The role of metabotropic glutamate receptor 5 in developmental lead neurotoxicity

Toxicology Letters

Volumn 191, Issue 2-3, 2009, Pages 223-230

  Xu, Jian ^a   Yan, Chong huai ^a   Yang, Bo ^b   Xie, Han fang ^a   Zou, Xiang yu ^a   Zhong, Le ^a   Gao, Yu ^a   Tian, Ying ^a   Shen, Xiao ming ^a  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI CHILDREN S MEDICAL CENTER   (China)

Author keywords

Developmental neurotoxicity; Hippocampus; Lead; Metabotropic glutamate receptor 5; Rat

Indexed keywords

LEAD ACETATE; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; LEAD POISONING; LONG TERM DEPRESSION; LONG TERM POTENTIATION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT;

ACTINS; ANIMALS; BLOTTING, WESTERN; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; IMMUNOENZYME TECHNIQUES; LACTATION; LEAD; LEAD POISONING, NERVOUS SYSTEM; NEURONS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

RATTUS;

EID: 70449527469     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.09.001     Document Type: Article

References (45)

1. Ayala J.E., Chen Y., Banko J.L., Sheffler D.J., Williams R., Telk A.N., Watson N.L., Xiang Z., Zhang Y., Jones P.J., Lindsley C.W., Olive M.F., and Conn P.J. mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology 34 (2009) 2057-2071
2. Balschun D., Zuschratter W., and Wetzel W. Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory. Neuroscience 142 (2006) 691-702
3. Balschun D., and Wetzel W. Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol. Biochem. Behav. 73 (2002) 375-380
4. Bellinger D.C., and Needleman H.L. Intellectual impairment and blood lead levels. N. Engl. J. Med. 349 (2003) 500-502
5. Braunewell K.H., Brackmann M., and Manahan-Vaughan D. Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?. Neuropharmacology 44 (2003) 707-715
6. Bressler J., Kim K.A., Chakraborti T., and Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem. Res. 24 (1999) 595-600
7. Bustin S.A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 25 (2000) 169-193
8. Canfield R.L., Henderson C.R., Cory-Slechta D.A., Cox C., Jusko T.A., and Lanphear B.P. Intellectual impairment in children with blood lead concentrations below 10 μg per deciliter. N. Engl. J. Med. 348 (2003) 1517-1526
9. Gasparini F., Lingenhöhl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., Biollaz M., Allgeier H., Heckendorn R., Urwyler S., Varney M.A., Johnson E.C., Hess S.D., Rao S.P., Sacaan A.I., Santori E.M., Veliçelebi G., and Kuhn R. 2-Methyl-6-(phenylethyl)-pyridine (MPEP), a potent, selective and systematically active mGluR5 receptor antagonist. Neuropharmacology 38 (1999) 1493-1503
10. Gilbert M.E., and Lasley S.M. Developmental lead (Pb) exposure reduces the ability of the NMDA antagonist MK-801 to suppress long-term potentiation (LTP) in the rat dentate gyrus in vivo. Neurotoxicol. Teratol. 29 (2007) 385-393
11. Grassi S., Frondarolim A., and Pettorossi V.E. Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei. J. Physiol. 543 (2002) 795-806
12. Guilarte T.R. Glutamatergic system and developmental lead neurotoxicity. Neurotoxicology 18 (1997) 665-672
13. Gutowski M., Altmann L., Sveinsson K., and Wiegand H. Synaptic plasticity in the CA1 and CA3 hippocampal region of pre- and postnatally lead-exposed rats. Toxicol. Lett. 95 (1998) 195-203
14. Harney S.C., Rowan M., and Anwyl R. Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering. J. Neurosci. 26 (2006) 1128-1132
15. Heidinger V., Manzerra P., and Wang X.Q. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J. Neurosci. 22 (2002) 5452-5461
16. Herrero I., Miras-Portugal M.T., and Sanchez-Prieto J. Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors. J. Biol. Chem. 273 (1998) 1951-1958
17. Hu H., Téllez-Rojo M.M., Bellinger D., Smith D., Ettinger A.S., Lamadrid-Figueroa H., Schwartz J., Schnaas L., Mercado-García A., and Hernández-Avila M. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environ. Health Perspect. 114 (2006) 1730-1735
18. Huang C.C., and Hsu K.S. Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of (S)-3,5-dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region. J. Neurochem. 96 (2006) 179-194
