Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women

Endocrine

Volumn 36, Issue 3, 2009, Pages 377-382

  Yan, Qun ^a   Hong, Jie ^a   Gu, Weiqiong ^a   Zhang, Yifei ^a   Liu, Qiaorui ^a   Su, Yuxia ^a   Zhang, Yuwen ^a   Li, Xiaoying ^a   Cui, Bin ^a   Ning, Guang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

FTO; Polycystic ovary syndrome; Single nucleotide polymorphism

Indexed keywords

ADOLESCENT; ADULT; ALLELE; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHINESE; CONTROL GROUP; CONTROLLED STUDY; FEMALE; FTO GENE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE DETECTION; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; YOUNG ADULT;

EID: 70449535442     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-009-9257-0     Document Type: Article

References (31)

1. MO Goodarzi R Azziz 2006 Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome Best Pract. Res. Clin. Endocrinol. Metab. 20 193 205 10.1016/j.beem.2006.02.005 1:CAS:528:DC%2BD28Xls1aqtbk%3D 16772151 (Pubitemid 43842923)
2. S Franks 2006 Diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria J. Clin. Endocr. Metab. 91 786 789 10.1210/jc.2005-2501 1:CAS:528:DC%2BD28Xis1Cmsbk%3D 16418209 (Pubitemid 43357737)
3. Y Shi M Guo J Yan, et al. 2007 Analysis of clinical characteristics in large-scale Chinese women with polycystic ovary syndrome Neuroendocrinol. Lett. 28 807 810 1:CAS:528:DC%2BD1cXht1eju7k%3D 18063948
4. TM Barber SJ Golding C Alvey, et al. 2008 Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome J. Clin. Endocrinol. Metab. 93 999 1004 10.1210/jc.2007-2117 1:CAS:528:DC%2BD1cXjsFymsrk%3D 18089693
5. A Gambineri C Pelusi V Vicennati, et al. 2002 Obesity and the polycystic ovary syndrome Int. J. Obes. Relat. Metab. Disord. 26 883 896 10.1038/sj.ijo.0801994 1:CAS:528:DC%2BD38XkslKms7o%3D 12080440 (Pubitemid 34756169)
6. K. Clement, T.I.A. Sorensen (eds.), Obesity: genomics and postgenomics (Infoma Healthcare, New York, 2007), pp. 19-58
7. S Franks 2006 Symposium: diet, nutrition and exercise in reproduction genetic and environmental origins of obesity relevant to reproduction Reprod. Biomed. Online 12 526 531 1:CAS:528:DC%2BD28Xltleisbs%3D 16790094
8. E Zeggini MN Weedon CM Lindgren, et al. 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 316 1336 1341 10.1126/science.1142364 1:CAS:528:DC%2BD2sXmtVymtb0%3D 17463249 (Pubitemid 46871654)
9. TM Frayling NJ Timpson MN Weedon, et al. 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 889 894 10.1126/science.1141634 1:CAS:528: DC%2BD2sXltVentL0%3D 17434869 (Pubitemid 46764279)
10. A Scuteri S Sanna WM Chen, et al. 2007 Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits PLoS Genet. 3 1 11 10.1371/journal.pgen.0030115 (Pubitemid 47203970)
11. SI Kring C Holst E Zimmermann, et al. 2008 FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness PLoS ONE 3 e2958 10.1371/journal.pone.0002958 18698412
12. C Dina D Meyre S Gallina, et al. 2007 Variation in FTO contributes to childhood obesity and severe adult obesity Nat. Genet. 39 724 727 10.1038/ng2048 1:CAS:528:DC%2BD2sXlvVSgtL0%3D 17496892 (Pubitemid 46848595)
13. DK Sanghera L Ortega S Han, et al. 2008 Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2, and FTO variants confer a significant risk BMC Med. Genet. 9 59 10.1186/1471-2350-9-59 18598350
14. K Hotta Y Nakata T Matsuo, et al. 2008 Variations in the FTO gene are associated with severe obesity in the Japanese J. Hum. Genet. 53 546 553 10.1007/s10038-008-0283-1 1:CAS:528:DC%2BD1cXmsVaqu7w%3D 18379722 (Pubitemid 351749344)
