Liver X receptor α regulates fatty acid synthase expression in chicken

Poultry Science

Volumn 88, Issue 12, 2009, Pages 2628-2635

  Demeure, O ^a,b,c   Duby, C ^a,b,c   Desert, C ^a,b,c   Assaf, S ^a,b,c   Hazard, D ^a,b,c   Guillou, H ^a   Lagarrigue, S ^a,b,c  

^a CEMAGREF   (France)

^b AGROCAMPUS OUEST   (France)

^c IFR 140   (France)

Author keywords

Chicken; Fatty acid synthase; Group H; Lipogenesis; Liver X receptor ; Member 3; Nuclear receptor subfamily 1

Indexed keywords

AVES; MAMMALIA; TRIFLUORO;

EID: 70449449726     PISSN: 00325791     EISSN: 15253171     Source Type: Journal    
DOI: 10.3382/ps.2009-00258     Document Type: Article

References (33)

1. Apfel, R., D. Benbrook, E. Lernhardt, M. A. Ortiz, G. Salbert, and M. Pfahl. 1994. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14:7025-7035.
2. Assaf, S., D. Hazard, F. Pitel, M. Morisson, M. Alizadeh, F. Gondret, C. Diot, A. Vignal, M. Douaire, and S. Lagarrigue. 2003. Cloning of cDNA encoding the nuclear form of chicken sterol response element binding protein-2 (SREBP-2), chromosomal localization, and tissue expression of chicken SREBP-1 and -2 genes. Poult. Sci. 82:54-61.
3. Caldwell, R. B., A. M. Kierzek, H. Arakawa, Y. Bezzubov, J. Zaim, P. Fiedler, S. Kutter, A. Blagodatski, D. Kostovska, M. Koter, J. Plachy, P. Carninci, Y. Hayashizaki, and J. M. Buerstedde. 2005. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Genome Biol. 6:R6.
4. Cha, J. Y., and J. J. Repa. 2007. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 282:743-751.
5. Chiang, J. Y., R. Kimmel, and D. Stroup. 2001. Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene 262:257-265.
6. Chisholm, J. W., J. Hong, S. A. Mills, and R. M. Lawn. 2003. The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J. Lipid Res. 44:2039-2048.
7. Chu, K., M. Miyazaki, W. C. Man, and J. M. Ntambi. 2006. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol. Cell. Biol. 26:6786-6798.
8. Denechaud, P. D., R. Dentin, J. Girard, and C. Postic. 2008. Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett. 582:68-73.
9. Desvergne, B., J. Michalik, and W. Wahli. 2006. Transcriptional regulation of metabolism. Physiol. Rev. 86:465-514.
10. Gill, S., R. Chow, and A. J. Brown. 2008. Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised. Prog. Lipid Res. 47:391-404.
11. Handschin, C., M. Podvinec, R. Looser, R. Amherd, and U. A. Meyer. 2001. Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Mol. Pharmacol. 60:681-689.
12. Hedges, S. B. 2002. The origin and evolution of model organisms. Nat. Rev. Genet. 3:838-849.
13. Hillier, L. W., W. Miller, E. Birney, W. Warren, R. C. Hardison, C. P. Ponting, P. Bork, D. W. Burt, M. A. Groenen, M. E. Delany, J. B. Dodgson, A. T. Chinwalla, P. F. Cliften, S. W. Clifton, K. D. Delehaunty, C. Fronick, R. S. Fulton, T. A. Graves, C. Kremitzki, D. Layman, V. Magrini, J. D. McPherson, T. L. Miner, P. Minx, W. E. Nash, M. N. Nhan, J. O. Nelson, L. G. Oddy, C. S. Pohl, J. Randall-Maher, S. M. Smith, J. W. Wallis, S. P. Yang, M. N. Romanov, C. M. Rondelli, B. Paton, J. Smith, D. Morrice, L. Daniels, H. G. Tempest, L. Robertson, J. S. Masabanda, D. K. Griffin, A. Vignal, V. Fillon, L. Jacobbson, S. Kerje, L. Andersson, R. P. Crooijmans, J. Aerts, J. J. van der Poel, H. Ellegren, R. B. Caldwell, S. J. Hubbard, D. V. Grafham, A. M. Kierzek, S. R. McLaren, I. M. Overton, H. Arakawa, K. J. Beattie, Y. Bezzubov, P.E. Boardman, J. K. Bonfield, M. D. Croning, R. M. Davies, M. D. Francis, S. J. Humphray, C. E. Scott, R. G. Taylor, C. Tickle, W. R. Brown, J. Rogers, J. M. Buerstedde, S. A. Wilson, L. Stubbs, I. Ovcharenko, L. Gordon, S. Lucas, M. M. Miller, H. Inoko, T. Shiina, J. Kaufman, J. Salomonsen, K. Skjoedt, G. K. Wong, J. Wang, B. Liu, J. Yu, H. Yang, M. Nefedov, M. Koriabine, P. J. Dejong, L. Goodstadt, et al. 2004. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432:695-716.
