Neurologic Manifestations of Transplant Complications

Neurologic Clinics

Volumn 28, Issue 1, 2010, Pages 235-251

  Živković, Saša A ^a,b   Abdel Hamid, Hoda ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Neurotoxicity; Opportunistic infections; Posttransplant recovery; Transplant complications

Indexed keywords

ACICLOVIR; ANTIDEPRESSANT AGENT; ANTIINFECTIVE AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BORTEZOMIB; BUSULFAN; CALCINEURIN INHIBITOR; CEPHALOSPORIN DERIVATIVE; COLCHICINE; CORTICOSTEROID; CYCLOSPORIN; ETIRACETAM; EVEROLIMUS; GABAPENTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMIPENEM; IMMUNOSUPPRESSIVE AGENT; LINEZOLID; MYCOPHENOLIC ACID; NARCOTIC ANALGESIC AGENT; NEUROLEPTIC AGENT; OKT 3; PHENYTOIN; RAPAMYCIN; SEROTONIN UPTAKE INHIBITOR; TACROLIMUS; THALIDOMIDE; THYMOCYTE ANTIBODY; UNINDEXED DRUG;

ASEPTIC MENINGITIS; ATAXIA; BEHAVIOR DISORDER; BRAIN DISEASE; CEREBROVASCULAR DISEASE; COMPLEX REGIONAL PAIN SYNDROME; CONFUSION; CONSCIOUSNESS DISORDER; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG COMPETITION; DRUG INDUCED HEADACHE; DRUG METABOLISM; DRUG RESPONSE; DYSTHYMIA; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT REJECTION; HEADACHE; HEART TRANSPLANTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HYPERAMMONEMIA; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LIPOMATOSIS; LIVER FAILURE; LIVER TRANSPLANTATION; LONG TERM CARE; MAINTENANCE THERAPY; MENTAL DISEASE; METABOLIC ENCEPHALOPATHY; MOTOR DYSFUNCTION; MYOCLONUS; MYOPATHY; NEUROLOGIC DISEASE; NEUROTOXICITY; OPPORTUNISTIC INFECTION; OPTIC NERVE DISEASE; PANCREAS TRANSPLANTATION; PARKINSONISM; PERIPHERAL NEUROPATHY; PLASMAPHERESIS; POLYNEUROPATHY; POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; RHABDOMYOLYSIS; SEIZURE; SEROTONIN SYNDROME; SPINAL CORD DISEASE; SURGICAL TECHNIQUE; TARDIVE DYSKINESIA; TRANSPLANTATION; TREMOR; VISUAL DISORDER;

ADULT; CHILD; HUMANS; IMMUNOSUPPRESSIVE AGENTS; NERVOUS SYSTEM DISEASES; TRANSPLANTATION;

EID: 70449647099     PISSN: 07338619     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ncl.2009.09.011     Document Type: Review

References (97)

1. Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, US Department of Health and Human Services. 2008 Annual Report of the US Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1998-2007. Rockville, MD; United Network for Organ Sharing, Richmond, VA; University Renal Research and Education Association, Ann Arbor (MI), 2009.
2. Pasquini M.C., Wang Z., and Schneider L. Current use and outcome of hematopoietic stem cell transplantation. CIBMTR Newsletter 13 2 (2007) 5-8
3. Wong M., Mallory Jr. G.B., Goldstein J., et al. Neurologic complications of pediatric lung transplantation. Neurology 53 7 (1999) 1542-1549
4. Bronster D.J., Emre S., Boccagni P., et al. Central nervous system complications in liver transplant recipients-incidence, timing, and long-term follow-up. Clin Transplant 14 1 (2000) 1-7
5. Faraci M., Lanino E., Dini G., et al. Severe neurologic complications after hematopoietic stem cell transplantation in children. Neurology 59 12 (2002) 1895-1904
6. Mayer T.O., Biller J., O'Donnell J., et al. Contrasting the neurologic complications of cardiac transplantation in adults and children. J Child Neurol 17 3 (2002) 195-199
7. Lewis M.B., and Howdle P.D. Neurologic complications of liver transplantation in adults. Neurology 61 9 (2003) 1174-1178
8. Zivkovic S., Abu-Elmagd K., Bond G., et al. Long-term follow-up of neurologic complications of multivisceral and intestinal transplantation. Neurology 64 Suppl 1 (2005) A123
9. Denier C., Bourhis J.H., Lacroix C., et al. Spectrum and prognosis of neurologic complications after hematopoietic transplantation. Neurology 67 11 (2006) 1990-1997
10. Erol I., Alehan F., Ozcay F., et al. Neurological complications of liver transplantation in pediatric patients: a single center experience. Pediatr Transplant 11 2 (2007) 152-159
11. Zierer A., Melby S.J., Voeller R.K., et al. Significance of neurologic complications in the modern era of cardiac transplantation. Ann Thorac Surg 83 5 (2007) 1684-1690
12. Zivkovic S.A., Jumaa M., Barisic N., et al. Neurologic complications following lung transplantation. J Neurol Sci 280 1-2 (2009) 90-93
13. Patchell R.A. Neurological complications of organ transplantation. Ann Neurol 36 5 (1994) 688-703
14. Pless M., and Zivkovic S.A. Neurologic complications of transplantation. Neurologist 8 2 (2002) 107-120
15. DiMartini A., Fontes P., Dew M.A., et al. Age, model for end-stage liver disease score, and organ functioning predict posttransplant tacrolimus neurotoxicity. Liver Transpl 14 6 (2008) 815-822
16. Menegaux F., Keeffe E.B., Andrews B.T., et al. Neurological complications of liver transplantation in adult versus pediatric patients. Transplantation 58 4 (1994) 447-450
17. Wijdicks E.F. Impaired consciousness after liver transplantation. Liver Transpl Surg 1 5 (1995) 329-334
18. Buis C.I., Wiesner R.H., Krom R.A., et al. Acute confusional state following liver transplantation for alcoholic liver disease. Neurology 59 4 (2002) 601-605
19. Estol C.J., Faris A.A., Martinez A.J., et al. Central pontine myelinolysis after liver transplantation. Neurology 39 4 (1989) 493-498
20. Bleggi-Torres L.F., de Medeiros B.C., Ogasawara V.S., et al. Iatrogenic Wernicke's encephalopathy in allogeneic bone marrow transplantation: a study of eight cases. Bone Marrow Transplant 20 5 (1997) 391-395
21. Eidelman B.H., Abu-Elmagd K., Wilson J., et al. Neurologic complications of FK 506. Transplant Proc 23 6 (1991) 3175-3178
22. Wijdicks E.F., Wiesner R.H., Dahlke L.J., et al. FK506-induced neurotoxicity in liver transplantation. Ann Neurol 35 4 (1994) 498-501
23. Wijdicks E.F., Wiesner R.H., and Krom R.A. Neurotoxicity in liver transplant recipients with cyclosporine immunosuppression. Neurology 45 11 (1995) 1962-1964
24. Small S.L., Fukui M.B., Bramblett G.T., et al. Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506). Ann Neurol 40 4 (1996) 575-580