15. YC Chang PH Liu WJ Lee, et al. 2008 Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population Diabetes 57 2245 2252 10.2337/db08-0377 1:CAS:528: DC%2BD1cXps1Oisb8%3D 18487448
16. JT Tan R Dorajoo M Seielstad, et al. 2008 FTO variants are associated with obesity in the Chinese and Malay populations in Singapore Diabetes 57 2851 2857 10.2337/db08-0214 1:CAS:528:DC%2BD1MXhs1KntL8%3D 18599522
17. TM Barber AJ Bennett CJ Groves, et al. 2008 Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome Diabetologia 51 1153 1158 10.1007/s00125-008-1028-6 1:CAS:528: DC%2BD1cXmslWhu7k%3D 18478198
18. R Attaoua SA Mkadem S Raidan, et al. 2008 FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome Biochem. Biophys. Res. Commun. 373 230 234 10.1016/j.bbrc.2008.06.039 1:CAS:528: DC%2BD1cXotlajsr8%3D 18572014
19. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group 2004 Revised 2003 consensus on diagnostic criteria and long-term health risk related to polycystic ovary syndrome Fertil. Steril. 81 19 25
20. BF Zhou Cooperative Meta-Analysis Group of Working Group on Obesity in China 2002 Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults: study on optimal cut-off points of body mass index and waist circumference in Chinese adults Asia Pac. J. Clin. Nutr. 11 Suppl 8 S685 S693
21. Q Liu W Gu B Cui, et al. 2008 The association of TAAAAn repeat polymorphism in sex hormone-binding protein gene with polycystic ovary syndrome in Chinese population Endocrine 34 62 67 10.1007/s12020-008-9104-8 18937076
22. DR Matthews JP Hosker BA Naylor, et al. 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 412 419 10.1007/BF00280883 1:CAS:528:DyaL2MXlslKnu7k%3D 3899825 (Pubitemid 15018832)
23. X Chen D Yang Y Mo, et al. 2008 Prevalence of polycystic ovary syndrome in unselected women from southern China Eur. J. Obstet. Gynecol. Reprod. Biol. 139 59 64 10.1016/j.ejogrb.2007.12.018 18378061
24. H Li Y Wu RJ Loos, et al. 2008 Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population Diabetes 57 264 268 10.2337/db07-1130 1:CAS:528: DC%2BD1cXmt1ajsQ%3D%3D 17959933
25. M Horikoshi K Hara C Ito, et al. 2007 Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population Diabetologia 50 2461 2466 10.1007/s00125-007-0827-5 1:CAS:528:DC%2BD2sXht1Kku7nN 17928989 (Pubitemid 350060646)
26. S Omori Y Tanaka A Takahashi, et al. 2008 Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population Diabetes 57 791 795 10.2337/db07-0979 1:CAS:528: DC%2BD1cXjt1Chu74%3D 18162508
27. M Elia 2001 Obesity in the elderly Obes. Res. 9 S244 S248 10.1038/oby.2001.126
28. G Stratigopoulos S Padilla CA LeDuc, et al. 2008 Regulation of Fto/Ftm gene expression in mice and humans Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 R1185 R1196 1:CAS:528:DC%2BD1cXkvVyksLw%3D 18256137
29. R Fredriksson M Hagglund PK Olszewski, et al. 2008 The obesity gene, FTO, is of ancient origin, upregulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain Endocrinology 149 2062 2071 10.1210/en.2007-1457 1:CAS:528:DC%2BD1cXht1GmsLvN 18218688 (Pubitemid 351574484)
30. T Gerken CA Girard YC Tung, et al. 2007 The obesity associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase Science 318 1469 1472 10.1126/science.1151710 1:CAS:528:DC%2BD2sXhtlGmtLbI 17991826 (Pubitemid 350208961)
31. JE Cecil R Tavendale P Watt, et al. 2008 An obesity-associated FTO gene variant and increased energy intake in children N. Engl. J. Med. 359 2558 2566 10.1056/NEJMoa0803839 1:CAS:528:DC%2BD1cXhsV2ktrrF 19073975