Sulthiame in the Primary Therapy of West Syndrome: A Randomized Double-blind Placebo-controlled Add-on Trial on Baseline Pyridoxine Medication

Epilepsia

Volumn 45, Issue 2, 2004, Pages 103-108

  Debus, Otfried Martin ^a   Kurlemann, Gerhard ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Infantile spasms; Placebo controlled trial; Pyridoxine; Sulthiame; West syndrome

Indexed keywords

ANTICONVULSIVE AGENT; PLACEBO; PYRIDOXINE; SULTIAME; THIAZINE DERIVATIVE;

ABDOMINAL PAIN; ADD ON THERAPY; ANOREXIA; ANTICONVULSANT THERAPY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; INFANT; INFANTILE SPASM; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; SOMNOLENCE; TREATMENT OUTCOME; TUBEROUS SCLEROSIS; VOMITING; WEST SYNDROME;

ANTICONVULSANTS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FOLLOW-UP STUDIES; HUMANS; INFANT; PLACEBOS; PYRIDOXINE; SPASMS, INFANTILE; THIAZINES; TREATMENT OUTCOME;

EID: 0842333061     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0013-9580.2004.19003.x     Document Type: Article

References (23)

1. West WJ. On a peculiar form of infantile convulsions. Lancet 1841;i:724-5.
2. Osborne JP, Lux A. Towards an international consensus on definitions and standardised outcome measures for therapeutic trials (and epidemiological studies) in West syndrome. Brain Dev 2001;23:677-82.
3. Hancock E, Osborne JP, Milner P. The treatment of West syndrome: a Cochrane review of the literature to December 2000. Brain Dev 2001;23:624-34.
4. Riikonen R, Donner M. ACTH therapy in infantile spasms: side effects. Arch Dis Child 1980;55:664-72.
5. Appleton RE, Peters AC, Mumford JP, et al. Randomized, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms. Epilepsia 1999;40:1627-33.
6. 6. Epilepsia 1993;34:757-63.
7. Baxter P. Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK. Arch Dis Child 1999;81:431-3.
8. 6-responsive West syndrome. Pediatr Neurol 2000;23:202-6.
9. Watanabe K. Medical treatment of West syndrome in Japan. J Child Neurol 1995;10:143-7.
10. Siemes H, Burgeois BFD. Epilepsie mit Blitz-, Nick und Salaam-Krämpfen. In: Siemes H, Burgeois BFD, eds. Anfälle und epilepsien bei kindern undjugendlichen. Stuttgart: Georg Thieme Verlag, 2001;13:5-41.
11. Baxter P. Pyridoxine-dependent and pyridoxine-responsive seizures. Dev Med Child Neurol 2001;43:416-20.
12. Rating D, Wolf C, Bast T. Sulthiame as monotherapy in children with benign childhood epilepsy with centrotemporal spikes: a six-month randomized, double-blind, placebo-controlled study. Epilepsia 2000;41:1284-8.
13. Debus OM, Köhring J, Fiedler B, et al. Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study. Seizure 2002;11:381-3.
14. Hrachovy RA, Glaze DG, Frost JD. A retrospective study of spontaneous remission and long term outcome in patients with infantile spasms. Epilepsia 1991;32:212-4.
15. Hrachovy RA, Frost JD Jr, Kellaway P. Hypsarrhythmia: variations on a theme. Epilepsia 1982;25:317-25.
16. Jeavons PM, Livet MO. West syndrome: infantile spasms. In: Roger J, Bureau M, Dravet C et al., eds. Epileptic syndromes in infancy, childhood and adolescence. London: John Libbey, 1992:53-6.
17. Watanabe K, Negoro T, Okumura A. Symptomatology of infantile spasms. Brain Dev 2001;23:453-66.
18. Ohtsuka Y, Matsuda M, Ogino T, et al. Treatment of the West syndrome with high-dose pyridoxal phosphate. Brain Dev 1987;9:418-21.
19. 6 treatment in infantile spasms. Neuropediatrics 1986;17:7-10.
20. Heiskala H, Riikonen R, Santavouri P, et al. West syndrome: individualized ACTH therapy. Brain Dev 1996;18:456-60.
21. Mackay M, Weiss S, Snead OC III. Treatment of infantile spasms: an evidence based approach. Int Rev Neurobiol 2002;49:157-84.
22. Bisulli F, Volpi L, Meletti S, et al. Ictal pattern of EEG and muscular activation in symptomatic infantile spasms: a videopolygraphic and computer analysis. Epilepsia 2002;43:1559-63.
23. 6 treatment in West syndrome. Brain Dev 2001;23:654-7.