25. DeBellis R.J., Schaefer O.P., Liquori M., et al. Linezolid-associated serotonin syndrome after concomitant treatment with citalopram and mirtazepine in a critically ill bone marrow transplant recipient. J Intensive Care Med 20 6 (2005) 351-353
26. Abbott K.C., Agodoa L.Y., and O'Malley P.G. Hospitalized psychoses after renal transplantation in the United States: incidence, risk factors, and prognosis. J Am Soc Nephrol 14 6 (2003) 1628-1635
27. Dew M.A., and DiMartini A.F. Psychological disorders and distress after adult cardiothoracic transplantation. J Cardiovasc Nurs 20 Suppl 5 (2005) S51-S66
28. Krahn L.E., and DiMartini A. Psychiatric and psychosocial aspects of liver transplantation. Liver Transpl 11 10 (2005) 1157-1168
29. Corruble E., Buhl C., Esposito D., et al. Psychosis associated with elevated trough tacrolimus blood concentrations after combined kidney-pancreas transplant. Int J Neuropsychopharmacol 9 4 (2006) 493-494
30. Warrington T.P., and Bostwick J.M. Psychiatric adverse effects of corticosteroids. Mayo Clin Proc 81 10 (2006) 1361-1367
31. DiMartini A., Dew M.A., Kormos R., et al. Posttraumatic stress disorder caused by hallucinations and delusions experienced in delirium. Psychosomatics 48 5 (2007) 436-439
32. Medici V., Mirante V.G., Fassati L.R., et al. Liver transplantation for Wilson's disease: the burden of neurological and psychiatric disorders. Liver Transpl 11 9 (2005) 1056-1063
33. Wijdicks E.F. Neurotoxicity of immunosuppressive drugs. Liver Transpl 7 11 (2001) 937-942
34. Stracciari A., Guarino M., Pazzaglia P., et al. Acquired hepatocerebral degeneration: full recovery after liver transplantation. J Neurol Neurosurg Psychiatr 70 1 (2001) 136-137
35. Pavletic Z.S., Bishop M.R., Markopoulou K., et al. Drug-induced parkinsonism after allogeneic bone marrow transplantation. Bone Marrow Transplant 17 6 (1996) 1185-1187
36. Lentine K.L., Rocca Rey L.A., Kolli S., et al. Variations in the risk for cerebrovascular events after kidney transplant compared with experience on the waiting list and after graft failure. Clin J Am Soc Nephrol 3 4 (2008) 1090-1101
37. Estol C.J., Pessin M.S., and Martinez A.J. Cerebrovascular complications after orthotopic liver transplantation: a clinicopathologic study. Neurology 41 6 (1991) 815-819
38. Coplin W.M., Cochran M.S., Levine S.R., et al. Stroke after bone marrow transplantation: frequency, aetiology and outcome. Brain 124 Pt 5 (2001) 1043-1051
39. Wijdicks E.F., Torres V.E., Schievink W.I., et al. Cerebral hemorrhage in recipients of renal transplantation. Mayo Clin Proc 74 11 (1999) 1111-1112
40. Wijdicks E.F., de Groen P.C., Wiesner R.H., et al. Intracerebral hemorrhage in liver transplant recipients. Mayo Clin Proc 70 5 (1995) 443-446
41. Pomeranz S., Naparstek E., Ashkenazi E., et al. Intracranial haematomas following bone marrow transplantation. J Neurol 241 4 (1994) 252-256
42. Trimarchi H.M., Truong L.D., Brennan S., et al. FK506-associated thrombotic microangiopathy: report of two cases and review of the literature. Transplantation 67 4 (1999) 539-544
43. Gordon B.G., Haire W.D., Patton D.F., et al. Thrombotic complications of BMT: association with protein C deficiency. Bone Marrow Transplant 11 1 (1993) 61-65
44. Estol C.J., Lopez O., Brenner R.P., et al. Seizures after liver transplantation: a clinicopathologic study. Neurology 39 10 (1989) 1297-1301
45. Wijdicks E.F., Plevak D.J., Wiesner R.H., et al. Causes and outcome of seizures in liver transplant recipients. Neurology 47 6 (1996) 1523-1525
46. Steg R.E., Kessinger A., and Wszolek Z.K. Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation. Bone Marrow Transplant 23 9 (1999) 959-962
47. Zampella E.J., Duvall E.R., Sekar B.C., et al. Symptomatic spinal epidural lipomatosis as a complication of steroid immunosuppression in cardiac transplant patients. Report of two cases. J Neurosurg 67 5 (1987) 760-764
