Protective and therapeutic effect of triptolide in EAE explained by induction of major stress protein HSP70

Journal of Neuroimmunology

Volumn 217, Issue 1-2, 2009, Pages 10-11

  van Eden, Willem ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYTRIPTOLIDE; ALPHA CRYSTALLIN; CD4 ANTIGEN; GELDANAMYCIN; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; LLDT 8; PEPTIDE DERIVATIVE; TEPRENONE; TERPENOID DERIVATIVE; TRANSCRIPTION FACTOR FOXP3; TRIPTOLIDE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANTIINFLAMMATORY ACTIVITY; CD4+ CD25+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL TRIAL; DIABETES MELLITUS; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; EDITORIAL; HUMAN; IMMUNOMODULATION; MULTIPLE SCLEROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION; TRIPTERYGIUM; UVEORETINITIS;

ANIMALS; DITERPENES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; IMMUNOSUPPRESSIVE AGENTS; MICE; PHENANTHRENES;

EID: 70449628902     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2009.09.008     Document Type: Editorial

References (13)

1. Dello Russo C., Polak P.E., Mercado P.R., Spagnolo A., Sharp A., Murphy P., Kamal A., Burrows F.J., Fritz L.C., and Feinstein D.L. The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. J. Neurochem. 99 5 (2006) 1351-1362
2. Fu Y.F., Zhu Y.N., Ni J., Zhong X.G., Tang W., Zhou R., Zhou Y., Dong J.R., He P.L., Wan H., Li Y.C., Yang Y.F., and Zuo J.P. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation. J. Neuroimmunol. 175 (2006) 142-151
3. Kizelsztein P., Komarnytsky S., and Raskin I. Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex. J. Neuroimmunol. 217 (2009) 28-37 (this issue)
4. Kitamei H., Kitaichi N., Yoshida K., Nakai A., Fujimoto M., Kitamura M., Iwabuchi K., Miyazaki A., Namba K., Ohno S., and Onoe K. Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice. Immunobiology 212 (2007) 11-18
5. Ousman S.S., Tomooka B.H., van Noort J.M., Wawrousek E.F., O'Connor K.C., Hafler D.A., Sobel R.A., Robinson W.H., and Steinman L. Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature 448 (2007) 474-479
6. Prakken B.J., Samodal R., Le T.D., Giannoni F., Yung G.P., Scavulli J., Amox D., Roord S., de Kleer I., Bonnin D., Lanza P., Berry C., Massa M., Billetta R., and Albani S. Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 4228-4233
7. Quintana F.J., Farez M.F., Viglietta V., Iglesias A.H., Merbl Y., Izquierdo G., Lucas M., Basso A.S., Khoury S.J., Lucchinetti C.F., Cohen I.R., and Weiner H.L. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 18889-18894
8. Raz I., Elias D., Avron A., Tamir M., Metzger M., and Cohen I.R. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358 (2001) 1749-1753
9. van Eden W., van der Zee R., and Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat. Rev. Immunol. 5 (2005) 318-330
10. Wang Y., Mei Y., Feng D., and Xu L. Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. J. Neurosci. Res. 86 (2008) 2441-2449
11. Wieten L., Broere F., van der Zee R., Koerkamp E.K., Wagenaar J., and van Eden W. Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti-inflammatory immuno-modulators?. FEBS Lett. 581 (2007) 3716-3722
12. Wieten, L., van der Zee, R., Goedemans, R., Sijtsma, J., Serafini, M., Lubsen, N.H., van Eden, W., Broere, F., in press. Hsp70 expression and induction as a readout for detection of immune modulatory components in food. Cell Stress Chaperones. (Electronic publication ahead of print).
13. Zhang J.F., Huang R., Xu J., Jin S.J., and Yang Y.J. Protective effects of heat shock preconditioning on the experimental autoimmune encephalomyelitis rats. Zhongguo Dang Dai Er Ke Za Zhi 9 (2007) 563-566