Gene expression changes in an animal model of in utero irradiation-induced cortical dysplasia

Epileptic Disorders

Volumn 11, Issue 3, 2009, Pages 232-243

  Hiremath, Girish K ^a   Tilelli, Cristiane Q ^a   Xu, Yaomin ^a   Gopalan, Banu ^a   Najm, Imad M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Animal model; Cortical dysplasia; Gene; In utero radiation; Microarray

Indexed keywords

AMPA RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; GLUTAMIC ACID; PEROXIREDOXIN; PROTEIN KINASE C ALPHA; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; CORTICAL DYSPLASIA; DENDRITIC CELL; DOWN REGULATION; EPILEPSY; EXCITOTOXICITY; GENE EXPRESSION; GENETIC ANALYSIS; HIPPOCAMPUS; HISTOPATHOLOGY; IRRADIATION; MICROARRAY ANALYSIS; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PERINATAL PERIOD; PRIORITY JOURNAL; PROGENY; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; CELL DIVISION; CELL SURVIVAL; CEREBRAL CORTEX; ELECTROENCEPHALOGRAPHY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; NEURITES; NEUROTRANSMITTER AGENTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROTRANSMITTER; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION;

EID: 70449672927     PISSN: 12949361     EISSN: 19506945     Source Type: Journal    
DOI: 10.1684/epd.2009.0270     Document Type: Article

References (60)

