Identification of BVT.2938 metabolites by LC/MS and LC/MS/MS after in vitro incubations with liver microsomes and hepatocytes

Journal of Pharmaceutical and Biomedical Analysis

Volumn 34, Issue 5, 2004, Pages 1079-1090

  Edlund, Per Olof ^a   Baranczewski, Pawel ^a  

^a Preclinical R and D   (Sweden)

Author keywords

Accurate mass; Chemiluminescent nitrogen detector; Deuterium exchange; Drug metabolism; Ipso Substitution; Nitrogen specific detection; O 18 labelling

Indexed keywords

1 [3 [2 [(2 ETHOXY 3 PYRIDINYL)OXY]ETHOXY] 2 PYRAZINYL] 2 METHYLPIPERAZINE; ANTIDIABETIC AGENT; BICARBONATE; BUFFER; BVT 2938; CYTOCHROME P450; DEUTERIUM; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE; NITROGEN; PIPERAZINE DERIVATIVE; SEROTONIN 2C AGONIST; SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMOLUMINESCENCE; CORRELATION ANALYSIS; CRYOPRESERVATION; DEALKYLATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MALE; MONKEY; NITROGEN DETECTOR; NONHUMAN; PRIORITY JOURNAL; RADIATION DETECTION; RAT; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; HEPATOCYTES; HUMANS; MACACA FASCICULARIS; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS;

EID: 1542362309     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2003.12.010     Document Type: Article

References (17)

1. Edlund P.O. J. Mass Spectrom. 30:1995;1380-1392.
2. Liu D.Q., Hop C.E.C.A., Beconi M.G., Mao A., Lee Chiu S.A. Rapid Commun. Mass Spectrom. 15:2001;1832-1839.
3. Ohashi N., Furuuchi S., Yoshikawa M. J. Pharm. Biomed. Anal. 18:1998;325-334.
4. Taylor E.W., Qian M.G., Dollinger G.D. Anal. Chem. 74:2002;3232-3238.
5. Taylor E.W., Jia W., Bush M., Dollinger G.D. Anal. Chem. 70:1998;3339-3347.
6. Hopfgartner G., Vilbois F. Analusis. 28:2000;906-914.
7. Kwok D.W.K., Pillay G., Vaughan R., Axelson J.E., McErlane K.M. J. Pharm. Sci. 79:1990;857-861.
8. Brown S.Y., Garland W.A., Fukuda E.K. Drug. Metabol. Dispos. 18:1990;546-547.
9. Dow J., Piriou F., wolf E., Dulery B.D., Haegle K.D. Drug. Metabol. Dispos. 22:1994;738-749.
10. Schaefer W.H. Drug. Metabol. Dispos. 20:1992;130-133.
11. Tremaine L.M., Stroh J.G., Ronfeld R.A. Drug. Metabol. Dispos. 17:1989;58-63.
12. Fisher M.B., Campanale K., Ackermann B.L., Van den Branden M., Wrighton S.A. Drug Metabol. Dispos. 28:2000;560-566.
13. Luffer-Atlas D., Vincent S.H., Painter S.K., Arison B.H., Stearns R.H., Lee Chiu S.H. Drug Metabol. Dispos. 25:1997;940-952.
14. Rodriguez R.J., Proteau P.J., Marquez B.L., Hetherington C.L., Buckholz C.L., O'Connel K.L. Drug Metabol. Dispos. 27:1999;880-886.
15. B. Testa, Biochemistry of Redox Reactions, Academic Press, London, 1995, pp. 236-240.
16. Ohe T., Mashino T., Hirobe M. Arch. Biochem. Biophys. 310:1994;402-409.
17. Ohe T., Mashino T., Hirobe M. Tetrahedron Lett. 42:1995;7681-7684.