Intraneuronal signaling pathways of metallothionein

Journal of Neuroscience Research

Volumn 87, Issue 13, 2009, Pages 2926-2936

  Asmussen, Johanne Wirenfeldt ^a   Von Sperling, Marie Louise ^a   Penkowa, Milena ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Metallothionein; Molecular mechanisms; Neurite outgrowth; Primary neurons; Signal transduction

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE SERINE KINASE 3ALPHA; GUANINE NUCLEOTIDE BINDING PROTEIN; METALLOTHIONEIN II; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GRANULE CELL; IN VITRO STUDY; NERVE CELL CULTURE; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CEREBELLUM; DRUG EVALUATION, PRECLINICAL; HETEROTRIMERIC GTP-BINDING PROTEINS; METALLOTHIONEIN; NERVE TISSUE PROTEINS; NEURITES; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-JUN; RABBITS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TYPE C PHOSPHOLIPASES;

EID: 70449348627     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22118     Document Type: Article

References (38)

1. Ambjorn M, Asmussen JW, Lindstam M, Gotfryd K, Jacobsen C, Kiselyov VV, Moestrup SK, Penkowa M, Bock E, Berezin V. 2008. Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family. J Neurochem 104: 21-37. (Pubitemid 350265072)
2. Bardwell L. 2006. Mechanisms of MAPK signalling specificity. Biochem Soc Trans 34:837-841.
3. Bhat RV, Budd Haeberlein SL, Avila J. 2004. Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 89:1313-1317. (Pubitemid 38802652)
4. Bremner I, Morrison JN, Wood AM, Arthur JR. 1987. Effects of changes in dietary zinc, copper and selenium supply and of endotoxin administration on metallothionein I concentrations in blood cells and urine in the rat. J Nutr 117:1595-1602. (Pubitemid 18021175)
5. Brunet A, Datta SR, Greenberg ME. 2001. Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 11:297-305. (Pubitemid 32524094)
6. Chung RS, West AK. 2004. A role for extracellular metallothioneins in CNS injury and repair. Neuroscience 123:595-599. (Pubitemid 38045398)
7. Chung RS, Vickers JC, Chuah MI, West AK. 2003. Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury. J Neurosci 23:3336-3342.
8. Chung RS, Hidalgo J, West AK. 2008a. New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration. J Neurochem 104:14-20. (Pubitemid 350265070)
9. Chung RS, Penkowa M, Dittmann J, King CE, Bartlett C, Asmussen JW, Hidalgo J, Carrasco J, Leung YK, Walker AK, Fung SJ, Dunlop SA, Fitzgerald M, Beazley LD, Chuah MI, Vickers JC, West AK. 2008b. .Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J Biol Chem 283:15349-15358.
10. Coyle P, Philcox JC, Carey LC, Rofe AM. 2002. Metallothionein: the multipurpose protein. Cell Mol Life Sci 59:627-647.
11. Desrivieres S, Kunz C, Barash I, Vafaizadeh V, Borghouts C, Groner B. 2006. The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition. J Mammary Gland Biol Neoplasia 11:75-87. (Pubitemid 44309191)
12. Eswarakumar VP, Lax I, Schlessinger J. 2005. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 16:139-149. (Pubitemid 40616112)
13. Feldman EL, Sullivan KA, Kim B, Russell JW. 1997. Insulin-like growth factors regulate neuronal differentiation and survival. Neurobiol Dis 4: 201-214. (Pubitemid 27465510)
14. Fielding CA, McLoughlin RM, McLeod L, Colmont CS, Najdovska M, Grail D, Ernst M, Jones SA, Topley N, Jenkins BJ. 2008. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. J Immunol 181:2189-2195.
15. Giralt M, Penkowa M, Lago N, Molinero A, Hidalgo J. 2002. Metallothionein- 1 + 2 protect the CNS after a focal brain injury. Exp Neurol 173:114-128. (Pubitemid 34081731)
