Development of a two-dimensional liquid chromatography system for isolation of drug metabolites

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 3, 2010, Pages 649-657

  Jayamanne, Mala ^a   Granelli, Ingrid ^a   Tjernberg, Agneta ^b   Edlund, Per Olof ^b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b Biovitrum AB ^*  (Sweden)

Author keywords

Drug metabolism; Mass spectrometry; Pentaflurophenylpropyl column; Porphine; Two dimensional liquid chromatography

Indexed keywords

1 [3 [2 [(2 ETHOXY 3 PYRIDINYL)OXY]ETHOXY] 2 PYRAZINYL] 2 METHYLPIPERAZINE; AMIDE; AMPEROZIDE; BVT 2938; DRUG METABOLITE; HYDROGEN PEROXIDE; PENTAFLUOROPHENYLPROPYL; PIPERAZINE DERIVATIVE; PROPANE; TETRAKIS(4 SULFOPHENYL)PORPHINE; TOLTERODINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG STRUCTURE; IN VITRO STUDY; ISOLATION PROCEDURE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; ONLINE SYSTEM; OXIDATION; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TWO DIMENSIONAL LIQUID CHROMATOGRAPHY;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; RATS;

EID: 70449122138     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.09.007     Document Type: Article

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