Zicam-induced damage to mouse and human nasal tissue

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Lim, Jae H ^a   Davis, Greg E ^a   Wang, Zhenshan ^a   Li, Vicky ^a   Wu, Yuping ^a   Rue, Tessa C ^b   Storm, Daniel R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 3; ADRENALIN; BETA TUBULIN; GLUCONATE ZINC; LACTATE DEHYDROGENASE; LIDOCAINE; OLFACTORY MARKER PROTEIN; OXYMETAZOLINE; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; ZICAM; GLUCONIC ACID; TUBULIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; HISTOPATHOLOGY; HUMAN; MOUSE; NECROSIS; NONHUMAN; NOSE DISEASE; ODOR; OLFACTOMETRY; OLFACTORY DISCRIMINATION; OLFACTORY SYSTEM; PROTEIN EXPRESSION; SMELLING; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; INTRANASAL DRUG ADMINISTRATION; MALE; METABOLISM; NOSE MUCOSA; OLFACTORY RECEPTOR; PHYSIOLOGY; SMELLING DISORDER;

MUS;

ADMINISTRATION, INTRANASAL; ANIMALS; GLUCONATES; HUMANS; L-LACTATE DEHYDROGENASE; MALE; MICE; MICE, INBRED C57BL; NASAL MUCOSA; ODORS; OLFACTION DISORDERS; OLFACTORY RECEPTOR NEURONS; RECEPTORS, ODORANT; SMELL; TUBULIN;

EID: 70449575886     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007647     Document Type: Article

References (30)

1. Leopold DA, Bartels S (2002) Evaluation of olfaction. J Otolaryngol 31: Suppl 1: S18-23.
2. Holbrook EH, Leopold DA (2006) An updated review of clinical olfaction. Curr Opin Otolaryngol Head Neck Surg 14: 23-28.
3. Doty RL (2009) The olfactory system and its disorders. Semin Neurol 29: 74-81.
4. Jones LM, Fontanini A, Katz DB (2006) Gustatory processing: a dynamic systems approach. Curr Opin Neurobiol 16: 420-428.
5. Simon SA, de Araujo IE, Gutierrez R, Nicolelis MA (2006) The neural mechanisms of gustation: a distributed processing code. Nat Rev Neurosci 7: 890-901.
6. Angell M, Kassirer JP (1998) Alternative medicine-the risks of untested and unregulated remedies. N Engl J Med 339: 839-841.
7. Jafek BW, Linschoten MR, Murrow BW (2004) Anosmia after intranasal zinc gluconate use. Am J Rhinol 18: 137-141.
8. Alexander TH, Davidson TM (2006) Intranasal zinc and anosmia: the zinc-induced anosmia syndrome. Laryngoscope 116: 217-220.
9. Calof AL, Hagiwara N, Holcomb JD, Mumm JS, Shou J (2006) Neurogenesis and cell death in olfactory epithelium. J Neurobiol 30: 67-81.
10. Henion TR, Schwarting GA (2007) Patterning the developing and regenerating olfactory system. J Cell Physiol 210: 290-297.
11. Wong ST, Trinh K, Hacker B, Chan GC, Lowe G, et al. (2000) Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron 27: 487-497.
12. Slotnick B, Sanguino A, Husband S, Marquino G, Silberberg A (2007) Olfaction and olfactory epithelium in mice treated with zinc gluconate. Laryngoscope 117: 743-749.
13. Feron F, Perry C, McGrath JJ, Mackay-Sim A (1998) New techniques for biopsy and culture of human olfactory epithelial neurons. Arch Otolaryngol Head Neck Surg 124: 861-866.
14. Widdicombe JG (1986) The physiology of the nose. Clin Chest Med 7: 159-170.
15. Widdicombe J (1997) Microvascular anatomy of the nose. Allergy 52: 7-11.
16. Kim EY, Koh JY, Kim YH, Sohn S, Joe E, et al. (1999) Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures. Eur J Neurosci 11: 327-334.
17. Manev H, Kharlamov E, Uz T, Mason RP, Cagnoli CM (1997) Characterization of zinc-induced neuronal death in primary cultures of rat cerebellar granule cells. Exzp Neurol 146: 171-178.
18. Sheline CT, Behrens MM, Choi DW (2000) Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. J Neurosci 20: 3139-3146.
19. Chen CJ, Liao SL (2003) Zinc toxicity on neonatal cortical neurons: involvement of glutathione chelation. J Neurochem 85: 443-453.
20. Capasso M, Jeng JM, Malavolta M, Mocchegiani E, Sensi SL (2005) Zinc dyshomeostasis: a key modulator of neuronal injury. J Alzheimers Dis 8: 93-108.
21. Pavlica S, Gaunitz F, Gebhardt R (2009) Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells. Toxicol In Vitro 23: 653-659.
22. Matulionis DH (1975) Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regeneration. Am J Anat 142: 67-89.
23. 4 irrigation on behavior, biochemistry and morphology. Brain Res 140: 271-285.
24. Burd GD (1993) Morphological study of the effects of intranasal zinc sulfate irrigation on the mouse olfactory epithelium and olfactory bulb. Microsc Res Tech 24: 195-213.
25. McBride K, Slotnick B, Margolis FL (2003) Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study. Chem Senses 28: 659-670.
26. Eby GA, Halcomb WW (2006) Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common-cold treatment: a double-blind, placebo-controlled clinical trial. Altern Ther Health Med 12: 34-38.
27. Mossad SB (2003) Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. Qjm 96: 35-43.
28. Trinh K, Storm DR (2003) Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium. Nat Neurosci 6: 519-525.
29. Lund VJ, Mackay IS (1993) Staging in rhinosinusitus. Rhinology 31: 183-184.
30. Piccirillo JF, Merritt MG, Jr., Richards ML (2002) Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20). Otolaryngol Head Neck Surg 126: 41-47.