14. Janowski, B. A., P. J. Willy, T. R. Devi, J. R. Falck, and D. J. Mangelsdorf. 1996. An oxysterol signalling pathway mediated by the nuclear receptor LXR α. Nature 383:728-731.
15. Joseph, S. B., B. A. Laffitte, P. H. Patel, M. A. Watson, K. E. Matsukuma, R. Walczak, J. L. Collins, T. F. Osborne, and P. Tontonoz. 2002. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J. Biol. Chem. 277:11019-11025.
16. Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488-492.
17. Kuriyama, H., G. Liang, L. J. Engelking, J. D. Horton, J. L. Goldstein, and M. S. Brown. 2005. Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cell Metab. 1:41-51.
18. Lagarrigue, S., S. Daval, A. Bordas, and M. Douaire. 2000. Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption. Genet. Sel. Evol. 32:205-216.
19. Lehmann, J. M., S. A. Kliewer, L. B. Moore, T. A. Smith-Oliver, B. B. Oliver, J. L. Su, S. S. Sundseth, D. A. Winegar, D. E. Blanchard, T. A. Spencer, and T. M. Willson. 1997. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272:3137-3140.
20. Lu, T. T., J. J. Repa, and D. J. Mangelsdorf. 2001. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J. Biol. Chem. 276:37735-37738.
21. Mouse Genome Sequencing Consortium. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature 420:520-562.
22. O'Hea, E. K., and G. A. Leveille. 1969. Lipid biosynthesis and transport in the domestic chick (Gallus domesticus). Comp. Biochem. Physiol. 30:149-159.
23. Pawar, A., D. Botolin, D. J. Mangelsdorf, and D. B. Jump. 2003. The role of liver X receptor-α in the fatty acid regulation of hepatic gene expression. J. Biol. Chem. 278:40736-40743.
24. Peet, D. J., B. A. Janowski, and D. J. Mangelsdorf. 1998. The LXRs: A new class of oxysterol receptors. Curr. Opin. Genet. Dev. 8:571-575.
25. Repa, J. J., G. Liang, J. Ou, Y. Bashmakov, J. M. Lobaccaro, I. Shimomura, B. Shan, M. S. Brown, J. L. Goldstein, and D. J. Mangelsdorf. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev. 14:2819-2830.
26. Shinar, D. M., N. Endo, S. J. Rutledge, R. Vogel, G. A. Rodan, and A. Schmidt. 1994. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene 147:273-276.
27. Song, C., R. A. Hiipakka, J. M. Kokontis, and S. Liao. 1995. Ubiquitous receptor: Structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones. Ann. N. Y. Acad. Sci. 761:38-49.
28. Talukdar, S., and F. B. Hillgartner. 2006. The mechanism mediating the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist TO-901317. J. Lipid Res. 47:2451-2461.
29. Teboul, M., E. Enmark, Q. Li, A. C. Wikstrom, M. Pelto-Huikko, and J. A. Gustafsson. 1995. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc. Natl. Acad. Sci. USA 92:2096-2100.
30. Tontonoz, P., J. B. Kim, R. A. Graves, and B. M. Spiegelman. 1993. ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13:4753-4759.
31. Willy, P. J., K. Umesono, E. S. Ong, R. M. Evans, R. A. Heyman, and D. J. Mangelsdorf. 1995. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9:1033-1045.
32. Yanai, I., H. Benjamin, M. Shmoish, V. Chalifa-Caspi, M. Shklar, R. Ophir, A. Bar-Even, S. Horn-Saban, M. Safran, E. Domany, D. Lancet, and O. Shmueli. 2005. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics 21:650-659.
33. Yokoyama, C., X. Wang, M. R. Briggs, A. Admon, J. Wu, X. Hua, J. L. Goldstein, and M. S. Brown. 1993. SREBP-1, a basic-helixloop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75:187-197.