19. Huber K.M., Kayser M.S., and Bear M.F. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288 (2000) 1254-1257
20. Jia Z., Lu Y., Henderson J., Taverna F., Romano C., Abramow-Newerly W., Wojtowicz J.M., and Roder J. Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learn. Mem. 5 (1998) 331-343
21. Kemp A., and Manahan-Vaughan D. Hippocampal long-term depression: master or minion in declarative memory processes?. Trends Neurosci. 30 (2007) 111-118
22. Koros E., Rosenbrock H., Birk G., Weiss C., and Sams-Dodd F. The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats. Neuropsychopharmacology 32 (2007) 562-576
23. Lapointe V., Morin F., Ratte S., Croce A., Conquet F., and Lacaille J.C. Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition. J. Physiol. 555 (2004) 125-135
24. Lea IV P.M., and Faden A.I. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 12 (2006) 149-166
25. 2+-induced neuronal death in cultured hippocampal neurons. Toxicol. Appl. Pharmacol. 229 (2008) 351-361
26. Malenka R.C., and Bear M.F. LTP and LTD: an embarrassment of riches. Neuron 44 (2004) 5-21
27. Manahan-Vaughan D., Ngomba R.T., Storto M., Kulla A., Catania M.V., Chiechio S., Rampello L., Passarelli F., Capece A., Reymann K.G., and Nicoletti F. An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology 44 (2003) 17-25
28. Manahan-Vaughan D., and Braunewell K.H. The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. Cereb. Cortex 15 (2005) 1703-1713
29. Mannaioni G., Marino M.J., Valenti O., Traynelis S.F., and Conn P.J. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J. Neurosci. 21 (2001) 5925-5934
30. Naie K., and Manahan-Vaughan D. Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. Cereb. Cortex 14 (2004) 189-198
31. Neyman S., and Manahan-Vaughan D. Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro. Eur. J. Neurosci. 27 (2008) 1345-1352
32. Nihei M.K., Desmond N.L., McGlothan J.L., Kuhlmann A.C., and Guilarte T.R. N-Methyl-d-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning. Neuroscience 99 (2000) 233-242
33. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 (2001) e45
34. ©) for group wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30 (2002) e36
35. Peinnequin A., Mouret C., Birot O., Alonso A., Mathieu J., Clarencon D., Agay D., Chancerelle Y., and Multon E. Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green. BMC Immunol. 5 (2004) 3
36. Regunathan S., and Sundaresan R. Effects of organic and inorganic lead on synaptosomal uptake, release, and receptor binding of glutamate in young rats. J. Neurochem. 44 (1985) 1642-1646
37. Sarihi A., Jiang B., Komaki A., Sohya K., Yanagawa Y., and Tsumoto T. Metabotropic glutamate receptor type 5-dependent long-term potentiation of excitatory synapses on fast-spiking GABAergic neurons in mouse visual cortex. J. Neurosci. 28 (2008) 1224-1235
38. Savolainen K.M., Loikkanen J., and Naarala J. Amplification of glutamate-induced oxidative stress. Toxicol. Lett. 82-83 (1995) 399-405
39. Schnaas L., Rothenberg S.J., Flores M.F., Martinez S., Hernandez C., Osorio E., Velasco S.R., and Perroni E. Reduced intellectual development in children with prenatal lead exposure. Environ. Health Perspect. 114 (2006) 791-797
40. Tong S., von Schirnding Y.E., and Prapamontol T. Environmental lead exposure: a public health problem of global dimensions. Bull. World Health Organ. 78 (2000) 1068-1077
41. Topolnik L., Azzi M., Morin F., Kougioumoutzakis A., and Lacaille J.C. MGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones. J. Physiol. 575 (2006) 115-131
42. Toscano C.D., and Guilarte T.R. Lead neurotoxicity: from exposure to molecular effects. Brain Res. Brain Res. Rev. 49 (2005) 529-554
43. Wilson B.M., and Cox C.L. Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 2454-2459
44. Xu J., Zhu Y., Contractor A., and Heinemann S.F. mGluR5 has a critical role in inhibitory learning. J. Neurosci. 29 (2009) 3676-3684
45. Yuan J.S., Reed A., Chen Jr. F., and Stewart C.N. Statistical analysis of real-time PCR data. BMC Bioinform. 7 (2006) 85