oakley, E.J.1    Zant, G.V.2
  • 47
    • 0035895515 scopus 로고    scopus 로고
    • Dissecting human disease in the postgenomic era
    • Peltonen L., McKusick V. A., 2001, "Dissecting Human Disease in the Postgenomic Era", Science, 291: 1224-1229.
    • (2001) Science , vol.291 , pp. 1224-1229
    • Peltonen, L.1    McKusick, V.A.2
  • 48
    • 0036469172 scopus 로고    scopus 로고
    • Metabolomics and microarrays for improved understanding of phenotypic characteristics controlled by both genomic and environmental constraints
    • Phelps T. J., Palombo A. V., Beliaev A. S., 2002, "Metabolomics and Microarrays for Improved Understanding of Phenotypic Characteristics Controlled by both Genomic and Environmental Constraints", Current Opinion in Biotechnology, 13: 20-24.
    • (2002) Current Opinion in Biotechnology , vol.13 , pp. 20-24
    • Phelps, T.J.1    Palombo, A.V.2    Beliaev, A.S.3
  • 49
    • 33745614062 scopus 로고    scopus 로고
    • Stem cells, ageing and the quest for immortality
    • Rando T. A., 2006, "Stem Cells, Ageing and the Quest for Immortality", Nature, 441: 1080-1086.
    • (2006) Nature , vol.441 , pp. 1080-1086
    • Rando, T.A.1
  • 50
    • 38349168094 scopus 로고    scopus 로고
    • Oncogene-induced plasticity and Cancer stem cells
    • Rapp U. R., Meteci F., Schreck R., 2008, "Oncogene-induced Plasticity and Cancer Stem Cells", Cell Cycle, 7: 45-51.
    • (2008) Cell. Cycle , vol.7 , pp. 45-51
    • Rapp, U.R.1    Meteci, F.2    Schreck, R.3
  • 51
    • 0035930134 scopus 로고    scopus 로고
    • Loss of imprinting of insulin-like growth factor-ii (IGF2) gene in distinguishing specific biologic subtypes of wilms tumor
    • Ravenel J. D., 2001, "Loss of Imprinting of Insulin-like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor", Journal of the National Cancer Institute, 93: 1698-1703.
    • (2001) Journal of the National Cancer Institute , vol.93 , pp. 1698-1703
    • Ravenel, J.D.1
  • 52
    • 0019960812 scopus 로고
    • A point mutation is responsible for the acquisition of transforming properties by the t24 human bladder carcinoma oncogene
    • Reddy E. P. et al., 1982, "A Point Mutation is Responsible for the Acquisition of Transforming Properties by the T24 Human Bladder Carcinoma Oncogene", Nature, 300: 149-152.
    • (1982) Nature , vol.300 , pp. 149-152
    • Reddy, E.P.1
  • 53
    • 0034527504 scopus 로고    scopus 로고
    • Modelling in surgical oncology. Part iii: Massive data sets and complex systems
    • Rew D. A., 2000, "Modelling in Surgical Oncology. Part III: Massive Data Sets and Complex Systems", European Journal of Surgical Oncology, 26: 805-809.
    • (2000) European Journal of Surgical Oncology , vol.26 , pp. 805-809
    • Rew, D.A.1
  • 56
    • 0034524531 scopus 로고    scopus 로고
    • Somatic mutation theory of carcinogenesis: Why it should be dropped and replaced
    • Sonnenschein C., Soto A. M., 2000, "Somatic Mutation Theory of Carcinogenesis: Why it Should Be Dropped and Replaced", Molecular Carcinogenesis, 29: 205-211.
    • (2000) Molecular Carcinogenesis , vol.29 , pp. 205-211
    • Sonnenschein, C.1    Soto, A.M.2
  • 57
    • 11144226385 scopus 로고    scopus 로고
    • Are times a 'changin' in carcinogenesis?
    • Sonnenschein C., Soto A. M., 2005, "Are Times a 'Changin' in Carcinogenesis?", Endocrinology, 146: 11-12.
    • (2005) Endocrinology , vol.146 , pp. 11-12
    • Sonnenschein, C.1    Soto, A.M.2
  • 58
    • 33144464112 scopus 로고    scopus 로고
    • Carcinogenesis and metastasis now in the third dimension what's in it for pathologists?
    • Sonnenschein C., Soto A. M., 2006, "Carcinogenesis and Metastasis Now in the Third Dimension What's in it for Pathologists?", American Journal of Pathology, 168: 363-366.