48. Gruhn B., Meerbach A., Egerer R., et al. Successful treatment of Epstein-Barr virus-induced transverse myelitis with ganciclovir and cytomegalovirus hyperimmune globulin following unrelated bone marrow transplantation. Bone Marrow Transplant 24 12 (1999) 1355-1358
49. Zarranz J.J., Rouco I., Gomez-Esteban J.C., et al. Human T lymphotropic virus type I (HTLV-1) associated myelopathy acquired through a liver transplant. J Neurol Neurosurg Psychiatr 71 6 (2001) 818
50. Schwartz D.L., Schechter G.P., Seltzer S., et al. Radiation myelitis following allogeneic stem cell transplantation and consolidation radiotherapy for non-Hodgkin's lymphoma. Bone Marrow Transplant 26 12 (2000) 1355-1359
51. Hermans G., De Jonghe B., Bruyninckx F., et al. Clinical review: critical illness polyneuropathy and myopathy. Crit Care 12 6 (2008) 238
52. Campellone J.V., Lacomis D., Kramer D.J., et al. Acute myopathy after liver transplantation. Neurology 50 1 (1998) 46-53
53. Guarneri B., Bertolini G., and Latronico N. Long-term outcome in patients with critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study. J Neurol Neurosurg Psychiatr 79 7 (2008) 838-841
54. Dyck P.J., Velosa J.A., Pach J.M., et al. Increased weakness after pancreas and kidney transplantation. Transplantation 72 8 (2001) 1403-1408
55. Hermans G., Wilmer A., Meersseman W., et al. Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med 175 5 (2007) 480-489
56. Maziak D.E., Maurer J.R., and Kesten S. Diaphragmatic paralysis: a complication of lung transplantation. Ann Thorac Surg 61 1 (1996) 170-173
57. Stevens A.M., Sullivan K.M., and Nelson J.L. Polymyositis as a manifestation of chronic graft-versus-host disease. Rheumatology (Oxford) 42 1 (2003) 34-39
58. Wilson J.R., Conwit R.A., Eidelman B.H., et al. Sensorimotor neuropathy resembling CIDP in patients receiving FK506. Muscle Nerve 17 5 (1994) 528-532
59. Steiger M.J., Farrah T., Rolles K., et al. Cyclosporin associated headache. J Neurol Neurosurg Psychiatr 57 10 (1994) 1258-1259
60. Sila C.A. Spectrum of neurologic events following cardiac transplantation. Stroke 20 11 (1989) 1586-1589
61. Gourishankar S., McDermid J.C., Jhangri G.S., et al. Herpes zoster infection following solid organ transplantation: incidence, risk factors and outcomes in the current immunosuppressive era. Am J Transplant 4 1 (2004) 108-115
62. Grotz W.H., Breitenfeldt M.K., Braune S.W., et al. Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. Transpl Int 14 1 (2001) 16-23
63. Collini A., De Bartolomeis C., Barni R., et al. Calcineurin-inhibitor induced pain syndrome after organ transplantation. Kidney Int 70 7 (2006) 1367-1370
64. Papanicolaou G.A., Meyers B.R., Fuchs W.S., et al. Infectious ocular complications in orthotopic liver transplant patients. Clin Infect Dis 24 6 (1997) 1172-1177
65. Brazis P.W., Spivey J.R., Bolling J.P., et al. A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation. Am J Ophthalmol 129 4 (2000) 536-538
66. van de Beek D., Patel R., Daly R.C., et al. Central nervous system infections in heart transplant recipients. Arch Neurol 64 12 (2007) 1715-1720
67. Fishman J.A. Infection in solid-organ transplant recipients. N Engl J Med 357 25 (2007) 2601-2614
68. Martin-Davila P., Fortun J., Lopez-Velez R., et al. Transmission of tropical and geographically restricted infections during solid-organ transplantation. Clin Microbiol Rev 21 1 (2008) 60-96
69. Singh N., and Husain S. Infections of the central nervous system in transplant recipients. Transpl Infect Dis 2 3 (2000) 101-111
70. Finelli P.F., and Uphoff D.F. Magnetic resonance imaging abnormalities with septic encephalopathy. J Neurol Neurosurg Psychiatr 75 8 (2004) 1189-1191
71. Seeley W.W., Marty F.M., Holmes T.M., et al. Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology 69 2 (2007) 156-165
72. Shitrit D., Lev N., Bar-Gil-Shitrit A., et al. Progressive multifocal leukoencephalopathy in transplant recipients. Transpl Int 17 11 (2005) 658-665
