Sesquiterpene lactones of the plants Viguiera sylvatica and Decachaeta thieleana (Asteraceae) modulate nitric oxide production and phagocytosis of macrophages cell line RAW;Lactonas sesquiterpénicas de las plantas viguiera sylvatica y decachaeta thieleana (asteraceae) modulan la producción de óxido nítrico y la fagocitosis de macrófagos RAW

Revista de Biologia Tropical

Volumn 56, Issue 3, 2008, Pages 1063-1073

  Dupuy L, Omar A ^a,b   Murillo, Renato ^a   Bonilla, José A V ^a  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^b Facultad de Ciencias Naturales   (Costa Rica)

Author keywords

Asteraceae; Immunomodulation; Millerenolide; Sesquiterpene lactones; Thieleanin

Indexed keywords

ASTERACEAE; MURINAE; VIGUIERA;

LACTONE; MILLERENOLIDE; NITRIC OXIDE; SESQUITERPENE; THIELEANIN;

ANIMAL; ARTICLE; ASTERACEAE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; MACROPHAGE; MOUSE; PHAGOCYTOSIS; PHYSIOLOGY;

ANIMALS; ASTERACEAE; CELL LINE; LACTONES; MACROPHAGES; MICE; NITRIC OXIDE; PHAGOCYTOSIS; SESQUITERPENES;

