High frequency of mitochondrial DNA D-loop mutations in Ewing's sarcoma

Biochemical and Biophysical Research Communications

Volumn 390, Issue 3, 2009, Pages 447-450

  Yu, Man ^a,b   Wan, Yanfang ^c   Zou, Qinghua ^d   Xi, Yanwei ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c TIANJIN MEDICAL UNIVERSITY   (China)

^d CHINA NATIONAL PETROLEUM CORPORATION   (China)

Author keywords

D loop; Ewing's sarcoma; Mitochondrial DNA; Mutation

Indexed keywords

MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; ARTICLE; CARCINOGENESIS; CHILD; CLINICAL ARTICLE; DNA DETERMINATION; DNA SEQUENCE; EWING SARCOMA; FEMALE; GENETIC POLYMORPHISM; HUMAN; MALE; PRIORITY JOURNAL; SOMATIC MUTATION;

ADOLESCENT; ADULT; BASE SEQUENCE; BONE NEOPLASMS; CHILD; CHILD, PRESCHOOL; DNA, MITOCHONDRIAL; FEMALE; GERM-LINE MUTATION; HUMANS; INFANT; MALE; NUCLEIC ACID CONFORMATION; SARCOMA, EWING'S; YOUNG ADULT;

EID: 70449718756     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.09.085     Document Type: Article

References (28)

1. Khoury J.D. Ewing sarcoma family of tumors. Adv. Anat. Pathol. 12 (2005) 212-220
2. Heare T., Hensley M.A., and Dell'Orfano S. Bone tumors: osteosarcoma and Ewing's sarcoma. Curr. Opin. Pediatr. 21 (2009) 365-372
3. Riggi N., and Stamenkovic I. The Biology of Ewing sarcoma. Cancer Lett. 254 (2007) 1-10
4. Delattre O., Zucman J., Melot T., Garau X.S., Zucker J.M., Lenoir G.M., Ambros P.F., Sheer D., Turc-Carel C., Triche T.J., et al. The Ewing family of tumors - a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl. J. Med. 331 (1994) 294-299
5. Ginsberg J.P., de Alava E., Ladanyi M., Wexler L.H., Kovar H., Paulussen M., Zoubek A., Dockhorn-Dworniczak B., Juergens H., Wunder J.S., Andrulis I.L., Malik R., Sorensen P.H., Womer R.B., and Barr F.G. EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. J. Clin. Oncol. 17 (1999) 1809-1814
6. Ludwig J.A. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr. Opin. Oncol. 20 (2008) 412-418
7. Chen X.J., and Butow R.A. The organization and inheritance of the mitochondrial genome. Nat. Rev. Genet. 6 (2005) 815-825
8. Moraes C.T. What regulates mitochondrial DNA copy number in animal cells?. Trends Genet. 17 (2001) 199-205
9. Singh K.K. Mitochondria damage checkpoint, aging, and cancer. Ann. NY Acad. Sci. 1067 (2006) 182-190
10. Lu J., Sharma L.K., and Bai Y. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell Res. 19 (2009) 802-815
11. Lee H.C., and Wei Y.H. Mitochondrial DNA instability and metabolic shift in human cancers. Int. J. Mol. Sci. 10 (2009) 674-701
12. Yu M., Shi Y., Wei X., Yang Y., Zhou Y., Hao X., Zhang N., and Niu R. Depletion of mitochondrial DNA by ethidium bromide treatment inhibits the proliferation and tumorigenesis of T47D human breast cancer cells. Toxicol. Lett. 170 (2007) 83-93
13. Bandelt H.J., Salas A., and Bravi C.M. What is a 'novel' mtDNA mutation - and does 'novelty' really matter?. J. Hum. Genet. 51 (2006) 1073-1082
14. Fang H., Lu J., Wei J., Shen L.J., Ding Z., Li H., and Bai Y. Mitochondrial DNA mutations in the D-loop region may not be frequent in cervical cancer: a discussion on pitfalls in mitochondrial DNA studies. J. Cancer Res. Clin. Oncol. 135 (2009) 649-651
15. Wei Y.H., and Lee H.C. Mitochondrial DNA mutations and oxidative stress in mitochondrial diseases. Adv. Clin. Chem. 37 (2003) 83-128
16. Guo X.G., and Guo Q.N. Mutations in the mitochondrial DNA D-Loop region occur frequently in human osteosarcoma. Cancer Lett. 239 (2006) 151-155
17. Graziewicz M.A., Day B.J., and Copeland W.C. The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acids Res. 30 (2002) 2817-2824
18. Mambo E., Gao X., Cohen Y., Guo Z., Talalay P., and Sidransky D. Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. Proc. Natl. Acad. Sci. USA 100 (2003) 1838-1843
19. Clayton D.A. Transcription and replication of mitochondrial DNA. Hum. Reprod. 15 Suppl. 2 (2000) 11-17
20. Higuchi M. Regulation of mitochondrial DNA content and cancer. Mitochondrion 7 (2007) 53-57
21. Yu M., Zhou Y., Shi Y., Ning L., Yang Y., Wei X., Zhang N., Hao X., and Niu R. Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life 59 (2007) 450-457
22. Lee H.C., Li S.H., Lin J.C., Wu C.C., Yeh D.C., and Wei Y.H. Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutat. Res. 547 (2004) 71-78
23. Chinnery P.F., Samuels D.C., Elson J., and Turnbull D.M. Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?. Lancet 360 (2002) 1323-1325
24. Bandy B., and Davison A.J. Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?. Free Radic. Biol. Med. 8 (1990) 523-539
25. n dinucleotide repeat polymorphism with breast cancer risk and survival among Chinese women. Cancer Epidemiol. Biomarkers Prev. 17 (2008) 2117-2122
26. Singh K.K., and Kulawiec M. Mitochondrial DNA polymorphism and risk of cancer. Methods Mol. Biol. 471 (2009) 291-303
27. Liu V.W., Wang Y., Yang H.J., Tsang P.C., Ng T.Y., Wong L.C., Nagley P., and Ngan H.Y. Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer. Hum. Mutat. 22 (2003) 173-174
28. Covarrubias D., Bai R.K., Wong L.J., and Leal S.M. Mitochondrial DNA variant interactions modify breast cancer risk. J. Hum. Genet. 53 (2008) 924-928