    • (2006) American Journal of Pathology , vol.168 , pp. 363-366
    • Sonnenschein, C.1    Soto, A.M.2
  • 59
    • 48349090284 scopus 로고    scopus 로고
    • Theories of carcinogenesis: An emerging perspective
    • Sonnenschein C., Soto A. M., 2008, "Theories of Carcinogenesis: An Emerging Perspective", Seminars in Cancer Biology, 18: 372-377.
    • (2008) Seminars in Cancer Biology , vol.18 , pp. 372-377
    • Sonnenschein, C.1    Soto, A.M.2
  • 61
    • 7044264244 scopus 로고    scopus 로고
    • The somatic mutation theory of cancer: Growing problems with the paradigm?
    • Soto A. M., Sonnenschein C., 2004, "The Somatic Mutation Theory of Cancer: Growing Problems with the Paradigm?", BioEssays, 26: 1097-1107.
    • (2004) BioEssays , vol.26 , pp. 1097-1107
    • Soto, A.M.1    Sonnenschein, C.2
  • 62
    • 17644410052 scopus 로고    scopus 로고
    • Emergentism as a default: Cancer as a problem of tissue organization
    • Soto A. M., Sonnenschein C., 2005, "Emergentism as a Default: Cancer as a Problem of Tissue Organization", Journal of Biosciences, 30: 103-118.
    • (2005) Journal of Biosciences , vol.30 , pp. 103-118
    • Soto, A.M.1    Sonnenschein, C.2
  • 64
    • 17644365470 scopus 로고    scopus 로고
    • The end of 'naïve reductionism': Rise of systems biology or renaissance of physiology?
    • Strange K., 2004, "The End of 'Naïve Reductionism': Rise of Systems Biology or Renaissance of Physiology?", American Journal of Physiology-Cell Physiology, 288: 968-974.
    • (2004) American Journal of Physiology-Cell Physiology , vol.288 , pp. 968-974
    • Strange, K.1
  • 65
    • 0031092897 scopus 로고    scopus 로고
    • The coming kuhnian revolution in biology
    • Strohman R. C., 1997, "The Coming Kuhnian Revolution in Biology", Nature Biotechnology, 15: 194-200.
    • (1997) Nature Biotechnology , vol.15 , pp. 194-200
    • Strohman, R.C.1
  • 66
    • 0019947771 scopus 로고
    • Mechanism of activation of a human oncogene
    • Tabin C. J. 1982, "Mechanism of Activation of a Human Oncogene", Nature, 300: 143-149.
    • (1982) Nature , vol.300 , pp. 143-149
    • Tabin, C.J.1
  • 67
    • 34247541322 scopus 로고    scopus 로고
    • New insights into the pathogenesis of breast Cancer metastasis
    • Tarin D. et al., 2006, "New Insights into the Pathogenesis of Breast Cancer Metastasis", Breast Disease, 26: 13-25.
    • (2006) Breast Disease , vol.26 , pp. 13-25
    • Tarin, D.1
  • 68
    • 2542418082 scopus 로고    scopus 로고
    • Biological complexity emerges from the ashes of genetic reductionism
    • Van Regenmortel M. H., 2004, "Biological Complexity Emerges from the Ashes of Genetic Reductionism", Journal of Molecular Recognition, 17: 145-148.
    • (2004) Journal of Molecular Recognition , vol.17 , pp. 145-148
    • Van Regenmortel, M.H.1
  • 70
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., Kinzler K. W., 2004, "Cancer Genes and the Pathways they Control", Nature Medicine, 10: 789-799.
    • (2004) Nature Medicine , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 71
    • 0023929053 scopus 로고
    • The genetic origins of human cancer
    • Weinberg R. A., 1988, "The Genetic Origins of Human Cancer", Cancer, 61: 1963-1968.
    • (1988) Cancer , vol.61 , pp. 1963-1968
    • Weinberg, R.A.1
  • 73
    • 33846008439 scopus 로고    scopus 로고
    • Colorectal cancer: A model for epigenetic tumorigenesis
    • Wong J. J. L., Hawkins N. J., Ward R. L., 2007, "Colorectal Cancer: a Model for Epigenetic Tumorigenesis", Gut, 56: 140-148.
    • (2007) Gut , vol.56 , pp. 140-148
    • Wong, J.J.L.1    Hawkins, N.J.2    Ward, R.L.3


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