1. Baraban SC, Schwartzkroin PA. Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment. Epilepsy Res 1995; 22: 145-156
2. Bautista JF, Foldvary-Schaefer N, Bingaman WE. Focal cortical dysplasia and intractable epilepsy in adults: clinical, EEG, imaging, and surgical features. Epilepsy Res 2003; 55: 131-136 (Pubitemid 37011377)
3. Becker AJ, Urbach H, Scheffler B. Focal cortical dysplasia of Taylor's balloon cell type: mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis. Annals of Neurology 2002a ; 52 : 29-37 (Pubitemid 34693740)
4. Becker AJ, Wiestler OD, Blumcke I. Functional genomics in experimental and human temporal lobe epilepsy: powerful new tools to identify molecular disease mechanisms of hippocampal damage. Progress in Brain Research 2002b ; 135 : 161-173 (Pubitemid 35461015)
5. Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003; 19: 185-193 (Pubitemid 36181903)
6. Bradham DM, Igarashi A, Potter RL, Grotendorst GR. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 1991; 114: 1285-1294 (Pubitemid 21909886)
7. Brecht S, Schwarze K, Waetzig V, et al. Changes in peptidylprolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain. Neuroscience 2003; 120: 1037-1048 (Pubitemid 36966654)
8. Brigstock DR. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocrine Rev 1999; 20: 189-206.
9. Davis KE, Straff DJ, Weinstein EA, et al. Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. J Neurosci 1998; 18: 2475-2485
10. Demuth T, Rennert JL, Hoelzinger DB, et al. Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines. BMC Genomics 2008; 9: 54.
11. Dunning MJ, Barbosa-Morais NL, Lynch AG, et al. Statistical issues in the analysis of Illumina data. BMC Bioinformatics 2008; 9: 85.
12. Ehlers MD. Molecular morphogens for dendritic spines. Trends Neurosci 2002; 25: 64-67
13. Ginsberg SD, Hemby SE, Lee VM, Eberwine JH, Trojanowski JQ. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann Neurol 2000; 48: 77-87.
14. González MI, Kazanietz MG, Robinson MB. Regulation of the neuronal glutamate transporter excitatory amino acid carrier-1 (EAAC1) by different protein kinase C subtypes. Mol Pharmacol 2002; 62: 901-910
15. González MI, Susarla BT, Robinson MB. Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1. J Neurochem 2005; 94: 1180-1188
16. Gonzalez-Martinez JA, Srikijvilaikul T, Nair D, Bingaman WE. Long-term seizure outcome in reoperation after failure of epilepsy surgery. Neurosurgery 2007; 60: 873-880 (Pubitemid 46684271)
17. Hirabayashi S, Binnie CD, Janota I, Polkey CE. Surgical treatment of epilepsy due to cortical dysplasia: clinical and EEG findings. Journal of Neurology, Neurosurgery & Psychiatry 1993; 56: 765-770 (Pubitemid 23232536)
18. Ichtchenko K, Bittner MA, Krasnoperov V, et al. A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. J Biol Chem 1999; 274: 5491-5498 (Pubitemid 29109196)
19. Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem 1998; 273: 6297-6302 (Pubitemid 28144719)
20. Kellinghaus C, Kunieda T, Ying Z, Pan A, Lüders HO, Najm I. Severity of histopathologic abnormalities and in vivo epileptogenicity in the in utero radiation model of rats is dose dependent. Epilepsia 2004; 45: 583-591 (Pubitemid 38802204)
21. Kim SK, Wang KC, Hong SJ, et al. Gene expression profile analyses of cortical dysplasia by cDNA arrays. Epilepsy Research 2003; 56: 175-183 (Pubitemid 37464930)
22. Kinnula VL, Crapo JD. Superoxide dismutases in malignant cells and human tumors. Free Radic Biol Med 2004; i6: 718-744 (Pubitemid 38264416)
23. Kloss S, Pieper T, Pannek H, Holthausen H, Tuxhorn I. Epilepsy surgery in children with focal cortical dysplasia (FCD): results of long-term seizure outcome. Neuropediatrics 2002; 33: 21-26 (Pubitemid 34273033)
24. Kondo S, Najm I, Kunieda T, et al. In vivo spontaneous epileptogenicity in the rat model of radiation-induced cortical dysplasia. Epilepsia 2001; 42: 1221-1227
25. Kyin R, Hua Y, Baybis M, et al. Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex. Am J Pathol 2001; 159: 1541-1554 (Pubitemid 32947982)
26. Lee SH, Simonetta A, Sheng M. Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. Neuron 2004; 43: 221-236 (Pubitemid 38942962)
27. Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA. Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcoholism Clin Exp Res 2000; 24: 1873-1882 (Pubitemid 32001860)
28. Ljungberg MC, Bhattacharjee MB, Lu Y, et al. Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ann Neurol 2006; 60: 420-429 (Pubitemid 44684978)
29. Marín-Vicente C, Nicolás FE, Gómez-Fernández JC, Corbalán-García S. The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells. J Mol Biol 2008; 377: 1038-1052
30. Mikuni N, Babb TL, Ying Z, et al. NMDA-receptors 1 and 2A/B coassembly increased in human epileptic focal cortical dysplasia. Epilepsia 1999; 40: 1683-1687