16. Hidalgo J, Giralt M, Garvey JS, Armario A. 1988. Physiological role of glucocorticoids on rat serum and liver metallothionein in basal and stress conditions. Am J Physiol 254:E71-E78. (Pubitemid 18054430)
17. Hidalgo J, Aschner M, Zatta P, Vasak M. 2001. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull 55:133-145. (Pubitemid 32722153)
18. Hidalgo J, Penkowa M, Espejo C, Martinez-Caceres EM, Carrasco J, Quintana A, Molinero A, Florit S, Giralt M, Ortega-Aznar A. 2006. Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation. Exp Biol Med 231:1450-1458. (Pubitemid 44547836)
19. Hooper C, Killick R, Lovestone S. 2008. The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104:1433-1439.
20. Jochum W, Passegue E, Wagner EF. 2001. AP-1 in mouse development and tumorigenesis. Oncogene 20:2401-2412.
21. Jope RS, Yuskaitis CJ, Beurel E. 2006. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 32: 577-595.
22. Klassen RB, Crenshaw K, Kozyraki R, Verroust PJ, Tio L, Atrian S, Allen PL, Hammond TG. 2004. Megalin mediates renal uptake of heavy metal metallothionein complexes. Am J Physiol Renal Physiol 287:F393-F403. (Pubitemid 39095952)
23. Kohler LB, Berezin V, Bock E, Penkowa M. 2003. The role of metallothionein II in neuronal differentiation and survival. Brain Res 992:128-136. (Pubitemid 37357003)
24. Kolkova K, Novitskaya V, Pedersen N, Berezin V, Bock E. 2000. Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. J Neurosci 20:2238-2246. (Pubitemid 30230077)
25. Li Y, Cam J, Bu G. 2001. Low-density lipoprotein receptor family: endocytosis and signal transduction. Mol Neurobiol 23:53-67. (Pubitemid 32948272)
26. Marinissen MJ, Gutkind JS. 2001. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 22:368-376. (Pubitemid 32592476)
27. Nelson TJ, Sun MK, Hongpaisan J, Alkon DL. 2008. Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair. Eur J Pharmacol 585:76-87.
28. Penkowa M. 2006. Metallothioneins are multipurpose neuroprotectants during brain pathology. FEBS J 273:1857-1870.
29. Penkowa M, Carrasco J, Giralt M, Moos T, Hidalgo J. 1999. CNS wound healing is severely depressed in metallothionein I- and II-deficient mice. J Neurosci 19:2535-2545. (Pubitemid 29162402)
30. Repici M, Borsello T. 2006. JNK pathway as therapeutic target to prevent degeneration in the central nervous system. Adv Exp Med Biol 588:145-155.
31. Ronn LC, Ralets I, Hartz BP, Bech M, Berezin A, Berezin V, Moller A, Bock E. 2000. A simple procedure for quantification of neurite outgrowth based on stereological principles. J Neurosci Methods 100:25-32. (Pubitemid 30782298)
32. Schousboe A, Meier E, Drejer J, Hertz L. 1989. Preparation of primary cultures of mouse (rat) cerebellar granule cells in a dissection and tissue culture manual for the nervous system. New York: Alan R. Liss. p 203-206.
33. Silva AJ, Kogan JH, Frankland PW, Kida S. 1998. CREB and memory. Annu Rev Neurosci 21:127-148.
34. Wayman GA, Lee YS, Tokumitsu H, Silva A, Soderling TR. 2008. Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron 59:914-931.
35. West AK, Chuah MI, Vickers JC, Chung RS. 2004. Protective role of metallothioneins in the injured mammalian brain. Rev Neurosci 15: 157-166. (Pubitemid 39050279)
36. Wolff NA, Abouhamed M, Verroust PJ, Thevenod F. 2006. Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells. J Pharmacol Exp Ther 318:782-791. (Pubitemid 44061252)
37. Yu CW, Chen JH, Lin LY. 1997. Metal-induced metallothionein gene expression can be inactivated by protein kinase C inhibitor. FEBS Lett 420:69-73. (Pubitemid 28037202)
38. Yu H, Kortylewski M, Pardoll D. 2007. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7:41-51. (Pubitemid 46020826)