EID: 70449725303     PISSN: 00347744     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Albina, J.E., C.D. Mills, W.L. Henry& M.D. Caldwell. 1989. Regulation of macrophage physiology by L-arginine: role of the oxidative L-arginine deiminase pathway. J. Immunol. 143: 3641-3646.
2. Bonilla, J.A., M.G. Mesén& W. Cartín. 1993. Modificación de un método colorimétrico que usa XTT, para la determinación de linfoproliferación. Rev. Cost. Cien. Med. 14: 25-31.
3. Bork, P.M., M.L. Schmitz, M. Kuhnt, C. Escher& M. Heinrich. 1997. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB. FEBS Lett. 402: 85-90.
4. Castro, V., P. Rüngeler, R. Murillo, E. Hernandez, G. Mora, H.L. Pahl& I. Merfort. 2000. Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. Phytochemistry 53: 257-263.
5. DeForge, L.E., J.C. Fantone, J.S. Kenney& D.G. Remick. 1992. Oxygen radical scavengers selectively inhibit interleukin-8 production in human whole blood. J. Clin. Invest. 90: 2123-2129.
6. García-Piñeres, A.J., V. Castro, G. Mora, T.J. Schmidt, E. Strunck, H.L. Pahl& I. Merfort. 2001. Cysteine 38 in p65/NF-kB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J. Biol. Chem. 276: 39713-39720.
7. Goode, H.F.& N.R. Webster. 1993. Free radicals and antioxidant in sepsis. Crit. Care Med. 21: 1770-1776.
8. Hagenlocker, B.E., B.A. Walker& P.A. Ward. 1990. Superoxide responses of immune complex-stimulated rat alveolar macrophages. Intracellular calcium and priming. J. Immunol. 144: 3898-3906.
9. Henson, P.M.& R.B. Johnston. 1987. Tissue injury in inflammation: oxidants, proteinases, and cationic proteins. J. Clin. Invest. 79: 669-674.
10. Hibbs, J.B., Z. Vavrin& R.R. Taintor. 1987. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J. Immunol. 138: 550-565.
11. Hibbs, J.B., R.R. Taintor, Z. Vavrin& E.M. Rachlin. 1988. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157: 87-94.
12. Hirvonen, M-R., B. Brüne& E.G. Lapetina. 1996. Heat shock proteins and macrophage resistance to the toxic effects of nitric oxide. Biochem. J. 315: 845-849.
13. Humar, M., A.J. García-Piñeres, V. Castro& I. Merfort. 2003. Effect of sesquiterpene lactones on the expression of the activation marker CD69 and of IL-2 in T-lymphocytes in whole blood. Biochem. Pharmacol. 65: 1551-1563.
14. Jensen, J.C., H.W. Pogrebniak, H.I. Pass, C. Buresh, M.J. Merino, D. Kauffman, D. Venzon, H.N. Langstein& J.A. Norton. 1992. Role of tumor necrosis factor in oxygen toxicity. J. Appl. Physiol. 72: 1902-1907.
15. Laskin, D.L.& K.J. Pendino. 1995. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 35: 655-677.
16. Lyß, G., T.J. Schmidt, I. Merfort& H.L. Pahl. 1997. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kB. Biol. Chem. 378: 951-961.
17. McKechnie, K., B.L. Furman& J.R. Parratt. 1986. Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats. Circ. Shock 19: 429-439.
18. Meier, B., H.H. Radeke, S. Delle, M. Younes, H. Sies, K. Resch& G.G. Habermehl. 1989. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumor necrosis factor-α. Biochem. J. 263: 539-545.
19. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63.
20. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 3051-3064.
21. Novelli, G.P., P. Angiolini, P. Livi& E. Paternostro. 1989. Oxygen-derived free radicals in the pathogenesis of experimental shock. Resuscitation 18: 195-205.
22. Peristeris, P., B.D. Clark, S. Gatti, R. Faggioni, A. Mantovani, M. Mengozzi, S.F. Orencole, M. Sironi& P. Ghezzi. 1992. N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production. Cell Immunol. 140: 390-399.
23. Rüngeler, P., V. Castro, G. Mora, N. Gören, W. Vischnewski, H.L. Pahl, I. Merfort& T.J. Schmidt. 1999. Inhibition of transcription factor NF-kB by sesquiterpene lactones: a proposed molecular mechanism of action. Bioorg. Med. Chem. 7: 2343-2352.
24. Siedle, B., L. Gustavsson, S. Johansson, R. Murillo, V. Castro, L. Bohlin& I. Merfort. 2003. The effect of sesquiterpene lactones on the release of human neutrophil elastase. Biochem. Pharmacol. 65: 897-903.
25. Stuehr, D.J.& M.A. Marletta. 1985. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. U.S.A. 82: 7738-7742.
26. Unanue, E.R. 1989. Macrophages, antigen-presenting cells, and the phenomena of antigen handling and presentation, p. 95-115. In W.E. Paul (ed.). Fundamental Immunology. Raven, Nueva York, EEUU.
27. Víctor, V.M., M. Miñano, N. Guayerbas, M. Del Río, S. Medina& M. De La Fuente. 1998. Effects of endotoxic shock in several functions of murine peritoneal macrophages. Mol. Cell Biochem. 189: 25-31.
28. Víctor, V.M., N. Guayerbas, M. Puerto, S. Medina& M. De La Fuente. 2000. Ascorbic acid modulates in vitro the function of macrophages from mice with endotoxic shock. Immunopharmacology 46: 89-101.
29. Víctor, V.M., D. Rubio& M. De La Fuente. 2002. Comparative study of several lymphocyte functions in two strains of mice with different models of endotoxic shock. Physiol. Res. 51: 291-298.
30. Víctor, V.M.& M. De La Fuente. 2003. Changes in the superoxide production and other macrophage functions could be related to the mortality of mice with endotoxin-induced oxidative stress. Physiol. Res. 52: 101-110.
31. Vischnewski, W., C.A. Skrochy, A.M. Nasi, C. Lopes& W. Herz. 1999. 15- Hydroxyeremantholide and derivatives from Eremanthus arboreus. Phytochemistry 50: 317-320.
32. Weiss, S.J. 1989. Tissue destruction by neutrophils. New Engl. J. Med. 320: 365-376.
33. Willuhn, G., P.M. Röttger& D. Wendisch. 1984. Helenalinund 11α13-dihydrohelenalinester aus Blüten von Arnica montana. Planta Med. 50: 35-37.
34. Wong, H.R.& I.Y. Menendez. 1999. Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells. Biochem. Biophys. Res. Cummun. 262: 375-380.
35. Yoshikawa, T., H. Takano, S. Takahashi, H. Ichikawa& M. Kondo. 1994. Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced multiple organ failure. Circ. Shock 42: 53-58.