73. DeSalvo D., Roy-Chaudhury P., Peddi R., et al. West Nile virus encephalitis in organ transplant recipients: another high-risk group for meningoencephalitis and death. Transplantation 77 3 (2004) 466-469
74. Derouin F., and Pelloux H. Prevention of toxoplasmosis in transplant patients. Clin Microbiol Infect 14 12 (2008) 1089-1101
75. Mendez O., Kanal E., Abu-Elmagd K.M., et al. Granulomatous amebic encephalitis in a multivisceral transplant recipient. Eur J Neurol 13 3 (2006) 292-295
76. Pittock S.J., Rabinstein A.A., Edwards B.S., et al. OKT3 neurotoxicity presenting as akinetic mutism. Transplantation 75 7 (2003) 1058-1060
77. Bodkin C.L., and Eidelman B.H. Sirolimus-induced posterior reversible encephalopathy. Neurology 68 23 (2007) 2039-2040
78. Singhal S., Powles R., Treleaven J., et al. Central nervous system relapse after bone marrow transplantation for acute leukemia in first remission. Bone Marrow Transplant 17 4 (1996) 637-641
79. Buell J.F., Gross T.G., Hanaway M.J., et al. Posttransplant lymphoproliferative disorder: significance of central nervous system involvement. Transplant Proc 37 2 (2005) 954-955
80. Schiff D. Gliomas following organ transplantation: analysis of the contents of a tumor registry. J Neurosurg 101 6 (2004) 932-934
81. Shemesh E., Shneider B.L., Savitzky J.K., et al. Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 113 4 (2004) 825-832
82. Alonso E.M. Growth and developmental considerations in pediatric liver transplantation. Liver Transpl 14 5 (2008) 585-591
83. Fonseca-Aten M., and Michaels M.G. Infections in pediatric solid organ transplant recipients. Semin Pediatr Surg 15 3 (2006) 153-161
84. Martin A.B., Bricker J.T., Fishman M., et al. Neurologic complications of heart transplantation in children. J Heart Lung Transplant 11 5 (1992) 933-942
85. Adams D., Samuel D., Goulon-Goeau C., et al. The course and prognostic factors of familial amyloid polyneuropathy after liver transplantation. Brain 123 Pt 7 (2000) 1495-1504
86. Bolton C.F. Electrophysiologic changes in uremic neuropathy after successful renal transplantation. Neurology 26 2 (1976) 152-161
87. Fredericks S., Holt D.W., and MacPhee I.A. The pharmacogenetics of immunosuppression for organ transplantation: a route to individualization of drug administration. Am J Pharmacogenomics 3 5 (2003) 291-301
88. Mourad M., Wallemacq P., De Meyer M., et al. Biotransformation enzymes and drug transporters pharmacogenetics in relation to immunosuppressive drugs: impact on pharmacokinetics and clinical outcome. Transplantation 85 Suppl 7 (2008) S19-S24
89. Zivkovic S. Neuroimaging and neurologic complications after organ transplantation. J Neuroimaging 17 2 (2007) 110-123
90. Guarino M., Benito-Leon J., Decruyenaere J., et al. EFNS guidelines on management of neurological problems in liver transplantation. Eur J Neurol 13 1 (2006) 2-9
91. Palacios G., Druce J., Du L., et al. A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med 358 10 (2008) 991-998
92. Brenner R.P. The interpretation of the EEG in stupor and coma. Neurologist 11 5 (2005) 271-284
93. Rich M.M., Bird S.J., Raps E.C., et al. Direct muscle stimulation in acute quadriplegic myopathy. Muscle Nerve 20 6 (1997) 665-673
94. Berry G.T., Bridges N.D., Nathanson K.L., et al. Successful use of alternate waste nitrogen agents and hemodialysis in a patient with hyperammonemic coma after heart-lung transplantation. Arch Neurol 56 4 (1999) 481-484
95. Giraldo M., Martin D., Colangelo J., et al. Intestinal transplantation for patients with short gut syndrome and hypercoagulable states. Transplant Proc 32 6 (2000) 1223-1224
96. Chabolla D.R., and Wszolek Z.K. Pharmacologic management of seizures in organ transplant. Neurology 67 12 Suppl 4 (2006) S34-S38
97. Roos K.L. Central nervous system infections in solid organ, bone marrow, or stem cell transplant recipients. Continuum 10 2 (2004) 61-73