OKT3 neurotoxicity presenting as akinetic mutism

Transplantation

Volumn 75, Issue 7, 2003, Pages 1058-1060

  Pittock, Sean J ^a   Rabinstein, Alejandro A ^a   Edwards, Brooks S ^a   Wijdicks, Eelco F M ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYSTEINE ETHYL ESTER TC 99M; HYDROCORTISONE; OKT 3;

ADULT; AKINETIC MUTISM; APHASIA; ARTICLE; BLEPHAROSPASM; BRAIN DISEASE; BRAIN PERFUSION; CASE REPORT; CLINICAL FEATURE; DELIRIUM; DIAGNOSTIC IMAGING; DISEASE COURSE; DRUG WITHDRAWAL; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; LYMPHOCYTE COUNT; MALE; NEUROLOGIC EXAMINATION; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT OUTCOME;

EID: 0037446734     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000057830.67416.CE     Document Type: Article

References (10)

1. Vaughn A, Starnes VA, Oyer PE, et al. Prophylactic OKT3 used as induction therapy for heart transplantation. Circulation 1989; 80(5 pt 2): 11179-11183.
2. Thistlethwaite JR Jr, Stuart JK, Mayes JT, et al. Complications and monitoring of OKT3 therapy. Am J Kidney Dis 1988; 11(2): 112-119.
3. Agarwal RK, Ostaszeweski ML, Field LG, et al. Tumor necrosis factor and interleukin 6 in cerebrospinal fluid of a patient with recurrent adverse central nervous system events. Transplant Proc 1993; 25: 2143-2144.
4. Parizel PM, Snoeck HW, van den Hauwe L, et al. Cerebral complications of murine monoclonal CD3 antibody (OKT3): CT and MR findings. AJNR Am J Neuroradiol 1997; 18: 1935-1938.
5. Chatenoud L. Immunologic monitoring during OKT3 therapy. Clin Transplant 1993; 7(4 pt 2): 422-430.
6. Valldeoriola F, Graus F, Rimola A, et al. Cyclosporine-associated mutism in liver transplant patients. Neurology 1996; 46: 252-254.
7. Jeyarajah DR, Thistlethwaithe JR Jr. General aspects of cytokine-release syndrome: Timing and incidence of symptoms. Transplant Proc 1993; 25: 16-20.
8. Williams AF, Gagnon J. Neuron cell Thy-1 glycoprotein: Homology with immunoglobulin. Science 1982; 216: 696-703.
9. Birnbaum G. Studies on brain thymus cross reactive antigens. Brain Res 1975; 84: 111-121.
10. Quirce R, Carril J, Vallina N, et al. Effects of treatment with OKT3 on brain perfusion in a heart transplant patient with SPECT with 99mTc-HMPAO [in Spanish]. Rev Esp Med Nucl 1999; 18: 363-366.