31. Mirnics K, Middleton FA, Marquez A, Lewis D, Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 2000; 28: 53-67.
32. Möddel G, Jacobson B, Ying Z, et al. The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. Brain Res 2005; 1046: 10-23. (Pubitemid 40775869)
33. Najm I, Ying Z, Babb T, Crino PB, et al. Mechanisms of epileptogenicity in cortical dysplasias. Neurology 2004; 62 (6 Suppl. 3): S9.
34. Najm IM, Ying Z, Babb T, et al. Epileptogenicity correlated with increased N-methyl-D-aspartate receptor subunit NR2A/B in human focal cortical dysplasia. Epilepsia 2000; 41: 971-976 (Pubitemid 30640861)
35. Nordfors K, Haapasalo J, Helén P, et al. Peroxiredoxins and antioxidant enzymes in pilocytic astrocytomas. Clin Neuropathol 2007; 26: 210-218 (Pubitemid 47403415)
36. Oghlakian RO, Tilelli CQ, Hiremath GK, Alexopoulos AV, Najm IM. Single injection of a low dose of pentylenetetrazole leads to epileptogenesis in an animal model of cortical dysplasia. Epilepsia 2009; 50: 801-810
37. Palmini A, Andermann F, Olivier A, Tampieri D, Robitaille Y. Focal neuronal migration disorders and intractable partial epilepsy: results of surgical treatment. Annals of Neurology 1991; 30: 750-757
38. Palmini A, Gambardella A, Andermann F, et al. Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results. Annals of Neurology 1995; 37: 476-487
39. Palmini A, Najm I, Avanzini G, Babb T, et al. Terminology and classification of the cortical dysplasias. Neurology 2004; 62 (6 Suppl. 3): S2-8.
40. Pan LH, Beppu T, Kurose A, et al. Neoplastic cells and proliferating endothelial cells express connective tissue growth factor (CTGF) in glioblastoma. Neurol Res 2002; 24: 677-683
41. Park P, Taylor MD, Mainprize TG, et al. Transcriptional profiling of medulloblastoma in children. J Neurosurg 2003; 99: 534-541
42. Qu D, Rashidian J, Mount MP, et al. Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron 2007; 55: 37-52. (Pubitemid 46990825)
43. Quitsch A, Berhörster K, Liew CW, Richter D, Kreienkamp HJ. Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180. J Neurosci 2005; 25: 479-487 (Pubitemid 40105619)
44. Prayson RA, Estes ML. Cortical dysplasia: a histopathologic study of 52 cases of partial lobectomy in patients with epilepsy. Human Pathology 1995; 26: 493-500.
45. Raymond AA, Fish DR, Sisodiya SM, Alsanjari N, Stevens JM, Shorvon SD. Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients. Brain 1995; 118: 629-660
46. Rich JN, Hans C, Jones B, et al. Gene expression profiling and genetic markers in glioblastoma survival. Cancer Res 2005; 65: 4051-4058 (Pubitemid 40775641)
47. Rickert CH. Cortical dysplasia: neuropathological aspects. Child's Nervous System 2006; 22: 821-826
48. Roper SN, Gilmore RL, Houser CR. Experimentally induced disorders of neuronal migration produce an increased propensity for electrographic seizures in rats. Epilepsy Research 1995; 21: 205-219
49. Rorive S, Maris C, Debeir O, et al. Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles. J Neuropath Exp Neurol 2006; 65: 794-807. (Pubitemid 44200320)
50. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 1991; 10: 2247-2258 (Pubitemid 21905698)
51. Shi L, Reid LH, Jones WD, et al. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nature Biotech 2006; 24: 1151-1161 (Pubitemid 44359727)
52. Siegel AM, Cascino GD, Meyer FB, Marsh WR, Scheithauer BW, Sharbrough FW. Surgical outcome and predictive factors in adult patients with intractable epilepsy and focal cortical dysplasia. Acta Neurol Scand 1996; 113: 65-71.
53. Smyth GK. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical Applications in Genetics and Molecular Biology 2004; 3:: 1 Article 3.
54. Steiner P, Sarria JC, Glauser L, Magnin S, Catsicas S, Hirling H. Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD. J Cell Biol 2002; 157: 1197-1209 (Pubitemid 34847790)
55. Suzuki T, Maruno M, Wada K, et al. Genetic analysis of human glioblastomas using a genomic microarray system. Brain Tumor Path 2004; 21: 27-34. (Pubitemid 38915180)
56. Taylor JP, Sater R, French J, Baltuch G, Crino PB. Transcription of intermediate filament genes is enhanced in focal cortical dysplasia. Acta Neuropathol 2001; 102: 141-148 (Pubitemid 32771661)
57. van den Boom J, Wolter M, Kuick R, et al. Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Path 2003; 163: 1033-1043 (Pubitemid 37040139)
58. Whitney LW, Becker KG, Tresser NJ, et al. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann Neurol 1999; 46: 425-428 (Pubitemid 29416284)
59. Widdess-Walsh P, Jeha L, Nair D, Kotagal P, Bingaman W, Najm I. Subdural electrode analysis in focal cortical dysplasia: predictors of surgical outcome. Neurology 2007; 69: 660-667 (Pubitemid 47256008)
60. Ying Z, Babb TL, Mikuni N, Najm I, Drazba J, Bingaman W. Selective coexpression of NMDAR2A/B and NMDAR1 subunit proteins in dysplastic neurons of human epileptic cortex. Exp Neurol 1999; 159: 409-418 (Pubitemid 29485227)