Sites of action for future therapy: An adenosine-dependent mechanism by which aspirin retains its antiinflammatory activity in cyclooxygenase-2 and NFκB knockout mice

Osteoarthritis and Cartilage

Volumn 7, Issue 4, 1999, Pages 361-363

  Cronstein, B N ^a   Montesinos, M C ^a   Weissmann, G ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aspirin; Cyclooxygenase; Inflammation

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE DEAMINASE; CARRAGEENAN; CYCLOOXYGENASE 2; DEXAMETHASONE; INDOMETACIN; METHOTREXATE; SALAZOSULFAPYRIDINE; SALICYLATE SODIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; CELL INFILTRATION; CHROMATOGRAPHY; CONFERENCE PAPER; CONTROLLED STUDY; KNOCKOUT MOUSE; MOUSE; NEUTROPHIL; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL;

EID: 0033166175     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1998.0236     Document Type: Conference Paper

References (6)

1. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971;231:232-5.
2. Weissmann G. NSAID's: Aspirin and aspirin-like drugs. In: Wyngaarden JB, Smith LH, Jr, Bennett JC, Eds. Cecil's Textbook of Medicine (19 Ed). Philadelphia, PA: W.B. Saunders Co 1992, pp. 114-118.
3. Abramson SB, Leszczynska-Piziak J, Clancy RM, Philips MR, Weissmann G. Inhibition of neutrophil function by aspirin-like drugs (NSAIDS): Requirement for assembly of heterotrimeric G proteins in bilayer phospholipid. Biochem Pharm 1994;47:563-72.
4. Kopp E, Ghosh S. Inhibition of NF-fappa B by sodium salicuylate and aspirin. Science 1994;265:956-9.
5. Cronstein BN, Van de Stouwe M, Druska L, Levin RI, Weissmann G. Nonsteroidal antiinflammatory agents inhibit stimulated neutrophil adhesion to endothelium: Adenosine dependent and independent mechanisms. Inflammation 1994; 18:323-35.
6. Cronstein BN, Weissmann G. Targets for antiinflammatory drugs. In: Annual Review of Pharmacology and Toxicology 1995;35:449-62.